• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Translational research of animal study and clinical trial for the mechanisms of weather-dependent pain aggravation.

Research Project

Project/Area Number 23590710
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionNagoya University

Principal Investigator

SATO JUN  名古屋大学, 動物実験支援センター, 教授 (00235350)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords気象変化 / 慢性痛 / 自律神経 / 内耳前庭 / 疼痛 / 気象 / うつ病 / 低温 / 低気圧
Research Abstract

The authors have clarified underlying mechanisms of weather-sensitive diseases in the basic study with animal and subjects. In the present research project, we have further progressed the animal study and had clinical study using chronic pain patients with their pain to be sensitive to weather change. This translational study clarified important roles of inner ear in the mechanism of weather-sensitive condition and provided a scientific link between laboratory research and human trials, and the beginning of discovery of therapeutic strategies for this syndrome.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (58 results)

All 2014 2013 2012 2011

All Journal Article (13 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (43 results) (of which Invited: 9 results) Book (2 results)

  • [Journal Article] Activated spinal astrocytes are involved in the maintenance of chronic widespread mechanical hyperalgesia after cast immobilization.2014

    • Author(s)
      Mika Ohmichi
    • Journal Title

      Molecular Pain

      Volume: 24 Pages: 6-6

    • DOI

      10.1186/1744-8069-10-6

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 痛みと自律神経2013

    • Author(s)
      佐藤純
    • Journal Title

      自律神経

      Volume: 50巻 Pages: 226-228

    • Related Report
      2013 Final Research Report
  • [Journal Article] 気象痛と対策2013

    • Author(s)
      佐藤純
    • Journal Title

      臨床整形外科

      Volume: 48巻 Pages: 458-460

    • Related Report
      2013 Final Research Report
  • [Journal Article] Neurolytic celiac plexus block reduces occurrence and duration of terminal delirium in patients with pancreatic cancer.2013

    • Author(s)
      ARAI Young-Chang P, NISHIHARA Makoto, KOBAYASHI Kunio, et al.
    • Journal Title

      Journal of Anesthesia

      Volume: 27(1) Issue: 1 Pages: 88-92

    • DOI

      10.1007/s00540-012-1486-3

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treadmill running and static stretching improve long-lasting hyperalgesia, joint limitation, and muscle atrophy induced by cast immobilization in rats.2013

    • Author(s)
      Morimoto A
    • Journal Title

      Neurosci Lett

      Volume: 534 Pages: 295-300

    • DOI

      10.1016/j.neulet.2012.11.009

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 気象病と対策2013

    • Author(s)
      佐藤 純
    • Journal Title

      臨床整形外科

      Volume: 48 Pages: 458-460

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 痛みと自律神経2013

    • Author(s)
      佐藤 純
    • Journal Title

      自律神経

      Volume: 50 Pages: 226-228

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The effect of celiac plexus block on heart rate variability2012

    • Author(s)
      Arai, Y. C.
    • Journal Title

      J Anesth

      Volume: 27 Issue: 1 Pages: 62-5

    • DOI

      10.1007/s00540-012-1467-6

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low barometric pressure aggravates neuropathic pain in guinea pigs2011

    • Author(s)
      Sato J, Itano Y, Funakubo M, Mizoguchi H, Itoh M, Mori R
    • Journal Title

      Neuroscience Letters

      Volume: 503(2) Issue: 2 Pages: 152-156

    • DOI

      10.1016/j.neulet.2011.08.030

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The rate and magnitude of atmospheric pressure change that aggravate pain-related behavior of nerve injured rats2011

    • Author(s)
      Funakubo M, Sato J, Obata K, Mizumura K
    • Journal Title

      International Journal of Biometeorology

      Volume: 55(3) Issue: 3 Pages: 319-326

    • DOI

      10.1007/s00484-010-0339-8

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative effects of acupressure at local and distal acupuncture points on pain conditions and autonomic function in females with chronic neck pain.2011

    • Author(s)
      Matsubara T, Arai YC, Shiro Y
    • Journal Title

      Evid Based Complement Alternat Med.

      Volume: (Article ID 543291) Issue: 1

    • DOI

      10.1155/2011/543291

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ストレスと痛み2011

    • Author(s)
      佐藤純
    • Journal Title

      ペインクリニック

      Volume: 32巻, No.12

    • Related Report
      2013 Final Research Report
  • [Journal Article] ストレスと痛み2011

    • Author(s)
      佐藤 純
    • Journal Title

      ペインクリニック

      Volume: 32(12) Pages: 1681-1687

    • Related Report
      2011 Research-status Report
  • [Presentation] 天気痛患者における前庭刺激を用いた知覚閾値測定2014

    • Author(s)
      青野修一, 櫻井博紀, 齋藤愛子, 戸田真弓, 牛田享宏, 佐藤純
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-03-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 天気痛患者における前庭電気刺激を用いた知覚閾値測定2014

    • Author(s)
      青野修一,櫻井博紀,齋藤愛子,戸田真弓,牛田享宏,佐藤 純
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 気圧変化を感受する機構には内耳前庭が関与する2013

    • Author(s)
      佐藤純
    • Organizer
      第59回日本宇宙航空環境医学大会
    • Place of Presentation
      倉敷
    • Year and Date
      2013-11-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 天気と痛み自律神経の関わり2013

    • Author(s)
      佐藤純
    • Organizer
      第66回日本自律神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-10-24
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] ラット神経障害性疼痛モデルと抑うつモデルの寒冷曝露に対するノルアドレナリン反応2013

    • Author(s)
      勝田紘基, 志水泰夫, 深谷由美, 大和恵子, 児玉幸二, 溝口博之, 佐藤純
    • Organizer
      第35回日本疼痛学会
    • Place of Presentation
      大宮
    • Year and Date
      2013-07-13
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 第22回神経行動薬理若手研究者の集いシンポジウム次世代に向けての行動薬理学とその新展開2013

    • Author(s)
      溝口博之, 福本和哉, 王天, 佐藤純, 山田清文
    • Organizer
      第22回神経行動薬理若手研究者の集いシンポジウム次世代に向けての行動薬理学とその新展開
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 天気と痛み 自律神経の関わり2013

    • Author(s)
      佐藤 純
    • Organizer
      第66回日本自律神経学会総会純
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 気圧変化を感受する機構には内耳前庭が関与する2013

    • Author(s)
      佐藤 純
    • Organizer
      第59回日本宇宙航空環境医学会大会
    • Place of Presentation
      倉敷
    • Related Report
      2013 Annual Research Report
  • [Presentation] 薬物依存モデル動物の近視眼的意思決定2013

    • Author(s)
      溝口博之, 福本和哉, 王 天, 佐藤 純, 山田清文
    • Organizer
      第22回神経行動薬理 若手研究者の集い, シンポジウム「次世代に向けての行動薬理学とその新展開」
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 姿勢運動パターンによる運動器慢性疼痛患者評価の試み2012

    • Author(s)
      櫻井博紀, 井上雅之, 森本温子, 大道裕介, 井上真輔, 池本竜則, 新井健一, 西原真理, 佐藤純, 牛田享宏
    • Organizer
      第5回日本運動器疼痛学会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 気圧センシングメカニズムにおけるTRPチャネルの役割2012

    • Author(s)
      村松寛惟, 佐藤純
    • Organizer
      第51回日本生気象学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-11-09
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 痛みと自律神経系2012

    • Author(s)
      佐藤純
    • Organizer
      第65回日本自律神経学会総会シンポジウム4しびれ・痛みと自律神経障害
    • Place of Presentation
      東京
    • Year and Date
      2012-10-25
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Increase in cold sensitivity of heart rate in a mouse model of anxiety/ depression2012

    • Author(s)
      Sato J, Mizutani Y, Mizoguchi H, Kodama K, Itoh M, Mori R
    • Organizer
      The 35th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2012-09-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Inhibitory effects of tempol, a free radical scavenger, on long-lasting widespread mechanical hyper- algesia in a rat model of cast immobilization2012

    • Author(s)
      Ohmichi Y, Ohmichi M, Sakurai H, Nakano T, Asamoto K, Ushida T, Sato J
    • Organizer
      14th World Congress on Pain
    • Place of Presentation
      Milano
    • Year and Date
      2012-08-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Inhibitory effects of minocycline, an inhibitor of spinal microglial activation, on widespread mech- anical hyperalgesia in a rat model of cast immobilization2012

    • Author(s)
      Ohmichi M, Ohmichi Y, Nakano T, Asamoto K, Ushida T, Ohichi H, Sato J
    • Organizer
      14th World Congress on Pain
    • Place of Presentation
      Milano
    • Year and Date
      2012-08-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Tempolはギプス固定後慢性痛ラットの持続性の広範囲機械痛覚増強と脊髄アストロサイトの活性化を抑制する2012

    • Author(s)
      大道裕介, 大道美香, 櫻井博紀, 浅元憲, 牛田享宏, 佐藤純
    • Organizer
      第34回日本疼痛学会
    • Place of Presentation
      熊本
    • Year and Date
      2012-07-19
    • Related Report
      2013 Final Research Report
  • [Presentation] トレッドミル運動及びストレッチはラット後肢ギプス固定後の機械的痛覚過敏を軽減した2012

    • Author(s)
      森本温子, Winaga Handriadi, 大道裕介, 牛田享宏, 岡田忠, 佐藤純
    • Organizer
      第34回日本疼痛学会
    • Place of Presentation
      熊本
    • Year and Date
      2012-07-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetertrazole-treated mice by convert- ing pro-BDNF to mature BDNF in the hippo- campus2012

    • Author(s)
      Mizoguchi H, Sato J, Sawada M, Nabeshima T, Yamada K
    • Organizer
      The 8th FENS Forum of Neuro- science
    • Place of Presentation
      Barcelona
    • Year and Date
      2012-07-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 痛みと自律神経系2012

    • Author(s)
      佐藤純
    • Organizer
      第65回日本自律神経学会総会,シンポジウム4 しびれ・痛みと自律神経障害
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Increase in cold sensitivity of heart rate in a mouse model of anxiety/depression.2012

    • Author(s)
      SATO Jun, MIZUTANI Yuki, MIZOGUCHI Hiroyuki, KODAMA Koji, ITOH Mariko, MORI Rarami
    • Organizer
      The 35th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetertrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.2012

    • Author(s)
      MIZOGUCHI Hiroyuki, SATO Jun, SAWADA Makoto, NABESHIMA Toshitaka, YAMADA Kiyorumi
    • Organizer
      The 8th FENS Forum of Neuroscience
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] トレッドミル運動およびストレッチはラット後肢ギプス固定後の機械的痛覚過敏を軽減した.2012

    • Author(s)
      森本温子, WINAGA Handriadi,大道裕介,牛田享宏,岡田忠,佐藤純
    • Organizer
      第34回日本疼痛学会
    • Place of Presentation
      熊本
    • Related Report
      2012 Research-status Report
  • [Presentation] Tempolはギプス固定後慢性痛ラットの持続性の広範囲機械痛覚増強と脊髄アストロサイトの活性化を抑制する.2012

    • Author(s)
      大道裕介, 大道美香, 櫻井博紀,浅元 憲,牛田享宏,佐藤純
    • Organizer
      第34回日本疼痛学会
    • Place of Presentation
      熊本
    • Related Report
      2012 Research-status Report
  • [Presentation] Inhibitory effects of minocycline, an inhibitor of spinal microglial activation, on widespread mechanical hyperalgesia in a rat model of cast immobilization.2012

    • Author(s)
      OHMICHI Mika, OHMICHI Yusuke, NAKANO Takashi, ASAMOTO Ken, USHIDA Takahiro, OHISHI Hitoshi, SATO Jun
    • Organizer
      14th World Congress on Pain
    • Place of Presentation
      Milano, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] Inhibitory effects of tempol, a free radical scavenger, on long-lasting widespread mechanical hyperalgesia in a rat model of cast immobilization.2012

    • Author(s)
      OHMICHI Yusuke, OHMICHI Mika, SAKURAI Hiroki , NAKANO Takashi, ASAMOTO Ken, USHIDA Takahiro, SATO Jun
    • Organizer
      14th World Congress on Pain
    • Place of Presentation
      Milano, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] 姿勢・運動パターンによる運動器慢性疼痛患者評価の試み2012

    • Author(s)
      櫻井博紀, 井上雅之, 森本温子, 大道裕介, 井上真輔, 池本竜則, 新井健一, 西原真理, 佐藤 純, 牛田享宏
    • Organizer
      第5回日本運動器疼痛学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] ストレスと痛み2011

    • Author(s)
      佐藤純
    • Organizer
      第8回宮﨑ペインカンファランス
    • Place of Presentation
      宮﨑
    • Year and Date
      2011-11-15
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 気圧低下環境におけるラット片頭痛行動検出の試み2011

    • Author(s)
      舟久保恵美, 佐藤純, 水村和枝
    • Organizer
      第50回日本生気象学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-05
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 天気と病気2011

    • Author(s)
      佐藤純
    • Organizer
      第4回環境学公開講演会名古屋大学大学院環境学研究科しんきん環境事業イノベーション寄附講座
    • Place of Presentation
      瀬戸
    • Year and Date
      2011-09-27
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 自律神経と疼痛2011

    • Author(s)
      佐藤純
    • Organizer
      神戸大学がんプロフェッショナル養成プラン講義
    • Place of Presentation
      神戸
    • Year and Date
      2011-09-08
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 慢性痛のトランスレーショナル・リサーチ-天気痛のメカニズムを動物実験で探る-2011

    • Author(s)
      佐藤純
    • Organizer
      ヒューマンサイエンス振興財団将来動向調査勉強会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-01
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] ストレスと痛み,天候と痛み2011

    • Author(s)
      佐藤純
    • Organizer
      日本ペインクリニック学会第45回大会
    • Place of Presentation
      松山
    • Year and Date
      2011-07-23
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] ラット後肢ギプス固定後の機械的痛覚過敏に対するトレッドミル運動効果についての検討2011

    • Author(s)
      森本温子, 大道裕介, 櫻井博紀, 吉本隆彦, 大道美香, 橋本辰幸, 牛田享宏, 岡田忠, 熊澤孝朗, 佐藤純
    • Place of Presentation
      松山
    • Year and Date
      2011-07-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 運動器慢性痛患者への環境温曝露試験—温度感覚異常を訴える症例の検討—2011

    • Author(s)
      櫻井博紀, 佐藤純, 吉本隆彦, 大道裕介, 森本温子, 大道美香, 西原真理, 新井健一, 牛田享宏
    • Organizer
      第46回日本理学療法学術大会
    • Place of Presentation
      宮﨑
    • Year and Date
      2011-05-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 痛みと天気と自律神経2011

    • Author(s)
      佐藤純
    • Organizer
      第2回兵庫県痛みを考える会
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-28
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 痛みと天気と自律神経2011

    • Author(s)
      佐藤 純
    • Organizer
      第2回兵庫県痛みを考える会(招待講演)
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] ストレスと痛み, 天候と痛み2011

    • Author(s)
      佐藤 純
    • Organizer
      日本ペインクリニック学会第45回大会(招待講演)
    • Place of Presentation
      松山
    • Related Report
      2011 Research-status Report
  • [Presentation] 慢性痛のトランスレーショナル・リサーチ ー天気痛のメカニズムを動物実験で探るー2011

    • Author(s)
      佐藤 純
    • Organizer
      ヒューマンサイエンス振興財団将来動向調査勉強会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 自律神経と疼痛2011

    • Author(s)
      佐藤 純
    • Organizer
      神戸大学 がんプロフェッショナル養成プラン講義(招待講演)
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 天気と病気2011

    • Author(s)
      佐藤 純
    • Organizer
      第四回環境学公開講演会 名古屋大学大学院環境学研究科しんきん環境事業イノベーション寄附講座(招待講演)
    • Place of Presentation
      瀬戸
    • Related Report
      2011 Research-status Report
  • [Presentation] ストレスと痛み2011

    • Author(s)
      佐藤 純
    • Organizer
      第8回宮崎ペインカンファランス(招待講演)
    • Place of Presentation
      宮崎
    • Related Report
      2011 Research-status Report
  • [Presentation] 運動器慢性痛患者への環境温曝露試験 ー温度感覚異常を訴える症例の検討ー2011

    • Author(s)
      櫻井博紀, 佐藤 純, 吉本隆彦, 大道裕介, 森本温子, 大道美香, 西原真里理, 新井健一, 牛田享宏
    • Organizer
      第46回日本理学療法学術大会
    • Place of Presentation
      宮崎
    • Related Report
      2011 Research-status Report
  • [Presentation] ラット後肢ギプス固定後の機械的痛覚過敏に対するトレッドミル運動効果についての検討2011

    • Author(s)
      森本温子, 大道裕介, 櫻井博紀, 吉本隆彦, 大道美香, 橋本辰幸, 牛田享宏, 岡田 忠, 熊澤孝朗, 佐藤 純
    • Organizer
      第33回日本疼痛学会
    • Place of Presentation
      松山
    • Related Report
      2011 Research-status Report
  • [Book] 天気と病気、未来へつなぐたからもの持続可能な社会を考える2012

    • Author(s)
      佐藤純
    • Total Pages
      267
    • Publisher
      風媒社出版
    • Related Report
      2013 Final Research Report
  • [Book] 未来へつなぐたからもの 持続可能な社会を考える2012

    • Author(s)
      佐藤純
    • Total Pages
      267
    • Publisher
      天気と病気
    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi