| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Collective cell movement is a widely observed biological event, and not a few parts of that are controlled by chemoattractants. A chemokine stromal cell-derived factor-1 (SDF-1), also known as CXCL12, functions as chemoattractant through its G-protein coupled receptor CXCR4. CXCR7, which was identified as a second receptor for SDF-1, has been focused since its novel roles have been reported as controlling cell migration to inhibit the signaling by sequestrating the SDF-1 and to signal via non-G-protein signaling pathway. In the present study, several lines of experiment suggest xCXCR7/SDF-1-dependent novel function that CXCR7 signaling modulates intercellular adhesion.
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