| Project/Area Number |
23590490
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
ARAKAWA Takeshi 琉球大学, 熱帯生物圏研究センター, 准教授 (50305190)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Takeshi 鹿児島大学, 農学部, 助教 (20448591)
山田 清太郎 琉球大学, 熱帯生物圏研究センター, 研究員 (70650258)
|
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| Co-Investigator(Renkei-kenkyūsha) |
TSUBOI Takafumi 愛媛大学, プロテオサイエンスセンター, 教授 (00188616)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ワクチン / 免疫 / マラリア / 熱帯感染症 / タイ国 / 国際情報交換 / 組換えタンパク質 / アジュバント / 三部構成免疫賦活複合体 / 伝搬阻止ワクチン / 三日熱マラリア原虫 / デリバリー機能 |
|---|
| Research Abstract |
Development of subunit vaccines to prevent malaria infection has been hampered by the intrinsic weak immunogenicity of the recombinant malaria antigens. We have establised a novel system called tricomponent immunopotentiating system (TIPS) to increase immune responses by creating genetic protein fusions to target B lymphocytes in the draining lymph nodes of immunized animals. TIPS is composed of the antigen, coiled-coil core and the targeting ligand. We found that integration of vaccine antigens in the TIPS significantly augmented the immunogenicity and vaccine efficacy of the antigens.
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