Analysis of mechanisms by which malignant pleural mesothelioma grows and invades: application to pathological diagnosis and development of a new therapy
| Project/Area Number |
23590438
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TORII Ikuko 兵庫医科大学, 医学部, 准教授 (70207661)
SATO Ayuko 兵庫医科大学, 医学部, 講師 (20419823)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 悪性胸膜中皮腫 / 上皮間葉転換 / 浸潤 / Polycomb遺伝子群 / EZH2 / 予後 |
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| Research Abstract |
Malignant mesothelioma is characterized by diffuse growth in the thoracic cavity and invasive proliferation in the chest wall, leading to poor prognosis. To clarify the mechanism by which malignant mesothelioma develops these features, we compared the gene expression profiling between malignant mesothelioma and mesothelial cells. We found that EZH2, which contributes to epigenetic silencing of target genes, was expressed at higher levels in malignant mesothelioma than in mesothelial cells. When EZH2 expression in mesothelioma cells was suppressed by the introduction of EZH2-siRNA, proliferation of these cells decreased. Immunohistochemical analysis of EZH2 expression in surgical specimens of malignant mesothelioma revealed correlation between higher expression of EZH2 and shorter overall survival of patients. It seems that epigenetics participates in biological characteristics of malignant mesothelioma, such as the growth in the thoracic cavity and the invasion into the chest wall.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascad2014
Author(s)
Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y
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Journal Title
Oncogene
Volume: 34
Issue: 1
Pages: 73-83
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Significant increase in circulating tumour cells in pulmonary venous blood during surgical manipulation in patients with primary lung cancer.2014
Author(s)
Hashimoto M, Tanaka F, Yoneda K, Takuwa T, Matsumoto S, Okumura Y, Kondo N, Tsubota N, Tsujimura T, Tabata C, Nakano T, Hasegawa S.
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Journal Title
Interact Cardiovasc Thorac Surg
Volume: 18
Issue: 6
Pages: 775-783
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Circulating Tumor Cells (CTCs) in Malignant Pleural Mesothelioma (MPM).2013
Author(s)
Yoneda K, Tanaka F, Kondo N, Hashimoto M, Takuwa T, Matsumoto S, Okumura Y, Tsubota N, Sato A, Tsujimura T, Kuribayashi K, Fukuoka K, Tabata C, Nakano T, Hasegawa S.
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Journal Title
Ann Surg Oncol
Volume: -
Issue: S4
Pages: 472-480
DOI
Related Report
Peer Reviewed
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[Journal Article] TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth2012
Author(s)
Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, Hida T, Tsujimura T, Osada H, Sekido Y.
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Journal Title
J Exp Med
Volume: VOL.209(3)
Issue: 3
Pages: 479-494
DOI
Related Report
Peer Reviewed
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[Journal Article] Frequent deletion of 3p21.1 region carrying semaphorin 3G and aberrant expression of the genes participating in semaphorin signaling in the epithelioid type of malignantmesothelioma cells2011
Author(s)
Yoshikawa Y, Sato A, Tsujimura T, Morinaga T, Fukuoka K, Yamada S, Murakami A, Kondo N, Matsumoto S, Okumura Y, Tanaka F, Hasegawa S, Hashimoto-Tamaoki T, and Nakano T.
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Journal Title
Int J Oncol.
Volume: 39(6)
Pages: 1365-74
DOI
Related Report
Peer Reviewed
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