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Nonalcoholic steatohepatitis induced by the excess ingestion of fructose and its prevention by functional foods ingredient

Research Project

Project/Area Number 23580181
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionOsaka Prefecture University

Principal Investigator

INUI Hiroshi  大阪府立大学, 総合リハビリテーション学部, 教授 (20193568)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsスクロース / フルクトース / 腸管吸収 / 腸内細菌叢 / 脂肪性肝炎 / 肥満 / 機能性食品成分 / NASH / 食品機能性 / 脂肪肝
Research Abstract

When KK-Ay mice were fed a high-sucrose or high-fructose diet, the growth of Bifidobacterium in cecum was suppressed. The change in microflora may associate with the pathology of nonalcoholic steatohepatitis induced by the excess ingestion of fructose, as well as the case of the ingestion of high-fat diets.
From eucalyptus extract, tellimagrandin I, a kind of ellagitannins, was isolated as an inhibitor for intestinal fructose absoption. In addition to eucalyptus extract, banaba, guava and olive extracts also inhibited intestinal fructose absorption and suppressed adiposity induced by the excess ingestion of fructose in rats.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012 Other

All Journal Article (4 results) Presentation (2 results) Book (2 results)

  • [Journal Article] フルクトースによるグリケーションが健康・美容に与える影響とその予防(ユーカリ葉ポリフェノール)2014

    • Author(s)
      杉本圭一郎、乾博、山内俊一
    • Journal Title

      フレグランスジャーナル

      Volume: 42 Pages: 25-32

    • Related Report
      2013 Final Research Report
  • [Journal Article] フルクトースによるグリケーションが健康・美容に与える影響とその予防(ユーカリ葉ポリフェノール)2014

    • Author(s)
      杉本圭一郎、乾博、山内俊一
    • Journal Title

      フレグランスジャーナル

      Volume: 42 Pages: 25-32

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Hydrolyzable tannins in the leaf extract of Eucalyptus globulus suppress fructose absorption in the Caco-2 cell line2013

    • Author(s)
      Sugimoto K, Yoshizawa K, Amako M, Yoshimura M, Amakura Y, Harada N, Yamaji R, Fujita T, Nakagawa K, Hayashi S and Inui H.
    • Journal Title

      Anal. Nutr. Metab

      Volume: 63 Pages: 1628-1629

    • Related Report
      2013 Final Research Report
  • [Journal Article] Hydrolyzable tannins in the leaf extract of Eucalyptus globules suppress fructose absorption in the Caco-2 cell line2013

    • Author(s)
      Sugimoto K, Kanako Y, Amako M, Yoshimura M, Amakura Y, Harada N, Yamaji R, Fujita T, Nakagawa K, Harashi S, Inui H
    • Journal Title

      Annals of Nutrition and Metabolism

      Volume: 63 Pages: 1628-1629

    • Related Report
      2013 Annual Research Report
  • [Presentation] 高スクロース食摂取KK-Ayマウスの腸内細菌叢と肝臓障害2013

    • Author(s)
      尾崎桃子、杉本圭一郎、中川一弥、副島友莉恵、熊谷有紗、高橋芳久、福里利夫、山内俊一、庄條愛子、原田直樹、中野長久、乾博、山地亮一
    • Organizer
      2013年度日本農芸化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 高スクロース食摂取KK-Ayマウスの腸内細菌叢と肝臓障害

    • Author(s)
      尾崎桃子、杉本圭一郎、中川一弥、副島友莉恵、熊谷有紗、高橋芳久、福里利夫、山内俊一、庄條愛子、原田直樹、中野長久、乾博、山地亮一
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Book] Royal Socienty of Chemistry2012

    • Author(s)
      Sugimoto K, Inui, H and Yamanouchi T.
    • Publisher
      Assays of fructose in experimental nutrition; in Dietary Sugars : Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus); Preedy, V. R. Ed.
    • Related Report
      2013 Final Research Report
  • [Book] Assays of fructose in experimental nutrition; in Dietary Sugars: Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus) (V. R. Preedy ed.)2012

    • Author(s)
      K. Sugimoto, H. Inui and T. Yamanouchi
    • Total Pages
      19
    • Publisher
      RSC Publishing
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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