Nonalcoholic steatohepatitis induced by the excess ingestion of fructose and its prevention by functional foods ingredient
Project/Area Number |
23580181
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
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Research Institution | Osaka Prefecture University |
Principal Investigator |
INUI Hiroshi 大阪府立大学, 総合リハビリテーション学部, 教授 (20193568)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | スクロース / フルクトース / 腸管吸収 / 腸内細菌叢 / 脂肪性肝炎 / 肥満 / 機能性食品成分 / NASH / 食品機能性 / 脂肪肝 |
Research Abstract |
When KK-Ay mice were fed a high-sucrose or high-fructose diet, the growth of Bifidobacterium in cecum was suppressed. The change in microflora may associate with the pathology of nonalcoholic steatohepatitis induced by the excess ingestion of fructose, as well as the case of the ingestion of high-fat diets. From eucalyptus extract, tellimagrandin I, a kind of ellagitannins, was isolated as an inhibitor for intestinal fructose absoption. In addition to eucalyptus extract, banaba, guava and olive extracts also inhibited intestinal fructose absorption and suppressed adiposity induced by the excess ingestion of fructose in rats.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Hydrolyzable tannins in the leaf extract of Eucalyptus globules suppress fructose absorption in the Caco-2 cell line2013
Author(s)
Sugimoto K, Kanako Y, Amako M, Yoshimura M, Amakura Y, Harada N, Yamaji R, Fujita T, Nakagawa K, Harashi S, Inui H
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Journal Title
Annals of Nutrition and Metabolism
Volume: 63
Pages: 1628-1629
Related Report
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[Book] Royal Socienty of Chemistry2012
Author(s)
Sugimoto K, Inui, H and Yamanouchi T.
Publisher
Assays of fructose in experimental nutrition; in Dietary Sugars : Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus); Preedy, V. R. Ed.
Related Report
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