Significance of estrogen on biliary epithelial cells in the pathogenesis of primary biliary cirrhosis
| Project/Area Number |
23590393
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 原発性胆汁性肝硬変 / 胆管 / エストロゲン / エストロゲン受容体 / 病理学 / エストロゲン関連受容体 / 代謝 / 慢性非化膿性破壊性胆管炎 / AP-1 / 培養細胞 |
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| Research Abstract |
Primary biliary cirrhosis mainly affects middle- and old-aged females, and the interlobular bile ducts are primarily damaged. Estrogen has been speculated to play important roles in the pathogenesis of primary biliary cirrhosis, since biliary epithelial cells are known to express estrogen receptors. In primary biliary cirrhosis, the decreased estrogen effects caused by menopause and also the competitive inhibitory effect of estrogen-related receptors in biliary epithelial cells are associated with the pathogenesis of cholanigopathy.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems2013
Author(s)
Kakuda Y, Harada K, Sawada-Kitamura S, Ikeda H, sato Y, Sasaki M, Okafuji H, Mizukosi E, Terasaki S, Ohta H, Kasashima S, Kawashima A, Kaizaki Y, Kaneko S, Nakanuma Y
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Journal Title
Hum Pathol
Volume: 44(6)
Pages: 1107-17
NAID
Related Report
Peer Reviewed
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[Journal Article] Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis.2013
Author(s)
Aiba Y, Harada K, Komori A, Ito M, Shimoda S, Nakamura H, Nagaoka S, Abiru S, Migita K, Ishibashi H, Nakanuma Y, Nishida N, Kawashima M, Tokunaga K, Yatsuhashi H, Nakamura M.
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Journal Title
Liver Int.
Volume: 34
Issue: 5
Pages: 679-688
DOI
Related Report
Peer Reviewed
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[Journal Article] Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems.2013
Author(s)
Kakuda Y, Harada K, Sawada-Kitamura S, Ikeda H, Sato Y, Sasaki M, Okafuji H, Mizukoshi E, Terasaki S, Ohta H, Kasashima S, Kawashima A, Kaizaki Y, Kaneko S, Nakanuma Y.
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Journal Title
Hum Pathol
Volume: -
Issue: 6
Pages: 1107-1117
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Significance of periductal Langerhans cells and biliary epithelial cell-derived macrophage inflammatory protein-3αin the pathogenesis of primary biliary cirrhosis2011
Author(s)
Harada K, Shimoda S, Ikeda H, Chiba M, Hsu M, Sato Y, Kobayashi M, Ren X S, Ohta H, Kasashima S, Kawashima A, Nakanuma Y
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Journal Title
Liver Int
Volume: 31(2)
Pages: 245-53
Related Report
Peer Reviewed
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[Presentation] 原発性胆汁性肝硬変の肝局所におけるTL1A産生機構の解明2013
Author(s)
相葉佳洋, 原田憲一, 小森敦正, 阿比留正嗣, 長岡進矢, 右田清志, 伊東正博, 中沼安二, 八橋弘, 中村稔
Organizer
第50回日本消化器免疫学会総会
Place of Presentation
ホテルグランドヒル市ヶ谷, 東京都
Related Report
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[Presentation] 各種自己抗体および新病期分類から見た原発性胆汁性肝硬変の治療反応性2013
Author(s)
吉田真理子, 太田肇, 羽柴智美, 矢野正明, 丹尾幸樹, 丸川洋平, 川島篤弘, 角田優子, 原田憲一, 中沼安二
Organizer
第49回日本肝臓学会総会
Place of Presentation
京王プラザホテル, 東京都
Related Report
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