| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
The aim of this study was to investigate whether the data-mining approach is useful for predicting the drug safety in humans, or not. The results showed that the drug transfer into breast milk and placental drug transfer in human were significantly predicted by the quantitative structure activity relationship (QSAR) models. The SVM method was revealed to be one of highly effective tools for classifying human toxicities of drugs into positive or negative, in silico.
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