| Project/Area Number |
23591032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
IZUMI Daisuke 新潟大学, 医歯学総合病院, 特任助教 (30529699)
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| Co-Investigator(Kenkyū-buntansha) |
CHINUSHI Masaomi 新潟大学, 医歯学系, 准教授 (40303151)
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| Co-Investigator(Renkei-kenkyūsha) |
FURUSHIMA Hiroshi 新潟大学, 医歯学総合病院, 助教 (10377161)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | QT延長 / T波 / 不整脈 / 再分極 / 多形性心室頻拍 / 多型性心室頻拍 |
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| Research Abstract |
Fatal ventricular tachyarrhythmias often originate from enlargement of ventricular transmural dispersion of repolarization (TDR). Using canine model which showed spacial heterogeneous distribution of ventricular repolarization, we studied the relationship between the interval of the peak-to-end of the T wave (Tp-e) in ECG and the 3-dimensional repolarization heterogeneity. Tp-e in the limb leads expresses total distribution of repolarization in the left ventricle (LV). The proportion of variance of TDR in each LV region for Tp-e on V2-4 were higher in the anterior rather than in the lateral region, while those on V5-6 were higher in the lateral or midventricular/apical region rather than in the anterior or basal region. The precordial Tp-e seemed to express a certain degree of TDR at near and vertical ventricular wall. These results elucidated the electrophysiological background of the T wave and showed the alternative method of the discrimination of the fatal arrhythmic risk.
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