Comprehensive analysis on Hox and ParaHox genes in the primitive deuterostomes

• Project/Area Number: 23570266
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Japan Agency for Marine-Earth Science and Technology (2012-2015); 沖縄科学技術大学院大学 (2011)
• Principal Investigator: IKUTA Tetsuro 国立研究開発法人海洋研究開発機構, 海洋生物多様性研究分野, 技術研究員 (80584846)
• Project Period (FY): 2011-04-28 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: Hox/ParaHox / 新口動物 / 進化 / 半索動物 / 棘皮動物 / ゲノム / 転写因子 / BAC / 次世代シークエンサー / 遺伝子発現解析 / 発生 / 国際情報交流：米国、イタリア、台湾 / 国際情報交流:米国、イタ リア、台湾 / WISH法

Outline of Final Research Achievements

Hox and ParaHox genes have been regarded to play a central role in anterior-posterior patterning of the animal body and its evolution. In this study, cluster organizations and developmental expression patterns of Hox and ParaHox genes in the primitive deuterostomes, the hemichordate acorn worm and the crinoid feather star were analyzed. The results suggested that these animals retain the fundamental developmental programs to gain insights into the origins of deuterostome and chordate body plans.

Research Products

• [Journal Article] Identification of an intact ParaHox cluster with temporal colinearity but altered spatial colinearity in the hemichordate Ptychodera flava (2013)
  • Author(s): Ikuta, T. Chen, Y. C. Annunziata, R. Ting, H. C. Tung, C. H. Koyanagi, R. Tagawa, K. Humphreys, T. Fujiyama, A. Saiga, H. Satoh, N. Yu, J. K. Arnone, M. I. Su, Y. H.
  • Journal Title: BMC Evolutionary Biology Volume: 13 Issue: 1 Pages: 129-129
  • DOI: 10.1186/1471-2148-13-129
  • Peer Reviewed
• [Journal Article] Identical genomic organization of two hemichordate hox clusters. (2012)
  • Author(s): Freeman R, Ikuta T, Wu M, Koyanagi R, Kawashima T, Tagawa K, Humphreys T, Fang GC, Fujiyama A, Saiga H, Lowe C, Worley K, Jenkins J, Schmutz J, Kirschner M, Rokhsar D, Satoh N, Gerhart J.
  • Journal Title: Current Biology Volume: 22 Issue: 21 Pages: 2053-2058
  • DOI: 10.1016/j.cub.2012.08.052
  • Peer Reviewed
• [Presentation] ニッポンウミシダParaHox遺伝子群のクラスター構造と発現 (2016)
  • Author(s): 生田 哲朗、大森 紹仁、津田 美和子、高木 善弘、近藤 真理子
  • Organizer: 第68回日本動物学会関東支部大会
  • Place of Presentation: 神奈川大学横浜キャンパス（神奈川県横浜市）
  • Year and Date: 2016-03-12