Inhibitory role of Gas6-mediated innate immunity in intestinal tumorigenesis
Project/Area Number |
23590937
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Kyoto University |
Principal Investigator |
SENO Hiroshi 京都大学, 医学(系)研究科(研究院), 講師 (90335266)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 大腸 / 腸炎 / 腫瘍 / マウス / マクロファージ / 癌 / 炎症 / 大腸癌 / 自然免疫 |
Research Abstract |
Commensal microbiota affects on the maintenance of systemic homeostasis by the interaction with innate immune cells. Growth arrest specific gene 6 (Gas6) regulates innate immune responses through Stat1/3 signaling. Genetic deletion of Gas6 ameliorated inflammation and tumor formation in the mouse intestines caused by AOM/DSS treatment or insertion of Apc gene mutation. Gas6 knockout mice with intestinal tumors showed significantly shorter survival compared to wild type littermates. As well, colorectal cancer patients with lower Gas6 expression showed shorter survival. These data suggested the importance of innate immunity in the treatment of colorectal cancer.
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Report
(4 results)
Research Products
(18 results)