| Project/Area Number |
23590986
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Ryuuichi 奈良県立医科大学, 医学部, 助教 (30423908)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肝硬変 / 肝癌 / 血管新生 / 慢性肝疾患 / カクテル療法 |
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| Research Abstract |
During the period of this grant, we revealed many new findings about the usefulness of the combined cocktail therapy of clinical available agents in patients with chronic liver diseases. Even at clinical comparable low doses of these agents, we observed significant inhibitory effects on the liver fibrosis development, hepatocarcinogenesis, and the growth of hepatocellular carcinoma (HCC). We mainly focused on renin-angiotensin system (RAS) in the chronic liver diseases, and found that angiotensin-II (AT-II), aldosterone (Ald), and renin play important roles in the respective processes. Several different combination cocktail treatments also exerted marked inhibitory effects even at clinically comparable low doses. Furthermore, not only in the animal studies, but also we revealed clinical usefulness with these agents.
Collectively, our studies with this grant could contribute to the improvement of prognosis in patients with chronic liver diseases.
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