The elucidation of oxidation mechanism of a DNA base and search of the highly bioavailable antioxidants
| Project/Area Number |
23580167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kibi International University (2013)
Kobe University (2011-2012) |
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Principal Investigator |
KANAZAWA Kazuki 吉備国際大学, 地域創成農学部, 教授 (90031228)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ８－オキソグアノシン / DNA塩基の酸化 / 脂質ヒドロペルオキシド / 抗酸化物質 / ケルセチン / ルテオリン / ビタミンE / ビタミンC / 8-オキソグアノシン / 抗酸化成分 / 8ーオキソグアノシン / 脂質ヒドロぺルオキシド / 塩基酸化 / 抗酸化剤 / OHラジカル / DNA変異 / グアノシンの酸化 / 過酸化水素 |
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| Research Abstract |
The oxidative formation of 8-oxo-guanosine in DNA is closely associated with the induction of degenerative diseases, including cancer. However, its endogenous oxidant is unclear. The present study showed that the endogenous oxidant was lipid hydroperoxides generating in biomembrane such as mitochondrial membrane, but was not hydrogen peroxide that had been recognized conventionally. Also, the study found that lipid-soluble antioxidants were able to suppress the formation of 8-oxo-guanosine. Thus, vegetables, fruits and tea including the lipid-soluble antioxidants such as xanthophyll astaxanthin and catechol flavonoids, quercetin and liteorin, can prevent form degenerative diseases.
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Report
(4 results)
Research Products
(30 results)
