Roles for neural crest derivatives in retaining motor neuron cell bodies in the fish embryonic spinal cord.
| Project/Area Number |
23570245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tohoku University |
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Principal Investigator |
SATO-MAEDA Mika 東北大学, 理学(系)研究科(研究院), 教育研究支援者 (40292205)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経冠細胞 / 運動神経 / グリア細胞 / Tag1 / 細胞間相互作用 / Schwann細胞 / TAG-1 / 細胞分化 |
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| Research Abstract |
We showed Tag1-expressing neural crest cells (NCCs) play an important role to prevent motor neuron emigration from the embryonic spinal cord in Zebrafish. Tag1 deficiency causes disruption of NCC alignment along axon, cell death of NCC, and Schwann cell reduction. Such embryos show the dislocation of motor neuron cell body out of the spinal cord. The results show that the Tag1-mediated interaction between NCC and motor axon is required for the differentiation of functional Schwann cells, and that comparable function of NCC derivatives to retain the integrity of embryonic spinal cord is conserved among vertebrates.
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Report
(4 results)
Research Products
(11 results)
