| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We analyzed AID expression in EBV-associated Gastric cancers by immunohistochemistry, however,specific reaction by the antibody could not be detected in the paraffin-embedded tissue section. High-density DNA oligonucleotide arrays was performed in mononuclear cells of the patients with EBV-associated Gastric cancers. Copy number variation which specifically occured in the patients will be identified from big data. The association of DNA methylation in the development of EBV-associated Gastric cancers was also examined. We found several tumor suppressor genes whose promoter regions were specificcly methylated in EBV-associated Gastric cancers.Inactivation of these genes may suppress their function as tumor suppressor genes or tumor-associated antigen to develop and maintain EBVaGCs.
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