Searching the ligands of NLRP3 and NLRC4
Project/Area Number |
23590513
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Bacteriology (including Mycology)
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Research Institution | Nara Women's University |
Principal Investigator |
OGURA Yasunori 奈良女子大学, 生活環境科学系, 教授 (60304557)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | NLRP3 / caspase-1 / IL-1beta / 自然免疫 / 炎症 / IL-1β / 感染 / Danger signal / NLRタンパク質 / インフラマソーム / NLRC4 |
Research Abstract |
In this proposal, I have aimed to identify the ligands of NLRP3 and NLRC4 proteins, which are regulators of the inflammatory caspase, caspase-1. Although I could not accomplish the final goal within the period, on the process of analysing the mechanism of the NLRP3 activation, I have gotten important progress to approach the signaling pathway that NLRP3 mediates; namely, (1) the NLRP3 activation coincides with the increase of intracellular ceramide; (2) chloride ions play an important role in the NLRP3 activation; (3) the extract from Zanthoxylum bungeanum inhibits the extracellular transport of the mature IL-1beta peptide.
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Report
(4 results)
Research Products
(9 results)
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[Presentation] 免疫と栄養
Author(s)
小倉裕範
Organizer
第10回日本栄養改善学会近畿支部学術総会
Place of Presentation
奈良市
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