Research on racial difference of sleep disordered breathing, and development of the Japanese version of sleep disorder evaluation tool

• Project/Area Number: 23590796
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Tenri Health Care University (2012-2013); Ehime University (2011)
• Principal Investigator: SAKURAI Susumu 天理医療大学, 医療学部, 教授 (50375515)
• Co-Investigator(Kenkyū-buntansha): TANIGAWA Takeshi 愛媛大学, 医学(系)研究科, 教授 (80227214) ; OKA Yasunori 愛媛大学, 医学部附属病院, 准教授 (60419025) ; NAKATA Akinori 産業医科大学, 産業保健学部, 教授 (80333384)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 国際研究者交流 / 米国 / ハワイ / 睡眠調査 / 日本人 / 日系人 / 追跡調査 / 睡眠時無呼吸症候群 / 睡眠問診票 / 疫学調査 / パルスオキシメータ / フロー検査 / 早朝血圧

Research Abstract

To evaluated the racial difference of sleep disordered breathing, sleep apnea syndrome screening test, blood-pressure measurement, and the Japanese version Harvard University sleep questionnaire were performed among 29 Japanese (31% males, mean age 70) living in Honolulu.
An average 3%ODI values were 20% for males and 13% for females. Significant associations were found between hyoid-mental distance and severity of sleep disordered breathing as well as heart rate before and after sleeping.
Those who were suspected to suffer from SAS were patients under treatment or naysayers. A major reason for refusing treatment was a high medical costs and examination fees.

Research Products

• [Journal Article] Nocturnal intermittent hypoxia as an associated risk factor for microalbuminuria in Japanese patients with type 2 diabetes mellitus (2013)
  • Author(s): Furukawa S, Saito I, Yamamoto S, Miyake T, Ueda T, Niiya T, Torisu M, Kumagi T, Sakai T, Minami H, Miyaoka H, Sakurai S, Matsuura B, Onji M, Tanigawa T
  • Journal Title: Eur J Endocrinol Pages: 239-46
  • Peer Reviewed
• [Journal Article] Organizational factors associated with work-related sleep problems in a nationally representative sample of Korean workers (2013)
  • Author(s): Park JB, Nakata A, Swanson NG, Chun HK
  • Journal Title: Int Arch Occup Environ Health Volume: 169(2)
  • Peer Reviewed
• [Journal Article] Nocturnal intermittent hypoxia as an associated risk factor for microalbuminuria in Japanese patients with type 2 diabetes mellitus. (2013)
  • Author(s): Furukawa S, Saito I, Yamamoto S, Miyake T, Ueda T, Niiya T, Torisu M, Kumagi T, Sakai T, Minami H, Miyaoka H, Sakurai S, Matsuura B, Onji M, Tanigawa T.
  • Journal Title: Eur J Endocrinol. Volume: 169 Pages: 239-46
  • Peer Reviewed
• [Journal Article] Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage : The J-SHIP Toon Health Study (2012)
  • Author(s): Tabara Y, Igase M, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Okada Y, Hitsumoto S, Onuma H, Nagai T, Takata Y, Uetani E, Takita R, Kido T, Ochi N, Osawa H, Tanigawa T, Miki T
  • Journal Title: Clin Hemorheol Microcirc Pages: 211-222
  • NAID: 120005366009
  • Peer Reviewed
• [Journal Article] Self-reported snoring frequency and incidence of cardiovascular disease : the Circulatory Risk in Communities Study (CIRCS) (2012)
  • Author(s): Nagayoshi M, Tanigawa T, Yamagishi K, Sakurai S, Kitamura A, Kiyama M, Okada T,Maeda K, Ohira T, Imano H, Sato S, Iso H; CIRCS Investigators
  • Journal Title: J Epidemiol Volume: 22(4) Pages: 295-301
  • NAID: 10030784066
  • Peer Reviewed
• [Journal Article] 糖尿病における睡眠呼吸障害(sleep‐disorder breathing; SDB)と細小血管障害に関する多施設共同横断調査(道後STUDY) (2012)
  • Author(s): 古川慎哉, 三宅映巳, 上田晃久, 山本晋, 宮岡省蔵, 新谷哲司, 南尚佳, 酒井武則, 櫻井進, 宮岡弘明, 斉藤功, 松浦文三, 谷川武, 恩地森一
  • Journal Title: 糖尿病誌 Volume: 55 Pages: 289-289
  • Peer Reviewed
• [Journal Article] 児童青年期の睡眠の問題:学齢による眠気と睡眠時間との関連 (2012)
  • Author(s): 堀内史枝, 岡靖哲, 淡野桜子, 高田律美, 川崎由理, 櫻井進, 斉藤功, 谷川武, 上野修一
  • Journal Title: 不眠研究 Pages: 101-106
  • Peer Reviewed
• [Journal Article] 身体活動と睡眠呼吸障害との関連に関する横断的研究:東温スタディ (2012)
  • Author(s): 尾崎智樹, 江口依里, 斉藤功, 丸山広達, 櫻井進, 森浩実, 吉村加奈, 淡野桜子, 谷川武
  • Journal Title: 四国公衆衛生学会誌 Volume: 58 Pages: 62-63
  • Peer Reviewed
• [Journal Article] 身体活動と睡眠呼吸障害との関連に関する横断的研究:東温スタディ (2012)
  • Author(s): 古川慎哉, 新谷哲司, 南尚佳, 酒井武則, 櫻井進, 宮岡弘明, 斉藤功, 松浦文三, 谷川武, 恩地森一
  • Journal Title: 糖尿病誌 Volume: 55 Pages: 353-353
  • Peer Reviewed
• [Journal Article] Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: The J-SHIP Toon Health Study (2012)
  • Author(s): Tabara Y, Igase M, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Okada Y, Hitsumoto S, Onuma H, Nagai T, Takata Y, Uetani E, Takita R, Kido T, Ochi N, Osawa H, Tanigawa T, Miki T
  • Journal Title: Clin Hemorheol Microcirc Volume: in press Issue: 3 Pages: 297-311
  • DOI: 10.3233/ch-2012-1634
  • NAID: 120005366009
  • Peer Reviewed
• [Journal Article] Self-reported snoring frequency and incidence of cardiovascular disease: the Circulatory Risk in Communities Study (CIRCS). (2012)
  • Author(s): Nagayoshi M
  • Journal Title: J Epidemiol. Volume: 22 Pages: 295-301
  • Peer Reviewed
• [Journal Article] Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance : the Toon Health Study (2011)
  • Author(s): Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T
  • Journal Title: J Hypertens Volume: 29(10) Pages: 1948-1954
  • Peer Reviewed
• [Journal Article] Risk factors for snoring among Japanese men and women : a community-based cross-sectional study (2011)
  • Author(s): Nagayoshi M, Yamagishi K, Tanigawa T, Sakurai S, Kitamura A, Kiyama M, Imano H, Ohira T, Sato S, Sankai T, Iso H; for the CIRCS Investigators
  • Journal Title: Sleep Breath Volume: 15(1) Pages: 63-69
  • Peer Reviewed
• [Journal Article] Associations between alcohol consumption and sleep-disordered breathing among Japanese women (2011)
  • Author(s): Cui R, Tanigawa T, Sakurai S, Yamagishi K, Muraki I, Imano H, Ohira T, Kiyama M, Kitamura A, Ishikawa Y, Iso H; CIRCS Investigators
  • Journal Title: Respir Med Volume: 105(5) Pages: 796-800
  • NAID: 120007130888
  • Peer Reviewed
• [Journal Article] Relationship between sleep-disordered breathing and perinatal outcome in pregnant women (2011)
  • Author(s): Miyagawa S, Emori Y, Kawano A, Sakurai S, Tanigawa T
  • Journal Title: J Jpn Acad Midwif Volume: 25(1) Pages: 5-12
  • NAID: 130004505907
  • Peer Reviewed
• [Journal Article] Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance: the Toon Health Study. (2011)
  • Author(s): Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T.
  • Journal Title: J Hypertens Volume: 29 Pages: 1948-1954
  • Peer Reviewed
• [Journal Article] Chronic kidney disease and drinking status in relation to risks of stroke and its subtypes: the Circulatory Risk in Communities Study (CIRCS). (2011)
  • Author(s): Shimizu Y, Maeda K, Imano H, Ohira T, Kitamura A, Kiyama M, Okada T, Ishikawa Y, Shimamoto T, Yamagishi K, Tanigawa T, Iso H.
  • Journal Title: Stroke Volume: 42 Pages: 2531-2537
  • Peer Reviewed
• [Journal Article] C-reactive protein levels and risk of stroke and its subtype in Japanese: The Circulatory Risk in Communities Study(CIRCS). (2011)
  • Author(s): Chei CL, Yamagishi K, Kitamura A, Kiyama M, Imano H, Ohira T, Cui R, Tanigawa T, Sankai T, Ishikawa Y, Sato S, Iso H.
  • Journal Title: Atherosclerosis Volume: 217 Pages: 187-193
  • Peer Reviewed
• [Journal Article] Associations between alcohol consumption and sleep-disordered breathing among Japanese women. (2011)
  • Author(s): Cui R, Tanigawa T, Sakurai S, Yamagishi K, Muraki I, Imano H, Ohira T, Kiyama M, Kitamura A, Ishikawa Y, Iso H; CIRCS Investigators.
  • Journal Title: Atherosclerosis Volume: 105 Pages: 796-800
  • NAID: 120007130888
  • Peer Reviewed
• [Journal Article] Relationship between sleep-disordered breathing and perinatal outcome in pregnant women. (2011)
  • Author(s): Miyagawa S, Emori Y, Kawano A, Sakurai S, Tanigawa T.
  • Journal Title: J Jpn Acad Midwif Volume: 25 Pages: 5-12
  • NAID: 130004505907
  • Peer Reviewed
• [Presentation] Nocturnal intermittent hypoxia and cardiovascular risk factors in community-dwelling Japanese: The Circulatory Risk in Communities Study (CIRCS). (2011)
  • Author(s): Tanigawa T, Muraki I, Yamagishi K, Sakurai S, Ohira T, Imano H, Kitamura A, Kiyama M, Sato S, Iso H.
  • Organizer: World congress of Epidemiology
  • Place of Presentation: Edinburgh, England.
• [Book] 睡眠呼吸障害と交通安全.トラック奈良.234 (2013)
  • Author(s): 谷川武, 蓮花一己, 木村弘, 金子弘史, 野村卓司, 田中照浩, 櫻井進
  • Publisher: (奈良)
• [Book] 睡眠呼吸障害と交通安全. IATTSブックレット.国際交通安全学会誌.5 (2013)
  • Author(s): 谷川武, 蓮花一己, 木村弘, 岩貞るみこ, 櫻井進
  • Publisher: (東京)
• [Book] 睡眠呼吸障害健診の受診の仕方.睡眠呼吸障害と交通安全. IATTSブックレット.国際交通安全学会誌.5 (2013)
  • Author(s): 櫻井進
  • Publisher: (東京)
• [Book] 睡眠時無呼吸症候群スクリーニング検査.睡眠呼吸障害のUp to date. Medical Science Digest 39(2) (2013)
  • Author(s): 谷川武, 櫻井進、三浦仁
• [Book] 睡眠呼吸障害と交通安全 (2013)
  • Author(s): 谷川武、蓮花一己、木村弘、金子弘史、野村卓司、田中照浩、櫻井進．
  • Total Pages: 6
  • Publisher: トラック奈良
• [Book] IATTS ﾌﾞｯｸﾚｯﾄ (2013)
  • Author(s): 谷川武、蓮花一己、木村弘、岩貞るみこ、櫻井進
  • Total Pages: 29
  • Publisher: 国際交通安全学会誌
• [Book] IATTS ﾌﾞｯｸﾚｯﾄ (2013)
  • Author(s): 櫻井進
  • Total Pages: 9
  • Publisher: 国際交通安全学会誌
• [Book] 睡眠呼吸障害のUp to date (2013)
  • Author(s): 谷川武、櫻井進、三浦仁
  • Total Pages: 2
  • Publisher: Medical Science Digest
• [Book] 睡眠時無呼吸症候群スクリーニング検査．睡眠呼吸障害のUp to date. (2013)
  • Author(s): 谷川武、櫻井進、三浦仁
  • Total Pages: 2
  • Publisher: Medical Science Digest
• [Book] SAS健診の受診の仕方.トラック運転者の睡眠障害と健康問題.トラック奈良 (2012)
  • Author(s): 谷川武, 蓮花一己, 岩貞るみこ, 木村弘, 櫻井進
  • Publisher: (奈良)
• [Book] SAS健診の受診の仕方. トラック運転者の睡眠障害と健康問題 (2012)
  • Author(s): 3.谷川武、蓮花一己、岩貞るみこ、木村 弘、櫻井進
  • Total Pages: 5
  • Publisher: トラック奈良
• [Book] 知っておこう！睡眠時無呼吸症候群 （ＳＡＳ） Ｑ＆Ａ (2011)
  • Author(s): 谷川武
  • Total Pages: 45
  • Publisher: 株式会社大成出版
• [Remarks]
  • URL: http://www.tenriyorozu-u.ac.jp/c/clinical/contents/teacher
• [Remarks] 天理医療大学教員紹介
  • URL: http://www.tenriyorozu-u.ac.jp/c/clinical/contents/teacher
• [Remarks] 天理医療大学臨床検査学科教員ページ
  • URL: http://www.tenriyorozu-u.ac.jp/c/clinical/contents/teacher