• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Biopharmaceutical Study on Organic Solute Transporters Which Modulate Central Nervous System

Research Project

Project/Area Number 23590206
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionRitsumeikan University

Principal Investigator

FUJITA Takuya  立命館大学, 薬学部, 教授 (00247785)

Co-Investigator(Kenkyū-buntansha) 守屋 友加  名城大学, 薬学部, 助教 (00512295)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsトランスポーター / 中枢神経系 / 神経伝達物質 / 再取り込み / アストロサイト / TCA回路中間体 / 大脳皮質初代培養ニューロン / ジペプチドトランスポーター / ジ・トリカルボン酸トランスポーター / ニューロペプチド / 初代培養神経
Research Abstract

In vivo fate of amino acids and neurotransmitters in brain is precisely regulated by release from neuron and/or astrocytes and by their re-uptake, and is responsible for maintenance of brain high-order function. In this study, we investigated the functional characterization of N-acetyl-L-aspartyl-L-glutamate (NAAG) and carnitine transporter in mouse preimarily cultured neurons and astrocytes. NAAG was found to be taken up by oligopeptide transporter (PEPT) 2 in astrocytes. In addition, carnitine was found to be taken up by GABA transporter (GAT) 1 and carnitine/organic cation transporter (OCTN) 2 in neuron.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Studies on the Intestinal Absorption Characteristics of Sulfasalazine, a Breast Cancer Resistance Protein (BCRP) Substrate2013

    • Author(s)
      Atsuko Tomaru, Nozomi Morimoto, Mariko Morishita, Kozo Takayama, Takuya Fujita, Kazuya Maeda, Hiroyuki Kusuhara and Yuichi Sugiyama
    • Journal Title

      Drug Metab. Pharmacokinet

      Volume: 28 (1) Pages: 71-74

    • NAID

      130004463289

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Studies on the Intestinal Absorption Characteristics of Sulfasalazine, a Breast Cancer Resistance Protein (BCRP) Substrate2013

    • Author(s)
      Atsuko Tomaru, Nozomi Morimoto, Mariko Morishita, Kozo Takayama, Takuya Fujita, Kazuya Maeda, Hiroyuki Kusuhara and Yuichi Sugiyama
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 28 Issue: 1 Pages: 71-74

    • DOI

      10.2133/dmpk.DMPK-12-NT-024

    • NAID

      130004463289

    • ISSN
      1347-4367, 1880-0920
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetic interaction study of sulfasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP2012

    • Author(s)
      Hiroyuki Kusuhara, Hidetoshi Furuie, Akihiro Inano, Akihiro Sunagawa, Sakiko Yamada, Chungyong Wu, Shinya Fukizawa, Ichiro Ieiri, Mariko Morishita, Kiminobu Sumida, Hiroshi Mayahara, Takuya Fujita, Kazuya Maeda, and Yuichi Sugiyama
    • Journal Title

      Br. J. Pharmacol

      Volume: 166 (6) Pages: 1793-1803

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extra-renal Elimination of Uric Acid via Intestinal Efflux Transporter BCRP/ABCG22012

    • Author(s)
      Atsushi Hosomi, Takeo Nakanishi, Takuya Fujita, and Ikumi Tamai
    • Journal Title

      PLoS ONE

      Volume: 7 (2)

    • NAID

      120003959482

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetic interaction study of sulfasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP2012

    • Author(s)
      Kusuhara H, et al
    • Journal Title

      Br J Pharmacol

      Volume: (In press) Issue: 6 Pages: 1793-1803

    • DOI

      10.1111/j.1476-5381.2012.01887.x

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extra-renal Elimination of Uric Acid via Intestinal Efflux Transporter BCRP/ABCG2.2012

    • Author(s)
      Atsushi Hosomi, Takeo Nakanishi, Takuya Fujita, and Ikumi Tamai
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 2 Pages: e30456-e30456

    • DOI

      10.1371/journal.pone.0030456

    • NAID

      120003959482

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative evaluation of the impact of active efflux by P-gp and Bcrp at the BBB on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as surrogate2011

    • Author(s)
      Hiroshi Kodaira, Hiroyuki Kusuhara, Takuya Fujita, Junko Ushiki, Eiichi Fuse, and Yuichi Sugiyama
    • Journal Title

      J. Pharmacol. Exp. Ther

      Volume: 339 (3) Pages: 935-944

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intranasal immunization with poly(ɤ-glutamic acid) nanoparticles entrapping antigenic proteins can induce potent tumor immunity2011

    • Author(s)
      Keisuke Matsuo, Hayato Koizumi, Yumiko Ishii, Kazuhiko Matsuo, Takuya Fujita, Akira Yamamoto, Mitsuru Akashi, Shinsaku Nakagawa, and Naoki Okada
    • Journal Title

      J Control. Rel

      Volume: 152 (2) Pages: 310-316

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative evaluation of the impact of active efflux by P-gp and Bcrp at the BBB on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as surrogate.2011

    • Author(s)
      Hiroshi Kodaira, Hiroyuki Kusuhara, Takuya Fujita, Junko Ushiki, Eiichi Fuse, and Yuichi Sugiyama
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 339 Pages: 935-944

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] アロマターゼ阻害剤の脳実質移行性の比較2012

    • Author(s)
      楠原洋之、宮島真理、高橋佳代、高島忠之、細谷孝充、藤田卓也、渡辺恭良、杉山雄一
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2012-07-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Innovative strategies for drug development using microdosing clinical studies (NEDO microdose-PJ) 2011- (6)- Prediction of D2 receptor occupancy in the human brain by the recptor antagonists2011

    • Author(s)
      Chunyong Wu, Hiroyuki Kusuhara, Takuya Fujita, Yuichi Sugiyama
    • Organizer
      26^<th> JSSX Annual Meeting
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2011-11-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Intestinal active secretion of uric acid2011

    • Author(s)
      Atsushi Hosomi, Kouji Ikukawa, Takeo Nakanishi, Takuya Fujita, Ikumi Tamai
    • Organizer
      26^<th> JSSX Annual Meeting
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2011-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Characterizing deteminning factors for brain exposure of aromatase inhibitors2011

    • Author(s)
      Mari Miyajima, Hiroyuki Kusuhara, Kayo Tkahahashi, Takamitsu Hosoya, Tadayuki Takashima, Yasuyuki Watanabe, Takuya Fujita, John D. Schuetz, Yuichi Sugiyama
    • Organizer
      26^<th> JSSX Annual Meeting
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2011-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 各種動物種における薬物の消化管代謝の予測2011

    • Author(s)
      守屋友加、藤田卓也
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2011-05-31
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット門脈-全身血同時採血法による薬物の消化管吸収性評価とP-glycoproteinの寄与2011

    • Author(s)
      藤田卓也、守屋友加
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2011-05-31
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.ritsumei.ac.jp/pharmacy/fujita-t/home.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 立命館大学 研究者学術情報データベース

    • URL

      http://research-db.ritsumei.ac.jp/Profiles/40/0003910/theses1.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi