TWEAK is involved in DNA damage in intestinal epithelial cells
Project/Area Number |
23590955
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Research Institute, International Medical Center of Japan |
Principal Investigator |
DOHI Taeko 独立行政法人国立国際医療研究センター, 研究所 肝炎・免疫研究センター 消化器疾患研究部, 部長 (60250221)
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Co-Investigator(Renkei-kenkyūsha) |
KAWAMURA I Yuki 国立国際医療研究センター研究所肝炎・免疫研究センター, 消化器疾患研究部, 病態生理研究研究室長・室長 (10392391)
ISHIZAKA Yukihito 国立国際医療研究センター研究所, 副所長 (30281687)
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Research Collaborator |
OTSUBO Takeshi 国立国際医療研究センター研究所肝炎・免疫研究センター, 消化器疾患研究部, 特任研究員 (00623034)
KAWASHIMA Rei 北里大学, 医療衛生学部, 助教 (70392389)
BURKLY Linda C. Distinguished Investigator, Departments of Immunobiology and Drug Discovery, Biogen Idec
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 消化管上皮細胞 / TWEAK / Fn14 / DNA傷害 / 炎症 / 消化管炎症 / TNFSF / レトロトランスポジション / TNFSP |
Research Abstract |
TNF-like weak inducer of apoptosis (TWEAK) is a member of TNF superfamily (TNFSF). Its receptor FGF-inducible molecule-14 (Fn14) has been identified. DNA damage is induced by gamma-irradiation and anti-cancer drugs. Gastrointestinal mucosal damage is one of the most significant side-effects of these treatments, which limits the dose of treatment. In this study, we found that TWEAK/Fn14 pathway is significantly involved in the DNA damage of intestinal mucosa that induced by gamma-irradiation and some type of anti-cancer drugs. Particularly, TWEAK enhances death signal mediated by Tumor necrosis factor (TNF)-alfa. results suggest the possible application of TWEAK inhibitors to prevent mucosal damage in cancer therapy.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Retrotransposition of long interspersed element-1 by viral protein R of human immunodeficiency virus type-12013
Author(s)
Kenta Iijima, Noriyuki Okudaira, Masato Tamura, Akihiro Doi, Yoshikazu Saito, Mari Shimura, Motohito Goto, Akihiro Matsunaga, Yuki Kawamura, Takeshi Otsubo, Taeko Dohi, Shigeki Hoshino, Shigeyuki Kano, Shotaro Hagiwara, Junko Tanuma, Hiroyuki Gatanaga, Masanori Baba, Taku Iguchi, Motoko Yanagita, Shin-ichi Oka Tadashi Okamura and Yukihito Ishizaka
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Journal Title
Retrovirology
Volume: 10
Issue: 1
Pages: 83-83
DOI
Related Report
Peer Reviewed
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[Journal Article] TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice2013
Author(s)
Son A, Oshio T, Kawamura YI, Hagiwara T, Yamazaki M, Inagaki-Ohara K, Okada T, Wu P, Iseki M, Takaki S, Burkly LC, Dohi T
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Journal Title
Mucosal Immunology
Volume: 6
Issue: 6
Pages: 1131-1142
DOI
Related Report
Peer Reviewed
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[Journal Article] Colonic epithelial cells express specific ligands for mucosal macrophage immunosuppressive receptors, siglec-7 and-92012
Author(s)
Miyazaki, K., Sakuma, K., Kawamura, Y. I., Izawa, M., Ohmori, K., Mitsuki, M., Yamaji, T., Hashimoto, Y., Suzuki, A., Saito, Y., Dohi, T., and Kannagi, R.
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Journal Title
J. Immunol
Volume: 188
Issue: 9
Pages: 4690-4700
DOI
Related Report
Peer Reviewed
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[Journal Article] Interleukin-13 Damages Intestinal Mucosa via TWEAK and Fn14 in Mice - a Pathway Associated with Ulcerative Colitis2011
Author(s)
Kawashima R, Kawamura YI, Oshio T, Son A, Yamazaki M, Hagiwara T, Okada T, Inagaki-Ohara K, Wu P, Szak S, Kawamura YJ, Konishi F, Miyake O, Yano H, Saito Y, Burkly LC, Dohi T
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Journal Title
Gastroenterology
Volume: 141
Issue: 6
Pages: 2119-2129
DOI
Related Report
Peer Reviewed
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[Presentation] TWEAK/Fn14 pathway mediates IL-13 induced intestinal epithelial cell death2012
Author(s)
Kawashima R, Kawamura YI, Oshio T, Hagiwara T, Okada T, Inagaki–Ohara K, Wu P, Szak S, Kawamura YJ, Konishi F, Miyake O, Yano H, Ichikawa T, Saito Y, Burkly LC And Dohi T
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Year and Date
2012-12-05
Related Report
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[Presentation] IL-13 induces TWEAK-dependent activation of TNF- and intestinal epithelial cell damage –a pathway associated with ulcerative colitis2012
Author(s)
T Dohi, R Kawashima, YI Kawamura, T Oshio, M Yamazaki, T Hagiwara, T Okada, P Wu, S Szak, YJ Kawamura, F Konishi, O Miyake, H Yano, Y Saito, L. C. Burkly
Organizer
Digestive Disease Week, 2012
Place of Presentation
San Diego, U. S. A(Abstract in; Gastroenterology, Volume 142, Issue 5, Supplement 1, May 2012, PagesS-346-S-347)
Year and Date
2012-05-19
Related Report
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[Presentation] Interleukin-13 links to TWEAK/Fn14 pathway in intestinal epithelial cell injury2011
Author(s)
Kawashima R, Kawamura YI, Oshio T, Son A, Yamazaki M, Hagiwara T, Okada T, Wu P, Szak S, Kawamura YJ, Konishi F, Miyake O, Yano H, Saito Y, Burkly LC, Dohi T
Organizer
TNF 2011
Place of Presentation
Awajishima, Hyogo
Year and Date
2011-05-16
Related Report
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[Presentation] Interleukin-13 links to TWEAK/Fn14 pathway in intestinal epithelial cell injury2011
Author(s)
R Kawashima, YI Kawamura1, T Oshio, A Son, M Yamazaki, T Hagiwara, T Okada, P Wu, S Szak, YJ Kawamura, F Konishi, O Miyake, H Yano, Y Saito, LC Burkly, T Dohi.
Organizer
TNF 2011
Place of Presentation
Hyogo, Japan
Related Report
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[Presentation] IL-13 induces TWEAK-dependent activation of TNF-α and intestinal epithelial cell damage –a pathway associated with ulcerative colitis.
Author(s)
T Dohi, R Kawashima, YI Kawamura, T Oshio, M Yamazaki, T Hagiwara, T Okada, P Wu, S Szak, YJ Kawamura, F Konishi, O Miyake, H Yano, Y Saito, L. C. Burkly
Organizer
Digestive Disease Week, 2012
Place of Presentation
San Diego, U. S. A
Related Report
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[Presentation] TWEAK/Fn14 pathway mediates IL-13 induced intestinal epithelial cell death.
Author(s)
Kawashima R, Kawamura YI, Oshio T, Hagiwara T, Okada T, Inagaki–Ohara K, Wu P, Szak S, Kawamura YJ, Konishi F, Miyake O, Yano H, Ichikawa T, Saito Y, Burkly LC And Dohi T
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
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