| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Research Abstract |
The controls of solution-mediated polymorphic transition and crystal growth rate of drugs were conducted, utilizing inclusion complexations with cyclodextrins (CyDs). 1. A new polymorph of acetohexamide (Form VI) was prepared via the formation of a complex with 2-hydroxybutyl-b-cyclodextrin (HB-b-CyD) in aqueous solution. The new crystalline Form VI was highly soluble in water and physically and chemically stable, compared with other polymorphs (Forms I~V). 2. The crystal shape of aspirin was changed from plate to needle crystals, when the crystallizing solvent was changed from water to aqueous 2,6-dimethyl-b-CyD and 2-hydroxybutyl-b-CyD solutions. The results indicate that 2-hydroxybutyl-b-CyD is useful for preparation of metastable forms and control of crystal habit of solid drugs.
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