Regulation of mast cell responses by environmental factors

• Project/Area Number: 23590077
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Okayama University
• Principal Investigator: TANAKA Satoshi 岡山大学, 医歯(薬)学総合研究科, 教授 (40303846)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: マスト細胞 / 線維芽細胞 / 共培養 / IgE / サイトカイン / 炎症 / アレルギー / ヒスタミン / ステロイド性抗炎症薬 / IL-6 / 分化 / Syk / Gfi1 / JNK / CD44 / ヒアルロン酸

Research Abstract

This study was performed to clarify the mechanism under which microenvironmental factors, such as neighboring cells, extracellular matrices, and IgE, regulate the terminal differentiation of murine tissue mast cells. Sensitivity to non-IgE stimulus was augmented during the maturation of mast cells, whereas the potentials to produce inflammatory cytokines were decreased in matured mast cells. Higher concentrations of IgE induced a transient increase in cytokine production but suppressed antigen-induced degranulation and inflammatory cytokine production.

Research Products

• [Journal Article] Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation. (2014)
  • Author(s): Morimoto, K., Shirata, N., Taketomi, Y., Tsuchiya, S., Segi-Nishida, E., Inazumi, T., Kabashima, K., Tanaka, S., Murakami, M., Narumiya, S., and Sugimoto, Y.
  • Journal Title: J. Immunol. Volume: 192 Issue: 3 Pages: 1130-1137
  • DOI: 10.4049/jimmunol.1300290
  • Peer Reviewed
• [Journal Article] T helper 2 and regulatory T cell cytokine production by mast cells: A key factor in the pathogenesis of IgG4-related disease. (2014)
  • Author(s): Takeuchi, M., Sato, Y., Ohno, K., Tanaka, S., Takata, K., Gion, Y., Orita,Y., Ito, T., Tachibana, T. and Yoshino, T.
  • Journal Title: Mod. Pathol. Volume: 27 Issue: 8 Pages: 1126-1136
  • DOI: 10.1038/modpathol.2013.236
  • Peer Reviewed
• [Journal Article] Regulation of Histamine Synthesis and Tryptase Expression through Transcription Factors, Growth Factor Independent 1 (Gfi1) and Gfi1b, in Murine Cultured Mast Cells (2014)
  • Author(s): Taura, A., Furuta, K., Yamaguchi, T., Kawabata, K., and Tanaka, S.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 37 Issue: 1 Pages: 81-86
  • DOI: 10.1248/bpb.b13-00616
  • NAID: 130003382104
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Histamine synthesis is required for granule maturation in murine mast cells. (2014)
  • Author(s): Nakazawa, S., Sakanaka, M., Furuta, K., Natsuhara, M., Takano, H., Tsuchiya, S., Okuno, Y., Ohtsu, H., Nishibori, M., Thurmond, R.L., Hirasawa, N., Nakayama, K., Ichikawa, A., Sugimoto, Y., and Tanaka, S.
  • Journal Title: Eur. J. Immunol. Volume: 44 Issue: 1 Pages: 204-214
  • DOI: 10.1002/eji.201343838
  • Peer Reviewed
• [Journal Article] 創薬の標的としてのマスト細胞 (2014)
  • Author(s): 田中 智之
  • Journal Title: MEDCHEM NEWS Volume: 24 Pages: 33-38
  • NAID: 130007741113
• [Journal Article] ヒスタミンとアナフィラキシー (2014)
  • Author(s): 田中 智之、古田 和幸
  • Journal Title: アレルギー・免疫 Volume: 20 Pages: 50-54
• [Journal Article] Mast cell maturation is driven via a novel group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. (2013)
  • Author(s): Taketomi, Y., Morimoto, K., Murakami, M., et al., 他30名
  • Journal Title: Nature Immunol. Volume: (印刷中) Issue: 6 Pages: 554-63
  • DOI: 10.1038/ni.2586
  • Peer Reviewed
• [Journal Article] Dextran Sulfate-induced degradation of spontaneously apoptic B cells. (2013)
  • Author(s): Kadota, Y., Sakai, N., Fujikawa, R., Aoyama, E., Zhong, M., Tanaka, S., and Gohda, E.
  • Journal Title: Int. Immunopharmacol. Volume: 15 Issue: 3 Pages: 581-587
  • DOI: 10.1016/j.intimp.2013.01.013
  • Peer Reviewed
• [Journal Article] Two-step differentiation of mast cells from induced pluripotent stem cells. (2013)
  • Author(s): Yamaguchi, T., Yamaguchi, T., Tashiro, K., Tanaka, S., Katayama, S., Ishida, W., Fukuda, K., Fukushima, A., Araki, R., Abe, M., Mizuguchi, H., Kawabata, K.
  • Journal Title: Stem Cells Dev. Volume: 22 Issue: 5 Pages: 726-734
  • DOI: 10.1089/scd.2012.0339
  • Peer Reviewed
• [Journal Article] Mitogen-activated protein kinases-dependent induction of hepatocyte growth factor production in human dermal fibroblasts by the antibiotic polymyxin B. (2012)
  • Author(s): Sugiyama Y, et al
  • Journal Title: Cytokine. Volume: 60 Issue: 1 Pages: 205-211
  • DOI: 10.1016/j.cyto.2012.06.007
  • Peer Reviewed
• [Journal Article] Restriction of Mast Cell Proliferation through Hyaluronan Synthesis by Co-cultured Fibroblasts (2012)
  • Author(s): Takano H, Furuta K, Yamashita K, Sakanaka M, Itano N, Gohda E, Nakayama K, Kimata K, Sugimoto Y, Ichikawa A., Tanaka S.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 35 Issue: 3 Pages: 408-412
  • DOI: 10.1248/bpb.35.408
  • NAID: 130001872324
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Presentation] Histamine synthesis and its functions in murine mast cells (2013)
  • Author(s): Satoshi Tanaka
  • Organizer: 42^<nd> Annual Meeting of the European Histamine Research Society
  • Place of Presentation: ポーランド
• [Presentation] HISTAMINE SYNTHESIS AND ITS FUNCTIONS IN MURINE MAST CELLS (2013)
  • Author(s): Satoshi Tanaka
  • Organizer: 42nd Annual Meeting of the European Histamine Research Society
  • Place of Presentation: ポーランド
  • Invited
• [Presentation] Mast cells as Microenvironmental Biosensors (2013)
  • Author(s): 田中 智之
  • Organizer: 2013 International Workshop on Biointerface and Biomedical Engineering
  • Place of Presentation: 岡山
• [Presentation] ハロゲン化ジニトロベンゼンによるマスト細胞の脱顆粒応答 (2013)
  • Author(s): 田中 智之、真鍋 洋平、柿木 彩、穂刈 敏史、吉村 麻里江、宮地 弘幸
  • Organizer: 第86回日本薬理学会
  • Place of Presentation: 福岡
• [Presentation] ハロゲン化ジニトロベンゼンによる脱顆粒応答の解析 (2012)
  • Author(s): 真鍋 洋平、柿木 彩、穂刈 敏史、吉村 麻里江、宮地 弘幸、田中 智之
  • Organizer: 第16回日本ヒスタミン学会
  • Place of Presentation: 岡山
• [Presentation] ヒスタミンを介するマスト細胞の顆粒成熟 (2012)
  • Author(s): 田中 智之
  • Organizer: 第85回日本薬理学会
  • Place of Presentation: 京都
• [Presentation] マスト細胞の機能制御とヒスタミン (2011)
  • Author(s): 田中智之
  • Organizer: 第61回日本アレルギー学会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-12
• [Presentation] マスト細胞の成熟過程におけるヒスタミンの機能 (2011)
  • Author(s): 田中智之
  • Organizer: 第15回日本ヒスタミン学会
  • Place of Presentation: 盛岡
  • Year and Date: 2011-10-21
• [Presentation] マスト細胞の顆粒形成におけるヒスタミンの機能 (2011)
  • Author(s): 田中智之
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] マスト細胞の顆粒形成におけるヒスタミンの機能 (2011)
  • Author(s): 田中 智之
  • Organizer: 第84回生化学会大会(招待講演)
  • Place of Presentation: 京都
• [Presentation] マスト細胞の成熟過程におけるヒスタミンの機能 (2011)
  • Author(s): 田中 智之
  • Organizer: 第15回日本ヒスタミン学会(招待講演)
  • Place of Presentation: 盛岡
• [Presentation] マスト細胞の機能制御とヒスタミン (2011)
  • Author(s): 田中 智之
  • Organizer: 第61回日本アレルギー学会(招待講演)
  • Place of Presentation: 東京
• [Presentation] マスト細胞の顆粒成熟におけるヒスタミンの機能 (2011)
  • Author(s): 田中 智之
  • Organizer: 第33回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 岡山
• [Remarks] 研究室ホームページ
  • URL: http://www.pharm.okayama-u.ac.jp/lab/meneki/
• [Remarks] 免疫生物学研究室
  • URL: http://www.pharm.okayama-u.ac.jp/lab/meneki/
• [Remarks] Department of Immunobiology
  • URL: http://www.cc.okayama-u.ac.jp/~tanaka-s/English/
• [Remarks] 岡山大学大学院医歯薬学総合研究科 生体応答制御学分野
  • URL: http://www.pharm.okayama-u.ac.jp/lab/meneki/
• [Remarks]
  • URL: http://www.cc.okayama-u.ac.jp/~tanaka-s/
• [Patent(Industrial Property Rights)] 成熟マスト細胞の製造方法 (2012)
  • Inventor(s): 田中 智之
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-09-24
  • Overseas
• [Patent(Industrial Property Rights)] 成熟マスト細胞の製造方法 (2011)
  • Inventor(s): 田中智之
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2011-209585
  • Filing Date: 2011-09-26
  • Overseas
• [Patent(Industrial Property Rights)] 成熟マスト細胞の製造方法 (2011)
  • Inventor(s): 田中 智之
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Number: 2011-209585
  • Filing Date: 2011