Immune response in the zinc-deficient mice infected with murine malaria.

• Project/Area Number: 23590491
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: University of the Ryukyus
• Principal Investigator: WATANABE HISAMI 琉球大学, 熱帯生物圏研究センター, 教授 (50143756)
• Co-Investigator(Kenkyū-buntansha): LI Changchun 琉球大学, 亜熱帯島嘆科学超域研究推進機構, 助教 (20457691)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ネズミマラリア / 亜鉛欠乏 / 自然免疫機構 / Th2サイトカイン / 原虫特異抗体産性能 / 獲得免疫機構

Research Abstract

Malaria is one of the most serious infectious diseases worldwide. Therefore, there were many reports suggested the importance of nutritional status to maintain the immunity against pathogens. In particular, zinc is known to play a critical role in responding to infections including malaria. We have examined the relationship between zinc deficiency and murine malaria infection. The objective of this study is to explore the effect of zinc deficiency to the immunity against malaria.
Mice fed with zinc deficient diet were infected with murine malaria parasites and the immunological parameters were sequentially analyzed. The results of this study indicated the zinc deficiency might affect the immune responses to malaria. The following is suggested; in early phase of infection, both innate immunity and phagocytic activities of macrophages can be maintained. However, acquired immune system might fail to induce the production of malaria specific antibodies to eliminate the parasites.

Research Products

• [Journal Article] Association between serum zinc concentration and Plasmodium falciparum antibody titer among rural villagers of Attapeu Province, Lao People's Democratic Republic (2013)
  • Author(s): Akiyama, T., Taniguchi, T., Vanisaveth, V., Inamine, Y., Toma, N, Li C., Toma, H., Takeuchi R., Kobayashi, J., Kano, S., Hongvanthong, B., Watanabe, H.
  • Journal Title: Acta Trop Volume: 126 Pages: 193-197
  • Peer Reviewed
• [Journal Article] Induction of ssDNA-binding autoantibody secreating B cell immunity during murine malaria infection is a critical part of the protective immune responses (2013)
  • Author(s): Mannoor, K., Li, C., Inafuku, M., Taniguchi, T., Sato, Y., Watanabe, H.
  • Journal Title: Immunobiology Volume: 218 Pages: 10-20
  • Peer Reviewed
• [Journal Article] Association between serum zinc concentration and Plasmodium falciparum antibody titer among rural villagers of Attapeu Province, Lao People’s Democratic Republic (2013)
  • Author(s): Akiyama, T., Taniguchi, T., Vanisaveth, V., Inamine, Y., Toma, N, Li C., Toma, H., Takeuchi R., Kobayashi, J., Kano, S., Hongvanthong, B., Watanabe, H.
  • Journal Title: Acta Trop. Volume: 126 Pages: 193-197
  • Peer Reviewed
• [Journal Article] nduction of ssDNA-binding autoantibody secreating B cell immunity during murine malaria infection is a critical part of the protective immune responses. (2013)
  • Author(s): Mannoor, K., Li, C., Inafuku, M., Taniguchi, T., Sato, Y., Watanabe, H.
  • Journal Title: Immunobiology Volume: 218 Issue: 1 Pages: 10-20
  • DOI: 10.1016/j.imbio.2012.01.018
  • Peer Reviewed
• [Journal Article] Immunosuppressive function of dendritic cells existed in the liver (2012)
  • Author(s): Tomiyama, C., Watanabe, H., Watanabe, M., Abo, T.
  • Journal Title: Curr. Res. Immunol. Volume: 6 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Biology of autoreactive extrathymic T cells and B-1 cells of the innate immune system (2012)
  • Author(s): Abo, T., Tomiyama, C., Watanabe, H.
  • Journal Title: Immunol. Res. Volume: 52 Pages: 224-230
  • Peer Reviewed
• [Journal Article] Protective function of an unconventional γбT cell subset against malaria infection in apoptosis inhibitor deficient mice (2012)
  • Author(s): Li, C., Mannoor, K., Inafuku, M., Taniguchi, T., Inamine, Y., Miyazaki, T., Watanabe, H.
  • Journal Title: Cell. Immunol. Volume: 279 Pages: 151-159
  • Peer Reviewed
• [Journal Article] Protective function of an unconventional γδ T cell subset against malaria infection in apoptosis inhibitor deficient mice. (2012)
  • Author(s): Li, C., Mannoor, K., Inafuku, M., Taniguchi, T., Inamine, Y., Miyazaki, T., Watanabe, H.
  • Journal Title: Cell. Immunol. Volume: 279 Pages: 151-159
  • Peer Reviewed
• [Journal Article] Immunosuppressive function of dendritic cells existed in the liver. (2012)
  • Author(s): Tomiyama, C., Watanabe, H., Watanabe, M., Abo, T.
  • Journal Title: Curr. Res. Immunol. Volume: 6 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Efficacy of mefloquine treatment and genetic profiles in uncomplicated Plasmodium falciparum malaria in southern Lao PDR (2011)
  • Author(s): Toma, H., Hatabu, T., Vanisaveth V., Mannoor, K., Watanabe, H., Li, C., Kobayashi, J., Phompida, S., Kano, S., Sato, Y.
  • Journal Title: Southeast Asian J. Trop. Med. Public Health Volume: 42 Pages: 759-763
  • Peer Reviewed
• [Journal Article] Suppressive role of hepatic dendritic cells in concanavalin A-induced hepatitis (2011)
  • Author(s): Tomiyama, C., Watanabe, H., Izutsu, Y., Watanabe, M., Abo, T.
  • Journal Title: Clin. Exp. Immunol. Volume: 166 Pages: 258-268
  • Peer Reviewed
• [Journal Article] Efficacy of mefloquine treatment and genetic profiles in uncomplicated Plasmodium falciparum malaria in southern Lao PDR. (2011)
  • Author(s): Toma, H., Hatabu, T., Vanisaveth V., Mannoor, K., Watanabe, H., Li, C., Kobayashi, J., Phompida, S., Kano, S., Sato, Y.
  • Journal Title: Southeast Asian J. Trop. Med. Public Health Volume: 42 Pages: 759-763
  • Peer Reviewed
• [Journal Article] Suppressive role of hepatic dendritic cells in concanavalin A-induced hepatitis. (2011)
  • Author(s): Tomiyama, C., Watanabe, H., Izutsu, Y., Watanabe, M., Abo, T.
  • Journal Title: Clin. Exp. Immunol. Volume: 166 Pages: 258-268
  • Peer Reviewed
• [Presentation] Analysis of the mechanism of anemia and the importance of extra-medullary erythropoiesis in murine malaria (2014)
  • Author(s): 李長春、稲嶺由羽、渡部久実
  • Organizer: 第83回日本寄生虫学会大会
  • Place of Presentation: 愛媛
• [Presentation] Analysis of the mechanism of anemia and the importance of extra-medullary erythropoiesis in murine malaria (2014)
  • Author(s): 李 長春、稲嶺由羽、渡部久実
  • Organizer: 第83回日本寄生虫学会大会
  • Place of Presentation: 愛媛大学 城北キャンパス、愛媛
• [Presentation] Sero-epidemiological survey of malaria in the border area of Quang Tri Province, Vietnam (2013)
  • Author(s): Watanabe, H.
  • Organizer: The 4th International Symposium on Human Monkey Malaria in Vietnam
  • Place of Presentation: Nagasaki, Japan
• [Presentation] Genetic analysis of HIV-1 subtypes and drug resistance mutations in Savannakhet Province, Lao PDR (2013)
  • Author(s): Phongmany, P., Watanabe, T., Araki, M., Sourinphomy, K., Watanabe, H., Sopraseuth V., Moji, K., Southalack P., Nhativong K., Kobayashi, J.
  • Organizer: The 11th International Congress on AIDS in Asia and the Pacific
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Sero-epidemiological survey of malaria in the border area of Quang Tri Province, Vietnam. (2013)
  • Author(s): Watanabe, H.
  • Organizer: The 4th International Symposium on Human Monkey Malaria in Vietnam
  • Place of Presentation: Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
• [Presentation] Genetic analysis of HIV-1 subtypes and drug resistance mutations in Savannakhet Province, Lao PDR. (2013)
  • Author(s): 2. Phongmany, P., Watanabe, T., Araki, M., Sourinphomy, K., Watanabe, H., Sopraseuth V., Moji, K., Southalack P., Nhativong K., Kobayashi, J.
  • Organizer: The 11th International Congress on AIDS in Asia and the Pacific
  • Place of Presentation: Queen Sirikit National Convention Center, Bangkok, Thailand
• [Presentation] Multifactorial anemia and induction of exta-medullary erythropoiesis in murine malaria (2012)
  • Author(s): Li, C., Inamine, Y., Watanabe, H.
  • Organizer: 第81回日本寄生虫学会大会
  • Place of Presentation: 西宮
• [Presentation] マウスモデルにおける低亜鉛状態下のマラリア感染時の免疫動態について (2012)
  • Author(s): 稲嶺由羽、李長春、稲福征志、渡部久実
  • Organizer: 第81回日本寄生虫学会大会
  • Place of Presentation: 西宮
• [Presentation] Asymptomatic malaria and anemia among children in Savannakhet Province, Lao PDR (2012)
  • Author(s): Akiyama, T., Taniguchi, T., Inamine, Y., Takeuchi, R., Moji, K., Kano, S., Pongvongsa, T., Watanabe, H.
  • Organizer: 5th ASEAN Congress of Tropical Medicine and Parasitology
  • Place of Presentation: Manila,Philippine
• [Presentation] Field research: Micronutrient status and malaria infection among rural villages of Lao PDR (2012)
  • Author(s): Akiyama, T., Taniguchi, T., Toma, H., Inamine, Y., Takeuchi, R., Kobayashi, J., Kano, S., Pongvongsa, T., Vanisaveth, V., Hongvanthog, B., Watanabe, H.
  • Organizer: 18th International Congress for Tropical medicine and Malaria
  • Place of Presentation: Rio de Janeiro, Brazil
• [Presentation] Quang Try Report: Molecular and Sero-epidemiology of malaria in the border area of Quang Tri Province, Vietnam (2012)
  • Author(s): Watanabe, H.
  • Organizer: The 3rd International Symposium on Human Monkey Malaria in Vietnam
  • Place of Presentation: Inuyama, Japan
• [Presentation] Immune responses to malaria in a mouse model of zinc deficiency (2012)
  • Author(s): Inamine, Y., Li, C., Watanabe, H.
  • Organizer: 第41回日本免疫学会総会
  • Place of Presentation: 神戸
• [Presentation] Asymptomatic malaria and anemia among children in Savannakhet Province, Lao PDR. (2012)
  • Author(s): Akiyama, T., Taniguchi, T., Inamine, Y., Takeuchi, R., Moji, K., Kano, S., Pongvongsa, T., Watanabe, H.
  • Organizer: 5th ASEAN Congress of Tropical Medicine and Parasitology
  • Place of Presentation: Manila, Philippine
• [Presentation] Field research: Micronutrient status and malaria infection among rural villages of Lao PDR. (2012)
  • Author(s): Akiyama, T., Taniguchi, T., Toma, H., Inamine, Y., Takeuchi, R., Kobayashi, J., Kano, S., Pongvongsa, T., Vanisaveth, V., Hongvanthog, B., Watanabe, H.
  • Organizer: 8th International Congress for Tropical medicine and Malaria
  • Place of Presentation: Rio de Janeiro, Brazil
• [Presentation] uang Try Report: Molecular and Sero-epidemiology of malaria in the border area of Quang Tri Province, Vietnam. (2012)
  • Author(s): Watanabe, H.
  • Organizer: The 3rd International Symposium on Human Monkey Malaria in Vietnam
  • Place of Presentation: Inuyama, Japan
• [Presentation] mmune responses to malaria in a mouse model of zinc deficiency. (2012)
  • Author(s): Inamine, Y., Li, C., Watanabe, H.
  • Organizer: 第41回日本免疫学会総会
  • Place of Presentation: 神戸
• [Presentation] Multifactorial anemia and induction of exta-medullary erythropoiesis in murine malaria. (2012)
  • Author(s): Li, C., Inamine, Y., Watanabe, H.
  • Organizer: 第81回日本寄生虫学会大会
  • Place of Presentation: 西宮（兵庫）
• [Presentation] マウスモデルにおける低亜鉛状態下のマラリア感染時の免疫動態について (2012)
  • Author(s): 稲嶺由羽、李長春、稲福征志、渡部久実
  • Organizer: 第81回日本寄生虫学会大会
  • Place of Presentation: 西宮（兵庫）
• [Presentation] Asymptomatic malaria, growth status and anemia among children in Savannakhet Province, Lao PDR (2011)
  • Author(s): Akiyama, T., Taniguchi, T., Inamine, Y., Takeuchi, R., Moji, K., Kano, S., Watanabe, H.
  • Organizer: The 5th National Health Research Forum to Promote the Health Research System Strengthening in Lao PDR
  • Place of Presentation: Vientiane, Lao PDR
• [Presentation] 低亜鉛飼料給餌マウスにおけるマラリアに対する感染防御能の解析 (2011)
  • Author(s): 稲嶺由羽、李長春、稲福征志、渡部久実
  • Organizer: 第22回日本生体防御学会学術総会
  • Place of Presentation: 那覇
• [Presentation] Induction of ssDNA-binding autoantibody secreting B cell immunity during murine malaria infection is a critical part of the protective immunere sponses (2011)
  • Author(s): Li C., Mannoor, K., Watanabe, H.
  • Organizer: 第22回日本生体防御学会学術総会
  • Place of Presentation: 那覇
• [Presentation] The importan t role of ssDNA-binding autoantibody secreting B cells in malaria infection (2011)
  • Author(s): 李長春、Mannoor,K.,稲福征志、渡部久塞
  • Organizer: 第80回日本寄生虫学会大会・第22回日本臨床寄生虫学会大会
  • Place of Presentation: 東京
• [Presentation] ラオス国サワナケート県における児童の成長状態と、不顕性マラリア感染び貧血について (2011)
  • Author(s): 秋山剛、谷口委代、稲嶺由羽、竹内理恵、門司和彦、狩野繁之、渡部久実
  • Organizer: 第52回日本熱帯医学会大会・第26回日本国際保健医療学会学術大会
  • Place of Presentation: 東京
• [Presentation] 低亜鉛飼料給餌マウスにおけるマラリア感染時の免疫動態について (2011)
  • Author(s): 稲嶺由羽、李長春、稲福征志、渡部久実
  • Organizer: 第52回日本熱帯医学会大会・第26回日本国際保健医療学会学術大会
  • Place of Presentation: 東京
• [Presentation] Protective function of autoantibody secreting B cells in murine malariain fection (2011)
  • Author(s): Li, C., Mannoor, K., Inafuku, M., Inamine, Y., Watanabe, H.
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 千葉
• [Presentation] Immune response in the zinc-deficient mice infected with murine malaria (2011)
  • Author(s): Inamine, Y., Li, C., Inafuku, M., Watanabe, H.
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 千葉
• [Presentation] The important role of ssDNA-binding autoantibody secreting B cells in malaria infection (2011)
  • Author(s): 李 長春、Mannoor, K., 稲福征志、渡部久実
  • Organizer: 第80回日本寄生虫学会大会・第22回日本臨床寄生虫学会大会
  • Place of Presentation: 東京
• [Presentation] nduction of ssDNA-binding autoantibody secreting B cell immunity during murine malaria infection is a critical part of the protective immune responses. (2011)
  • Author(s): Li, C., Mannoor, K., Watanabe, H.
  • Organizer: 第22回日本生体防御学会学術総会
  • Place of Presentation: 那覇（沖縄）
• [Presentation] 低亜鉛飼料給餌マウスにおけるマラリアに対する感染防御能の解析 (2011)
  • Author(s): 稲嶺由羽、李 長春、稲福征志、渡部久実
  • Organizer: 第22回日本生体防御学会学術総会
  • Place of Presentation: 那覇（沖縄）
• [Presentation] ラオス国サワナケート県における児童の成長状態と、不顕性マラリア感染及び貧血について (2011)
  • Author(s): 秋山 剛、谷口委代、稲嶺由羽、竹内理恵、門司和彦、狩野繁之、渡部久実
  • Organizer: 第52回日本熱帯医学会大会・第26回日本国際保健医療学会学術大会
  • Place of Presentation: 東京
• [Presentation] 亜鉛飼料給餌マウスにおけるマラリア感染時の免疫動態について (2011)
  • Author(s): 稲嶺由羽、李 長春、稲福征志、渡部久実
  • Organizer: 第52回日本熱帯医学会大会・第26回日本国際保健医療学会学術大会
  • Place of Presentation: 東京
• [Presentation] Protective function of autoantibody secreting B cells in murine malaria infection. (2011)
  • Author(s): Li, C., Mannoor, K., Inafuku, M., Inamine, Y., Watanabe, H.
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 千葉
• [Presentation] Immune response in the zinc-deficient mice infected with murine malaria. (2011)
  • Author(s): Inamine, Y., Li, C., Inafuku, M., Watanabe, H.
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 千葉
• [Presentation] Asymptomatic malaria, growth status and anemia among children in Savannakhet Province, Lao PDR.
  • Author(s): Akiyama, T., Taniguchi, T., Inamine, Y., Takeuchi, R., Moji, K., Kano, S., Watanabe, H.
  • Organizer: The 5th National Health Research Forum to Promote the Health Research System Strengthening in Lao PDR.
  • Place of Presentation: Vientiane, Lao PDR
• [Remarks]
  • URL: http://w3.u-ryukyu.ac.jp/immunobiology/index.html