Shared mechanisms of the transcription factor IRF8 and the cAMP pathway in macrophage differentiation
| Project/Area Number |
23590343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
NISHIYAMA Akira 横浜市立大学, 医学(系)研究科(研究院), 准教授 (80589664)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Tomohiko 横浜市立大学, 医学研究科, 教授 (50285144)
ICHINO Motohide 横浜市立大学, 医学部, 助教 (60271368)
HOTTA Chie 横浜市立大学, 医学部, 助教 (80363810)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞内シグナル伝達 / 血球分化 / 転写因子 / 遺伝子発現 / 網羅的解析 / 免疫学 / マイクロアレイ / シグナル伝達 |
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| Research Abstract |
Cell differentiation requires appropriate changes in gene expression patterns, which are tightly regulated by cell type-specific transcription factors. Dysregulation of these processes can result in disorders incuding leukemias. IRF8 is a hematopoietic transcription factor that regulates the development of multiple immune cell types, and also it is considered as an important regulatory factor for chronic myelogenous leukemia. In this study, we have investigated the differentiation program of myeloid cells by functional analyses of IRF8 with the aim of the future clinical application for chronic myelogenous leukemia. We performed gene expression profiling of macrophage differentiation induced by multiple procedures including IRF8 ectopic expression. We found the common transcription factors in macrophage differentiation induced by multiple procedures. Indeed, the ectopic expression of these transcription factors induced macrophage differentiation without IRF8 expression.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] The transcription factor IRF8 counteracts BCR-ABL to rescue dendritic cell development in chronic myelogenous leukemia.2013
Author(s)
Watanabe T, Hotta C, Koizumi S, Miyashita K, Nakabayashi J, Kurotaki D, Sato GR, Yamamoto M, Nakazawa M, Fujita H, Sakai R, Fujisawa S, Nishiyama A, Ikezawa Z, Aihara M, Ishigatsubo Y, Tamura T.
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Journal Title
Cancerresearch
Volume: 73(22)
Issue: 22
Pages: 6642-53
DOI
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Peer Reviewed
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[Presentation] The transcription factor IRF8 rescues the dendritic cell development impaired by p210 Bcr/Abl.2011
Author(s)
Watanabe T, Hotta C, Sato GR, Yamamoto M, Fujita H, Sakai R, Fujisawa S, Nishiyama A, Aihara M, Ishigatsubo Y, Tamura T
Organizer
第34回日本分子生物学会年会
Place of Presentation
パシフィコ横浜（神奈川県）
Related Report
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[Presentation] The IRF8-KLF4 transcription factor cascade critically regulates the development of inflammatory monocytes
Author(s)
Kurotaki D., Osato N., Nishiyama A., Yamamoto M., Ban T., Sato H., Nakabayashi J., Umehara M., Nakazawa M., Miyake N., Matsumoto N., Ozato K., Tamura T.
Organizer
The Joint International Meeting of the Japanese Society for Interferon and Cytokine Research and Macrophage Molecular and Cellular Biology 2013
Place of Presentation
都市センターホテル（東京都）
Related Report
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[Presentation] The transcription factor IRF8 overrides BCR-ABL to rescue dendritic cell development in chronic myeloid leukemia.
Author(s)
Watanabe T., Hotta C., Koizumi S., Miyashita K., Nakabayashi J., Kurotaki D., Sato R. G., Yamamoto M., Nishiyama A., Aihara M., Ishigatsubo Y., Tamura T.
Organizer
2013 Inaugural Meeting of the International Cytokine and Interferon Society
Place of Presentation
Hyatt Regency San Francisco（米国）
Related Report
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[Presentation] The IRF8-KLF4 transcription factor cascade is essential for the development of monocytes
Author(s)
Kurotaki D., Osato N., Nishiyama A., Yamamoto M., Ban T., Sato H., Nakabayashi J., Umehara M., Nakazawa M., Miyake N., Matsumoto N., Ozato K., Tamura T.
Organizer
2013 Inaugural Meeting of the International Cytokine and Interferon Society
Place of Presentation
Hyatt Regency San Francisco（米国）
Related Report
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[Presentation] IRF8 inhibits the activity of C/EBP to restrain the neutrophil differentiation program in monocyte-dendritic cell progenitors.
Author(s)
Kurotaki D., Yamamoto M., Nishiyama A., Uno K., Ichino M., Sasaki H., Ban T., Yoshinari M., Nakazawa M., Ozato K., Tamura T.
Organizer
第36回日本分子生物学会年会
Place of Presentation
神戸国際会議場（兵庫県）
Related Report
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[Presentation] The transcription factor IRF8 is a key transcription factor for basophil development
Author(s)
Kurotaki D., Sasaki H., Osato N., Sasaki I., Kaneda C., Sato H., Nishiyama A., Kaisho T., Aburatani H., Morse H.C. 3rd., Ozato K., Tamura T.
Organizer
55th American Society of Hematology Annual Meeting and Exposition
Place of Presentation
Ernest N. Morial Convention Center（米国）
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