| Project/Area Number |
23590031
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
KAWASAKI Ikuo 武庫川女子大学, 薬学部, 教授 (00234055)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIDE Kiyoharu 武庫川女子大学, 薬学部, 教授 (10237711)
YAMASHITA Yamashita 京都薬科大学, 薬学部, 教授 (20239982)
UCHIMOTO Hitomi 武庫川女子大学, 薬学部, 助手 (23590031)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 複素環 / イオン化合物 / キラルリガンド / 不斉合成 / 環境調和型 / 複素環化合物 / 有機合成反応 / リサイクル / 触媒的不斉水素移動型還元反応 / 有機合成 / 高効率的 |
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| Research Abstract |
Various novel chiral ionic ligands which has the structure of the quaternary ammonium salt in the nitrogen containing heterocycle were prepared. There catalytic ability was evaluated by asymmetric reduction of prochiral ketones in the catalytic asymmetric transfer hydrogenation (CATH) by using chiral ionic ligands, Ru and formic acid as a hydrogen source and ionic liquid as a reaction medium. Furthermore, this reaction system of CATH could be expanded to recycling CATH (RCATH). From these results, I could achieve the development of the environmental friendly and highly efficient organic synthesis using characteristics of the heterocycle. And this method could be applied to the asymmetric synthesis of pharmaceutical useful compound.
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