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Relationship between alcoholic liver disorders and sudden death

Research Project

Project/Area Number 23590850
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionYamaguchi University

Principal Investigator

FUJIMIYA Tatsuya  山口大学, 医学(系)研究科(研究院), 教授 (50219044)

Co-Investigator(Kenkyū-buntansha) LIU Jinyao  山口大学, 大学院医学系研究科, 講師 (60379956)
HAKUCHO Ayako  山口大学, 大学院医学系研究科, 助教 (90593301)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsアルコール / 肝障害 / 脂肪肝 / 突然死 / 大酒家 / 心筋症 / 法医学 / アルコール医学 / 骨髄由来細胞
Outline of Final Research Achievements

We studied the relationship between alcoholic liver disorders and sudden death. Rats and Mouse were treated with Liber diet which includes alcohol or sugar of the same calories for 6 weeks. Then animals were divided to the control group, sustained alcohol treated group and alcohol withdrawal group for 1day to 3 weeks. The liver and heart were pathologically examined. As a result, the sudden death occurred in the alcohol withdrawal group for 1 day. The liver revealed fat deposits and myofibroblast proliferation. The heart revealed slight fibrosis between myocytes.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results)

  • [Journal Article] 高血圧症がアルコール性肝障害に及ぼす影響-SHRラット慢性飲酒モデルによる基礎的検討-2014

    • Author(s)
      白鳥彩子、劉金耀、劉旭、藤宮龍也
    • Journal Title

      アルコールと医学生物学

      Volume: 33 Pages: 95-98

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高血圧自然発症ラットにおける慢性アルコール投与による肝障害増悪への影響2013

    • Author(s)
      白鳥彩子,劉 金耀,堀口直也,劉 旭,藤宮龍也
    • Journal Title

      日本アルコール・薬物医学会雑誌

      Volume: 48 Pages: 216-222

    • NAID

      10031183043

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] アルコール性脂肪肝ラットにおける交感神経活性化を介する肝臓星細胞の活性化2013

    • Author(s)
      岡村菜奈子,劉 金耀,高瀬 泉,白鳥彩子,劉 旭,藤宮龍也
    • Journal Title

      アルコールと医学生物学

      Volume: 32 Pages: 51-55

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] アルコール性肝障害における酸化ストレスと交感神経活性化との関連2012

    • Author(s)
      白鳥彩子
    • Journal Title

      アルコールと医学生物学

      Volume: 31 Pages: 113-115

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] アルコール心臓性突然死における交感神経活性化と心筋細胞ギャップ結合リモデリングとの関連2012

    • Author(s)
      劉金耀
    • Journal Title

      アルコールと医学生物学

      Volume: 31 Pages: 54-56

    • Related Report
      2012 Research-status Report
    • Peer Reviewed

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Published: 2011-08-05   Modified: 2019-07-29  

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