|Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|Outline of Final Research Achievements
Histidine decarboxylase (HDC) deficient mice show decreased atherosclerotic lesions. The HDC-KO mice also exhibit suppression of osteoporosis after ovariectomy. Therefore, histamine metabolism would be related to both the pathogenesis of vascular and bone lesions in low estrogen condition such as menopaused women. When HDC or H2R deficient mice fed high fat diet after ovariectomy, the density of bone trabeculae was decreased in the femur. This indicated that histamine H2R signaling would regulate the maintenance of bone volume, however, in this study, no exact relation to the atherogenesis was noted.