Development of new treatments for cardiac remodeling after myocardial infarction using heparin cofactor II

• Project/Area Number: 23591046
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: IWASE Takashi 徳島大学, 大学病院, 助教 (10403718)
• Co-Investigator(Kenkyū-buntansha): SATA Masataka 徳島大学, ヘルスバイオサイエンス研究部, 教授 (80345214) ; HARADA Masafumi 徳島大学, ヘルスバイオサイエンス研究部, 教授 (20228654) ; AIHARA Kenichi 徳島大学, ヘルスバイオサイエンス研究部, 講師 (70372711)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 心筋梗塞後心筋リモデリング / 心臓リモデリング / ヘパリンコファクターII / 急性心筋梗塞

Research Abstract

Reperfusion therapy has been shown to reduce the acute phase mortality of patients with acute myocardial infarction (AMI). However, cardiac remodeling in chronic phase reduces cardiac function and results in heart failure. Heparin cofactor II(HCII), a serin peotease inhibitor, exerts pleiotropic effects through inactivation of thrombin action in various tissue. We examined the effects of HCII against cardiac remodeling in patients with AMI. Left ventricular end-diastolic volume significantly decreased at chronic phase in patients with high plasma HCII activity, suggesting anti-remodeling effects of HCII.

Research Products

• [Journal Article] Augmentation Index Does Not Reflect Risk of Coronary Artery Disease in Elderly Patients (2014)
  • Author(s): Hayashi S, Yamada H, Bando M, Hotchi J, Ise T, Yamaguchi K, Iwase T, Soeki T, Wakatsuki T, Tamaki T, Sata M.
  • Journal Title: Circulation Journal Volume: 78 Issue: 5 Pages: 1176-1182
  • DOI: 10.1253/circj.CJ-13-1422
  • NAID: 130003391086
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] The physiological uptake pattern of (18)F-FDG in the left ventricular myocardium of patients without heart disease (2014)
  • Author(s): Nose H, Otsuka H, Otomi Y, Terazawa K, Takao S, Iwamoto S, Iwase T, Yamada H, Sata M, Harada M.
  • Journal Title: The journal of medical investigation : JMI Volume: 61 Pages: 53-58
  • NAID: 130004822717
  • Peer Reviewed
• [Journal Article] Association of lower limb muscle mass and energy expenditure with visceral fat mass in healthy men (2014)
  • Author(s): Yagi S, Kadota M, Aihara K, Nishikawa K, Hara T, Ise T, Ueda Y, Iwase T, Akaike M, Shimabukuro M, Katoh S, Sata M.
  • Journal Title: Diabetology & metabolic syndrome Volume: 6 Issue: 1 Pages: 27-27
  • DOI: 10.1186/1758-5996-6-27
  • Peer Reviewed / Open Access
• [Journal Article] Androgen Receptor Promotes Sex-Independent Angiogenesis in Response to Ischemia and Is Required for Activation of Vascular Endothelial Growth Factor Receptor Signaling (2013)
  • Author(s): Yoshida S, Aihara KI, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama KI, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T.
  • Journal Title: Circulation Volume: 128 Pages: 60-71
  • Peer Reviewed
• [Journal Article] Effects of Telmisartan on Inflammatory Cytokines and the Coronary Plaque Component as Assessed on Integrated Backscatter Intravascular Ultrasound in Hypertensive Patients (2013)
  • Author(s): Yamaguchi K, Wakatsuki T, Soeki T, Niki T, Taketani Y, Oeduka H, Kusunose K, Ise T, Iwase T, Yamada H, Sata M.
  • Journal Title: Circ J Volume: 78 Pages: 240-247
  • NAID: 130003382181
  • Peer Reviewed
• [Journal Article] Ulcer-like projection caused by a penetrating branch to the bronchial artery (2013)
  • Author(s): Ise T, Fujioka K, Iwase T, Hotchi J, Akaike M, Sata M.
  • Journal Title: J Am Coll Cardiol Volume: 61
  • Peer Reviewed
• [Journal Article] Congenital long QT syndrome with compound mutations in the KCNH2 gene (2013)
  • Author(s): Bando S, Soeki T, Matsuura T, Niki T, Ise T, Yamaguchi K, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Akaike M, Aiba T, Shimizu W, Sata M.
  • Journal Title: Heart Vessels Volume: - Issue: 4 Pages: 554-559
  • DOI: 10.1007/s00380-013-0406-2
  • NAID: 130002130326
  • Peer Reviewed / Open Access
• [Journal Article] A case of successful use of microsnare to hold and pull the retrograde guidewire for the intervention to peripheral chronic total occlusion. (2013)
  • Author(s): Tomoya Hara
  • Journal Title: Cardiovascular Intervention and Therapeutics Volume: in press Issue: 3 Pages: 287-90
  • DOI: 10.1007/s12928-013-0158-z
  • Peer Reviewed
• [Journal Article] Constrictive pericarditis with intrapericardial abscess (2013)
  • Author(s): Hara T, Yamada H, Takashima A, Yamasaki H, Ogasawara K, Bando S, Ise T, Niki T, Kusunose K, Ueda Y, Tomita N, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Horiguchi H, Sakashita N, Sata M.
  • Journal Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 77 Pages: 786-788
  • NAID: 10031138972
  • Peer Reviewed
• [Journal Article] Eosinophilic myocarditis due to Churg-Strauss syndrome with markedly elevated eosinophil cationic protein (2013)
  • Author(s): Hara T1, Yamaguchi K, Iwase T, Kadota M, Bando M, Ogasawara K, Bando S, Ise T, Niki T, Ueda Y, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M.
  • Journal Title: International heart journal Volume: 54 Pages: 51-53
  • NAID: 130003364440
  • Peer Reviewed
• [Journal Article] Ulcer-like projection caused by a penetrating branch to the bronchial artery. (2013)
  • Author(s): Ise T, Fujioka K, Iwase T, Hotchi J, Akaike M, Sata M.
  • Journal Title: J Am Coll Cardiol. Volume: 61 Issue: 8 Pages: e147-e147
  • DOI: 10.1016/j.jacc.2012.10.047
  • Peer Reviewed
• [Journal Article] Interval from the Onset of Transmitral Flow to Annular Velocity Is a Marker of LV Filling Pressure. (2013)
  • Author(s): Kusunose K, Yamada H, Nishio S, Tomita N, Niki T, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Sata M
  • Journal Title: JACC Cardiovasc Imaging. Volume: 6 Issue: 4 Pages: 528-530
  • DOI: 10.1016/j.jcmg.2012.10.025
  • Peer Reviewed
• [Journal Article] Pentraxin 3 is a local inflammatory marker in atrial fibrillation (2013)
  • Author(s): Soeki T, Bando S, Uematsu E, Matsuura T, Niki T, Ise T, Kusunose K, Hotchi J, Ueda Y, Tomita N, Yamaguchi K, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
  • Journal Title: Heart Vessels Volume: - Issue: 5 Pages: 27-27
  • DOI: 10.1007/s00380-013-0400-8
  • Peer Reviewed / Open Access
• [Journal Article] Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein (2013)
  • Author(s): Soeki T, Niki T, Uematsu E, Bando S, Matsuura T, Kusunose K, Ise T, Ueda Y, Tomita N, Yamaguchi K, Koshiba K, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Akaike M, Shimabukuro M, Kishimoto I, Kangawa K, Sata M
  • Journal Title: Heart Vessels Volume: 28 Issue: 6 Pages: 795-801
  • DOI: 10.1007/s00380-013-0333-2
  • Peer Reviewed
• [Journal Article] Renin-angiotensin-aldosterone system has a pivotal role in cognitive impairment (2013)
  • Author(s): Yagi S, Akaike M, Ise T, Ueda Y, Iwase T, Sata M.
  • Journal Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 36 Issue: 9 Pages: 753-758
  • DOI: 10.1038/hr.2013.51
  • Peer Reviewed
• [Journal Article] Effects of telmisartan on inflammatory cytokines and coronary plaque component as assessed on integrated backscatter intravascular ultrasound in hypertensive patients (2013)
  • Author(s): Yamaguchi K, Wakatsuki T, Soeki T, Niki T, Taketani Y, Oeduka H, Kusunose K, Ise T, Iwase T, Yamada H, Sata M.
  • Journal Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 78 Pages: 240-247
  • NAID: 130003382181
  • Peer Reviewed
• [Journal Article] Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling (2013)
  • Author(s): Yoshida S, Aihara K, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama K, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T.
  • Journal Title: Circulation Volume: 128 Issue: 1 Pages: 60-71
  • DOI: 10.1161/circulationaha.113.001533
  • Peer Reviewed
• [Journal Article] Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMPK-eNOS signaling pathway (2012)
  • Author(s): Ikeda Y, Aihara KI, Yoshida S, Iwase T, Tajima S, Izawa-Ishizawa Y, Kihara Y, Ishizawa K, Tomita S, Tsuchiya K, Sata M, Akaike M, Kato S, Matsumoto T, Tamaki T.
  • Journal Title: J Biol Chem Volume: 287 Pages: 34256-34263
  • Peer Reviewed
• [Journal Article] Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects (2012)
  • Author(s): Dagvasumberel M, Shimabukuro M, Nishiuchi T, Ueno J, Takao S, Fukuda D, Hirata Y, Kurobe H, Soeki T, Iwase T, Kusunose K, Niki T, Yamaguchi K, Taketani Y, Yagi S, Tomita N, Yamada H, Wakatsuki T, Harada M, Kitagawa T, Sata M
  • Journal Title: Cardiovasc Diabetol Volume: 11 Issue: 1 Pages: 106-106
  • DOI: 10.1186/1475-2840-11-106
  • Peer Reviewed
• [Journal Article] Bicuspid aortic valve endocarditis complicated by perivalvular abscess (2012)
  • Author(s): Hara T et al.
  • Journal Title: J Med Invest Volume: 59 Pages: 261-265
  • Peer Reviewed
• [Journal Article] Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMPK-eNOS signaling pathway. (2012)
  • Author(s): Yasumasa Ikeda
  • Journal Title: The Journal of Biological Chemistry Volume: 287 Issue: 41 Pages: 34256-34263
  • DOI: 10.1074/jbc.m112.353532
  • Peer Reviewed
• [Journal Article] Autologous Peripheral Blood-Derived Mononuclear Cells Induced by Erythropoietin Improve Critical Ischemic Limbs (2012)
  • Author(s): Kanbara T
  • Journal Title: Annals of Vascular Diseases Volume: 5 Issue: 1 Pages: 52-60
  • DOI: 10.3400/avd.oa.11.00070
  • NAID: 130004695429
  • ISSN: 1881-641X, 1881-6428
  • Peer Reviewed
• [Journal Article] Index-beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate (2012)
  • Author(s): Kusunose K, Yamada H, Nishio S, Tomita N, Hotchi J, Bando M, Niki T, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Sata M.
  • Journal Title: J Am Soc Echocardiogr Volume: 25 Issue: 9 Pages: 953-959
  • DOI: 10.1016/j.echo.2012.06.009
  • Peer Reviewed
• [Journal Article] High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension (2011)
  • Author(s): Yagi S, Akaike M, Aihara K, Iwase T, Yoshida S, Sumitomo-Ueda Y, Ikeda Y, Ishikawa K, Matsumoto T, Sata M.
  • Journal Title: Hypertens Res Volume: 34 Pages: 74-78
  • NAID: 10027683061
  • Peer Reviewed
• [Journal Article] Effect of Low-Dose (1 mg/day) Pitavastatin on Left Ventricular Diastolic Function and Albuminuria in Patients With Hyperlipidemia (2011)
  • Author(s): Yagi S, Akaike M, Aihara KI, Iwase T, Ishikawa K, Yoshida S, Sumitomo-Ueda Y, Kusunose K, Niki T, Yamaguchi K, Koshiba K, Taketani Y, Tomita N, Yamada H, Soeki T, Wakatsuki T, Matsumoto T, Sata M.
  • Journal Title: Am J Cardiol Volume: 107 Pages: 1644-1649
  • Peer Reviewed
• [Journal Article] Plasma Heparin Cofactor II Activity is Inversely Associated with Left Atrial Volume and Diastolic Dysfunction in Humans with Cardiovascular Risk Factors (2011)
  • Author(s): Ise T, Aihara KI, Sumitomo-Ueda Y, Yoshida S, Ikeda Y, Yagi S, Iwase T, Yamada H, Akaike M, Sata M, Matsumoto T.
  • Journal Title: Hypertens Res Volume: 34 Pages: 225-231
  • NAID: 10031163157
  • Peer Reviewed
• [Journal Article] Activation of peroxisome proliferator-activated receptorαin megakaryocytes reduces platelet-derived growth factor-BB in platelets (2011)
  • Author(s): Hashizume S, Akaike M, Azuma H, Ishikawa K, Yoshida S, Sumitomo-Ueda Y, Yagi S, Ikeda Y, Iwase T, Aihara KI, Abe M, Sata M, Matsumoto T.
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 138-147
  • Peer Reviewed
• [Journal Article] Activation of peroxisome proliferator-activated receptor alpha in megakaryocytes reduces platelet-derived growth factor-BB in platelets (2011)
  • Author(s): Hashizume, S
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 138-47
  • Peer Reviewed
• [Journal Article] Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors (2011)
  • Author(s): Ise T, Aihara K, Sumitomo-Ueda Y, Yoshida S, Ikeda Y, Yagi S, Iwase T, Yamada H, Akaike M, Sata M, Matsumoto T
  • Journal Title: Hypertens Res Volume: 34 Issue: 2 Pages: 225-31
  • DOI: 10.1038/hr.2010.211
  • NAID: 10031163157
  • Peer Reviewed
• [Journal Article] Serial imaging changes during treatment of Takayasu arteritis with pulmonary artery stenosis (2011)
  • Author(s): Kusunose K, Yamada H, Tomita N, Nishio S, Niki T, Yamaguchi K, Koshiba K, Yagi S, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Akaike M, Sata M.
  • Journal Title: Int J Cardiol. Volume: 148 Issue: 3 Pages: e47-e50
  • DOI: 10.1016/j.ijcard.2009.02.036
  • Peer Reviewed
• [Journal Article] Comparison of chronic-stage histopathological findings among 3 coronary stents implanted in the same patient. (2011)
  • Author(s): Niki T, Wakatsuki T, Yamaguchi K, Kusunose K, Koshiba K, Yagi S, Taketani Y, Iwase T, Tomita N, Yamada H, Soeki T, Akaike M, Sata M
  • Journal Title: Int J Cardiol. Volume: 150 Issue: 1 Pages: e25-e27
  • DOI: 10.1016/j.ijcard.2009.08.032
  • Peer Reviewed
• [Journal Article] Elevated concentrations of pentraxin 3 are associated with coronary plaque vulnerability (2011)
  • Author(s): Soeki, T, et al
  • Journal Title: J Cardiol Volume: 58 Issue: 2 Pages: 151-157
  • DOI: 10.1016/j.jjcc.2011.04.005
  • NAID: 10031159587
  • Peer Reviewed
• [Journal Article] Effect of Low-dose (1mg/day) "Pitavastatin" on Left Ventricular Diastolic Function and Albuminuria in Patients with Hyperlipidemia (2011)
  • Author(s): 赤池雅史
  • Journal Title: Am J Cardiol Volume: 107 Issue: 11 Pages: 1644-1649
  • DOI: 10.1016/j.amjcard.2011.01.054
  • Peer Reviewed
• [Journal Article] Bosentan improves systemic sclerosis-related peripheral circulation insufficiency (2011)
  • Author(s): 赤池雅史
  • Journal Title: Int J Cardiol Volume: 147 Issue: 3 Pages: 472-475
  • DOI: 10.1016/j.ijcard.2011.01.025
  • Peer Reviewed
• [Journal Article] High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension (2011)
  • Author(s): Yagi S, Akaike M, Aihara K, Iwase T, et al
  • Journal Title: Hypertens Res Volume: 34(1) Issue: 1 Pages: 74-78
  • DOI: 10.1038/hr.2010.179
  • NAID: 10027683061
  • Peer Reviewed
• [Journal Article] Acute hemodynamic effects of adaptive servo ventilation in patients with pulmonary hypertension (2011)
  • Author(s): 赤池雅史
  • Journal Title: Int J Cardiol Volume: 148 Issue: 1 Pages: 125-127
  • DOI: 10.1016/j.ijcard.2011.01.074
  • Peer Reviewed
• [Journal Article] Local persistent hypercoagulability after sirolimus-eluting stent implantation in patients with stable angina. (2011)
  • Author(s): Yamaguchi K, Wakatsuki T, Niki T, Kusunose K, Koshiba K, Yagi S, Taketani Y, Iwase T, Tomita N, Yamada H, Soeki T, Akaike M, Sata M
  • Journal Title: Int J Cardiol. Volume: 153 Issue: 3 Pages: 272-276
  • DOI: 10.1016/j.ijcard.2010.08.014
  • Peer Reviewed
• [Presentation] Impact of Cardiac Rehabilitation on Oxidized Stress in Patients with Heart Failure. (2014)
  • Author(s): Ise T, Yagi S, Iwase T, Akaike M, Takashima A, Bando M, Bando S, Matsuura T, Hotchi J, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuiki T, Sata M.
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] Differentiation of left ventricular systolic dysfunction related to cardiac sarcoidosis and other heart diseases using contrast-enhanced cardiovascular magnetic resonance (2013)
  • Author(s): Iwase T, Takao T, Akaike M, Ise T, Yagi S, Yamaguchi K, Yamada H, Nishioka Y, Harada M, Sata M.
  • Organizer: ESC Congress 2013
  • Place of Presentation: Amsterdam RAI (Amsterdam, Netherlands)
• [Presentation] Differentiation of Left Ventricular Systolic Dysfunction Related to Cardiac Sarcoidosis and Other Heart Diseases Using contrast-enhanced Cardiovascular Magnetic Resonance (2013)
  • Author(s): Iwase T, Takao S, Akaike M, Ise T, Niki T, Ueda Y, Yamaguchi K, Taketani Y, Yamada H, Soeki T, Aihara K, Wakatsuki T, Nishioka Y, Harada M, Sata M.
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県、横浜市)
• [Presentation] Differentiation of left ventricular systolic dysfunction related to cardiac sarcoidosis and other heart diseases using contrast-enhanced cardiovascular magnetic resonance. (2013)
  • Author(s): Iwase T, Takao T, Akaike M, Ise T, Yagi S, Yamaguchi K, Yamada H, Nishioka Y, Harada M, Sata M
  • Organizer: ESC Congress 2013
  • Place of Presentation: Amsterdam RAI (Netherlands)
• [Presentation] 左室収縮不全を伴う心サルコイドーシスと他の心疾患鑑別におけるガドリニウム遅延造影定量評価の有用性 (2013)
  • Author(s): 岩瀬俊、高尾正一郎、赤池雅史、伊勢孝之、八木秀介、山口浩司、山田博胤、添木武、若槻哲三、西岡安彦、原田雅史、佐田政隆
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: ホテル日航熊本、熊本市現代美術館（熊本県）
• [Presentation] 3ステラ非造影心臓MRI検査が左室内壁在血栓の検出ならびに治療方針決定に有用であった無症候性心筋虚血の1例 (2013)
  • Author(s): 岩瀬俊、高尾正一郎、太田理絵、山口浩司、赤池雅史、伊勢孝之、山田博胤、添木武、若槻哲三、原田雅史、佐田政隆
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: ホテル日航熊本、熊本市現代美術館（熊本県）
• [Presentation] Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Left Heart Failure (2012)
  • Author(s): Ise T, Yagi S, Iwase T, Akaike M, Kadota M, Hara T, Bando S, Niki T, Hotchi J, Tomita N, Yamaguchi K, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M.
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (Los Angeles, America)
• [Presentation] The tissue characteristics of coronary plaque with microchannel structure in patients with Coronary Artery Disease assessed by OCT and IB-IVUS. (2012)
  • Author(s): Niki T et al
  • Organizer: ESC Congress 2012
  • Place of Presentation: Internationales Congress Center Munchen, Germany
• [Presentation] Ghrelin protects the heart against ischemia-induced arrhythmias by modulating autonomic nerve activity. (2012)
  • Author(s): Soeki T et al
  • Organizer: ESC Congress 2012
  • Place of Presentation: Internationales Congress Center Munchen, Germany
• [Presentation] Effect of Cardiac Rehabilitation with Supervised Exercise Training on Urinary Albumin Excretion in Patients with Cardiovascular Disease. (2012)
  • Author(s): Kimura S et al
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center, USA
• [Presentation] Cardiac Rehabilitation Reduces Levels of Oxidized LDL. (2012)
  • Author(s): Takashima A et al
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center, USA
• [Presentation] Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Left Heart Failure. (2012)
  • Author(s): Ise T et al
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center, USA
• [Presentation] Effects of Additional Eicosapentaenoic Acid to Statin Therapy on Inflammatory Cytokines and the Tissue Characterization of Coronary Plaque Assessed by Integrated Backscatter Intravascular Ultrasound Systems. (2012)
  • Author(s): Niki T et al
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center, USA
• [Presentation] Telmisartan Reduces Coronary Plaque Vulnerability and Instent-neointimal Proliferation in Hypertensive Patients. (2012)
  • Author(s): Yamaguchi K et al
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center, USA
• [Presentation] Required for Cellular Survival and Angiogenesis in Response to Ischemia via Activation of VEGF Receptor Signaling Pathway Regardless of Sex. (2012)
  • Author(s): Yoshida S et al
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center, USA
• [Presentation] Detection of Cardiac Involvement in Patients with Sarcoidosis Using Cardiac Magnetic Resonance (2011)
  • Author(s): Iwase T, Takao S, Akaike M, Ise T, Niki T, Kusunose K, Sumitomo-Ueda Y, Tomita N, Yamaguchi K, Taketani Y, Yamada H, Soeki T, Aihara K, Wakatsuki T, Harada M, Sata M.
  • Organizer: AHA Scientific Sessions 2011
  • Place of Presentation: Orange County Convention Center (Orlando, America)
• [Presentation] Detection of Cardiac Involvement in Patients with Sarcoidosis Using Cardiac Magnetic Resonance. (2011)
  • Author(s): Iwase T
  • Organizer: AHA Scientific Sessions 2011
  • Place of Presentation: Orlando, America
• [Presentation] サルコイドーシス心病変検出における心臓MRI検査の有用性 (2011)
  • Author(s): 岩瀬俊
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] 心臓MRIによるサルコイドーシス心病変検出の有用性 (2011)
  • Author(s): 岩瀬俊
  • Organizer: 第31回日本サルコイドーシス／肉芽腫性疾患学会総会
  • Place of Presentation: 愛知県産業労働センター（名古屋市）
• [Presentation] 冠動脈プラークに対するスタチンへのEPA製剤add on効果の検討－Integrated backscatter IVUSおよび局所Biomaker観察の観点から－ (2011)
  • Author(s): 若槻哲三
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] 心房細動における局所炎症反応に関する検討 (2011)
  • Author(s): 添木武
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] 冠動脈プラークに対するテルミサルタンの多面的効果の検討－Integrated backscatter IVUS観察と炎症性サイトカインによる観点から－ (2011)
  • Author(s): 山口浩司
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] 左心不全に合併した肺高血圧症における三尖弁輪運動速波形の特徴：HFPEFとHFREFの差異 (2011)
  • Author(s): 玉井利奈
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] 冠動脈硬化症を最も反映する非侵襲的血管検査法についての検討 (2011)
  • Author(s): 西尾進
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] 膠原病における潜在性肺動脈性高血圧症の検出：運動負荷心エコー法の有用性 (2011)
  • Author(s): 山田博胤
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] グレリンによる自律神経およびConnexin43発現調節を介した抗不整脈作用の検討 (2011)
  • Author(s): 坂東左知子
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] 三尖弁輪運動速波形による肥大型心筋症と高血圧性心疾患の鑑別 (2011)
  • Author(s): 林修司
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] 心房細動における僧帽弁口血流速拡張早期波の心拍変動性の臨床的意義 (2011)
  • Author(s): 冨田紀子
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] Successful Autologous Peripheral Blood Stem Cell Transplantation for Primary Cardiac Amyloidosis Patients with Heart Failure : three cases report. (2011)
  • Author(s): 伊勢孝之
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: かごしま県民交流センター（鹿児島県）