Study for sex differences of CYP3A enzymes using trans-chromosomic mice containing a human CYP3A gene cluster
| Project/Area Number |
23590170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
KOBAYASHI Kaoru 千葉大学, 薬学研究科(研究院), 准教授 (30255864)
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| Co-Investigator(Renkei-kenkyūsha) |
KAZUKI Yasuhiro 鳥取大学, 医学系研究科, 助教 (90403401)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | CYP3A / 遺伝子導入 / 性差 |
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| Research Abstract |
Results of this study using trans-chromosomic mice containing a human CYP3A gene cluster suggested that expression of CYP3A4 in liver shows sex differences and is positively regulated by estradiol. However, it is unlikely that estradiol directly regulates the CYP3A4 expression via estrogen receptor alpha. In addition, it was suggested that there are sex differences in induction of CYP3A4 expression in liver. Interestingly, no sex difference was observed in the intestinal expression and induction of CYP3A4. These findings demonstrated that sex differences in the hepatic expression of CYP3A4 are observed in trans-chromosomic mice containing a human CYP3A gene cluster, although it is hard to analyze the sex differences in human.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver2013
Author(s)
Hashimoto M, Kobayashi K, Watanabe M, Kazuki Y, Takehara S, Inaba A, Nitta S, Senda N, Oshimura M, Chiba K
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Journal Title
J Lipid Res
Volume: Vol. 54, No. 8
Pages: 2060-2068
Related Report
Peer Reviewed
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