Detection of novel actions of kampo medicines for lipid metabolism by lipidomic analysis
| Project/Area Number |
23590873
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General internal medicine (including Psychosomatic medicine)
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
SHIRO Watanabe 富山大学, 和漢医薬学総合研究所, 准教授 (00222406)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUNEYAMA Koichi 富山大学, 大学院医学薬学研究部(医学), 准教授 (10293341)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 胆汁酸 / トリグリセリド / 一価不飽和脂肪酸 / ステアリン酸CoA不飽和化酵素1 / ステアリン酸CoA不飽和化酵素１ / コレステロールエステル / トランスアミナーゼ / コール酸 / 肝傷害 / エイコサペンタエン酸 / リポプロテインリパーゼ |
|---|
| Research Abstract |
The administration of Boiogito (BOT) was shown to ameliorate liver injury in the mice fed a cholate (CA)-supplemenetd diet. This effect was associated with a partial restoration of the reduction in liver triglyceride (TG) content. The levels of gene and protein of stearoyl-CoA desaturase-1 (SCD1) were lowered in the mice fed the CA-supplemented diet, which were elevated by BOT administration. These results suggest that the amelioration of CA-induced liver injury by BOT administration may be due to the restoration of reduced synthesis of liver TG through the facilitation of desaturation of saturated fatty acids, which is required in the efficient TG synthesis in liver. Alternatively, the reduction in liver TG levels might be a consequence of the amelioration of CA-induced liver injury by BOT administration. Thus, our lipidomic analysis revealed a novel mechanism involved in the modulation of lipid metabolism by a kampo medicine during bile acid-induced steatohepatitis in the mice.
|
Report
(4 results)
Research Products
(34 results)
-
-
-
-
-
-
-
-
-
-
[Journal Article] A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching LC/MS/MS.2012
Author(s)
Watanabe K, Ishikawa C, Kuwahara H, Sato K, Komuro S, Nakagawa T, Nomura N, Watanabe S, Yabuki M.
-
Journal Title
Anal. Bioanal. Chem.
Volume: 402
Pages: 2033-2042
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Presentation] 豚胆の脂質低下作用2012
Author(s)
渡辺志朗、李峰、米山惇志、湖間戸俊輔
Organizer
第29回和漢医薬学会学術大会
Place of Presentation
東京
Year and Date
2012-09-12
Related Report
-
-
-
[Presentation] A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching-LC/MS/MS2012
Author(s)
渡辺健一,石川千裕,桑原弘,佐藤公彦,小室勢津子,中川徹也,野村成章,矢吹昌司,渡辺志朗
Organizer
日本薬物動態学会第27回年会
Place of Presentation
東京
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
