Analysis of the epithelial-mesenchymal transition (EMT) mechanism by utilizing neural crest cell generation model.
| Project/Area Number |
23590233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Gifu University |
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Principal Investigator |
MOTOHASHI Tsutomu 岐阜大学, 医学(系)研究科(研究院), 講師 (40334932)
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| Co-Investigator(Renkei-kenkyūsha) |
WAKAOKA Takanori 岐阜大学, 大学院医学系研究科, 大学院生
KITAGAWA Daisuke 岐阜大学, 大学院医学系研究科, 大学院生
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 上皮-間葉系転換 / 神経堤細胞 / 転写因子Sox10 / ES細胞 / 遺伝子改変マウス |
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| Research Abstract |
We identified the up-regulated genes in epithelial-mesenchymal transition (EMT) by utilizing the embryonic stem cells and mice, where the expression of Sox10 can be visualized with a fluorescent protein. Among these genes, we found the transcription factors that enhanced EMT. In addition, we found that glycoprotein Galectin-1 enhanced neural crest cell generation.
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Report
(4 results)
Research Products
(31 results)
