Transcriptional mechanism for maintenance and differentiation of neural stem cells
Project/Area Number |
23590237
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General anatomy (including Histology/Embryology)
|
Research Institution | Niigata University |
Principal Investigator |
|
Research Collaborator |
USUI Noriyoshi
BEPARI Asim
|
Project Period (FY) |
2011-04-28 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | オリゴデンドロサイト / 分化 / ミエリン / コンディショナルノックアウトマウス / 転写因子 / Olig2 / リン酸化 / 結合因子 |
Outline of Final Research Achievements |
Oligodenrocytes are glial cells in the central nervous system which are produced from neural stem cells during neural development. Olig2 is an essential transcription factor for oligodendrocyte development.In this study, we screened Olig2-binding proteins. We identified Olig2 binding proteins (OBP1 and OBP2). Overexpression experiment of OBP2 in embryonic mouse brain resulted in elevated expression of myelin-related genes. In addition, generation of central nervous system (CNS)-specific conditional knockout mice resulted in postnatal lethality with CNS abnormality.
|
Report
(6 results)
Research Products
(25 results)
-
-
[Journal Article] Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2.2014
Author(s)
Ono K., Clavairoly A., Nomura T., Gotoh H., Uno A., Armant O., Takebayashi H., Zhang Q., Shimamura K., Itohara S., Parras C.M., Ikenaka K.
-
Journal Title
Development
Volume: 141
Issue: 10
Pages: 2075-2084
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Disruption of actin-binding domain-containing Dystonin protein causes dystonia musculorum in mice.2014
Author(s)
Horie, M., Watanabe, K., Bepari, A. K., Nashimoto, J., Araki, K., Sano, H., Chiken, S., Nambu, A., Ono, K., Ikenaka, K., Kakita, A., Yamamura, K. and Takebayashi, H.
-
Journal Title
Eur. J Neurosci.
Volume: 40
Issue: 10
Pages: 3458-3471
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.2012
Author(s)
Lee DA, Bedont JL, Pak T, Wang H, Song J, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H, Aja S, Ford E, Fishell G, Blackshaw S.
-
Journal Title
Nat Neurosci
Volume: 15
Issue: 5
Pages: 700-702
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Presentation] 脳のできるしくみから学ぶ2015
Author(s)
竹林浩秀
Organizer
第16回 日本早期認知症学会学術大会
Place of Presentation
朱鷺メッセ(新潟県新潟市)
Year and Date
2015-10-10
Related Report
Invited
-
-
-
-
-
-
-
-
-
-
-
-