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Role of Epac in cardiac fibrosis and its clinical application for heart failure

Research Project

Project/Area Number 23591087
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTsurumi University

Principal Investigator

OKUMURA Satoshi  鶴見大学, 歯学部, 教授 (60233475)

Co-Investigator(Kenkyū-buntansha) SATO Motohiko  愛知医科大学, 医学部, 教授 (40292122)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsシグナル伝達 / 循環器高血圧 / サイクリックAMP / 心不全 / 遺伝子改変マウス
Research Abstract

In order to examine the role of Epac1 (exchange protein directly activated by cyclic AMP) on cardiac fibrosis, chronic isoproterenol (ISO) infusion (60mg/kg/day for 7 days) was performed in Epac1-null mice (Epac1KO) and wild-type controls (WT). Cardiac fibrosis was significantly inhibited in Epac1KO, compared to WT. In order to examine the mechanism, we examined the role of Epac1 in the following 3 steps : Step-1) Production of collagen fiber Step-2) Cross-linking of collagen fiber by lysyl oxidase (LOX) Step-3) Degradation of collagen fiber by matrix mettaloproteinase (MMT). Our data in this study shows that cardiac fibrosis was reduced through the inhibition of step-3.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (70 results)

All 2014 2013 2012 2011 Other

All Journal Article (32 results) (of which Peer Reviewed: 29 results,  Open Access: 2 results) Presentation (22 results) Book (2 results) Remarks (8 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 2 results)

  • [Journal Article] Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses2014

    • Author(s)
      Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemera M, Ichikawa Y, Yokoyama U, Sato m, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y
    • Journal Title

      J Clin Invest

      Volume: 124 Pages: 2785-2801

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protection of cardiomyocytes from the hypoxia-mediated injury by a peptide targeting the G-protein signaling 82014

    • Author(s)
      Sato M, Hiraoka M, Sakima M, Yamane Y, Fujita T, Okumura S, Ishikawa Y
    • Journal Title

      PLoS One

      Volume: 14

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article]2014

    • Author(s)
      Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T, Feng X, Oda K, Miyajima A, Makino A, Iwai M, Fujita T, Yokoyama U, Okumura S, Sato M, Eguchi H, Tohnai I, Ishikawa Y
    • Journal Title

      J Physiol Sci

      Volume: 64 Pages: 177-183

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the masticatory demand on the rat mandibular development2014

    • Author(s)
      Hichijo N, Kawai N, Mori H, Sano R, Ohnuki Y, Okumura S, langenbach GE, Tanaka E
    • Journal Title

      J Oral Rehabil

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epac1-dependent phosphorylamban phosphorylation mediates the cardiac response to stresses2014

    • Author(s)
      Okumura S et al.
    • Journal Title

      J Clin Invest

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protection of cardiomyocytes from the hypoxia-mediated injury by a peptide targeting the activator of G-protein signaling 8.2014

    • Author(s)
      Sato M, Hiraoka M, Suzuki H, Sakima M, Mamun, AA, Yamane Y, Fujita T, Yokoyama U, Okumura S, and Ishikawa Y.
    • Journal Title

      PLoS ONE.

      Volume: 9 Issue: 3 Pages: e91980-e91980

    • DOI

      10.1371/journal.pone.0091980

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperthermia generated with ferucarbotran (Resovis®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells.2014

    • Author(s)
      Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T Fujita T, Yokoyama U, Okumura S, Feng X, Ito K, Miyajima A, Makino A, Iwai M, Eguchi H, I wai T, and Ishikawa Y.
    • Journal Title

      J. Physiol. Sci.

      Volume: 64 Issue: 3 Pages: 177-183

    • DOI

      10.1007/s12576-014-0309-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of the masticatory demand on the rat mandibular development2014

    • Author(s)
      Hichijo N, Okumura S et al
    • Journal Title

      J Oral Rehabil

      Volume: in press Issue: 8 Pages: 581-587

    • DOI

      10.1111/joor.12171

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 咀嚼筋肥大刺激のミオシン重鎖のサブタイプスイッチングに与える効果2014

    • Author(s)
      奥村敏 他
    • Journal Title

      日本病態生理学会雑誌

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 全身の健康増進における口腔生理機能の重要性2014

    • Author(s)
      奥村敏 他
    • Journal Title

      日本生理学会雑誌

      Volume: 76 Pages: 76-77

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Effect of protein kinase A on the phosphorylation status and transverse stiffness of cardiac myofibrils2013

    • Author(s)
      Ohnuki Y, Yamada T, Mototani Y, Umeki D, Shiozawa K, Fujita T, Saeki Y, Okumura S
    • Journal Title

      J Pharamacol Sci

      Volume: 123 Pages: 279-283

    • NAID

      130003382605

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of masseter muscleβ2-adrenergic signaling in regulation of muscle activity, myosin heavy chain transition, and hypertrophy2013

    • Author(s)
      Ohnuki Y, Umeki D, Cai W, Kawai N, Mototani Y, Shiozawa K, Jin HL, Fujita T, Tanaka E, Saeki Y, Okumura S
    • Journal Title

      J Pharmacol Sci

      Volume: 123 Pages: 36-46

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chronic Akt/mTOR inhibition by rapamycin on mechanical overload-induced hypertrophy and myosin heavy chain transition in masseter muscle2013

    • Author(s)
      Umeki D, Ohnuki Y, Mototani Y, Shiozawa K, Fujita T, Nakamura Y, Saeki Y, Okumura S
    • Journal Title

      J Pharmacol Sci

      Volume: 122 Pages: 278-288

    • NAID

      10031196201

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of protein kinase A on the phosphorylation status and transverse stiffness of cardiac myofibrils2013

    • Author(s)
      Ohnuki Y, Okumura S et al.
    • Journal Title

      J Pharmacol Sci

      Volume: 123 Pages: 279-283

    • NAID

      130003382605

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of masseter muscle beta2-adrenergic signaling in regulation of muscle activity, myosin heavy chain transition, and hypertrophy2013

    • Author(s)
      Ohnuki Y, Okumura S et al
    • Journal Title

      J Pharamacol Sci

      Volume: 123 Pages: 36-46

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chronic Akt/mTOR inhibition by rapamycin on mechanical overload-induced hypertrophy and myosin heavy chain transition in masseter muscle2013

    • Author(s)
      Umeki D, Okumura S et al
    • Journal Title

      J Pharamacol Sci

      Volume: 122 Pages: 278-288

    • NAID

      10031196201

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯学部における生理学教育について2013

    • Author(s)
      奥村敏
    • Journal Title

      日本生理学会雑誌

      Volume: 75 Pages: 229-230

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Pharmacological stimulation of type 5 adenylyl cyclase stabilizes heart rate under both microgravity and hypergravity induced by parabolic flight2012

    • Author(s)
      Bai Y, Tsunematsu T, Jiao Q, Ohnuki Y, Mototani Y, Shiozawa K, Jin M, Cai W, Jin HL, Fujita T, Ichikawa Y, Suita K, Kurotani R, Yokoyama U, Sato M, Iwatsubo K, Ishikawa Y, Okumura S
    • Journal Title

      J Pharmacol Sci

      Volume: 119 Pages: 381-389

    • NAID

      10031071685

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of EP4 signaling attenuate aortic aneurysm formation2012

    • Author(s)
      Yokoyama U, Ishiwata R, Jin MH, Kato Y, Suzuki O, Jin H, Ichikawa Y, Kumagaya S, Katayama Y, Fujita T, Okumura S, Sato M, Sugimoto Y, Aoki H, Suzuki S, Masuda M, Minamisawa S, Ishikawa Y
    • Journal Title

      Plos One

      Volume: 7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of phosphodiesterase type 3 dilates the rat ductus arteriosus without inducing intimal thickening2012

    • Author(s)
      Ichikawa Y, Yokoyama U, Iwamoto M, Oshikawa J, Okumura S, Sato M, Yokota S, Masuda M, Asou T, Ishikawa Y
    • Journal Title

      Circ J

      Volume: 76 Pages: 2456-2464

    • NAID

      10030875150

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia inprostate cancer cell2012

    • Author(s)
      Fukumura H, Sato M, Kezuka K, Sato I, Feng X, Okumura S, Fujita T, Yokoyama U, Eguchi H, Ishikawa Y, Saito T
    • Journal Title

      J Physiol Sci

      Volume: 62 Pages: 251-257

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article]2012

    • Author(s)
      Iwatsubo K, Brav C, Uechi M, Baljinnyam E, Nakamura T, Umemura M, Lai L, gao S, Yan L, Zhao X, Park M, Qiu H, Okumura S, Iwatsubo M, Vatner DE, Vatner SF, Ishikawa Y
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 302

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight2012

    • Author(s)
      Bai Y, et al.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 119 Issue: 4 Pages: 381-389

    • DOI

      10.1254/jphs.12102FP

    • NAID

      10031071685

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of EP4 signaling attelluates aortic aneurysm formation2012

    • Author(s)
      Yokoyama U
    • Journal Title

      PLoS One

      Volume: 7 Issue: 5 Pages: e36724-e36724

    • DOI

      10.1371/journal.pone.0036724

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells.2012

    • Author(s)
      Fukumura H, et al.
    • Journal Title

      J. Physiol. Sci.

      Volume: 62 Issue: 3 Pages: 251-257

    • DOI

      10.1007/s12576-012-0204-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase.2012

    • Author(s)
      Iwatsubo K, Bravo C, Uechi M, Baljinnyam E, Nakamura T, Umemura M, Lai L, Gao S, Yan L, Park M, Qiu H, Okumura S, Iwatwsubo M, Vatner DE, Vatner SF, and Ishikawa Y.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 302 Issue: 12 Pages: H2622-H2628

    • DOI

      10.1152/ajpheart.00190.2012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Secretoglobin 3A2 supresses bleomycin-induced pulmonary fibrosis by transforming growth factorβsignaling down-regulation2011

    • Author(s)
      Kurotani R, Okumura S, Matsubara T, Yokoyama U, Buckley JR, Tomita T, Kezuka K, Nagano T, Esposito D, Taylor TE, Gillette WK, Ishikawa Y, Abe H, Ward JM, Kimura S
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 19682-19692

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of transforming factor E3 (TFE3) as a receptor-independent activator of Gα162011

    • Author(s)
      Sato M, Hiraoka M, Suzuki H, Bai Y, Kurotani R, Yokoyama U, Okumura S, Cismowski MJ, Lanier SM, Ishikawa Y
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 17766-17776

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of cytochrome p450 in ischemic heart disease2011

    • Author(s)
      Sato M, Yokoyama U, Fujita T, Okumura S, Ishikawa Y
    • Journal Title

      Curr Drug Metab

      Volume: 12 Pages: 526-532

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGFbeta signaling down-regulation.2011

    • Author(s)
      Kurotani R, et al
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Issue: 22 Pages: 19682-19692

    • DOI

      10.1074/jbc.m111.239046

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The roles of cytochrome P450 in ischemic heart disease2011

    • Author(s)
      Sato M, Yokoyama U, Fujita T, Okumura S, Ishikawa Y
    • Journal Title

      Current Drug Metabolism

      Volume: 12 Pages: 526-532

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of transcription factor E3 (TFE3) as areceptor-independent activator of G α 16: Gene regulation by nuclear Ga subunit and it s activator.2011

    • Author(s)
      Sato M, et al
    • Journal Title

      J Biol Chem.

      Volume: 286 Issue: 20 Pages: 17766-17776

    • DOI

      10.1074/jbc.m111.219816

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Vidarabine, a selective cardiac adenylyl cyclase inhibitor, prevents ventricular arrhythmia in Calsequestrin 2 knockout mouse2014

    • Author(s)
      Suita K, Okumur a S, et al.
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Roles of Epac in masseter muscle hypertrophy induced by chronic stimulation of beta 2 adorenoreceptor2014

    • Author(s)
      Ohnuki Y, Okumura S, et al.
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Vidarabine, a selective cardiac adenylyl cyclase inhibitor, prevents ventricular arrhythmia in Calsequestrin 2 knockout mouse2014

    • Author(s)
      Suita K, Okumur a S, et al.
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Final Research Report
  • [Presentation] Roles of Epac in masseter muscle hypertrophy induced by chronic stimulation of beta2-adrenoreceptor2014

    • Author(s)
      Ohnuki Y, Okumura S et al.
    • Organizer
      The 91 Annual Meeting of the Physiological Societyof Japan
    • Place of Presentation
      Kagoshima University
    • Related Report
      2013 Annual Research Report
  • [Presentation] Vidarabine, a selective cardiac adenylyl cyclase inhibitor, prevents ventricular arrhythmias in Calsequestrin 2 knockput mice2014

    • Author(s)
      Suita K, Okumura S et al.
    • Organizer
      The 91 Annual Meeting of the Physiological Societyof Japan
    • Place of Presentation
      Kagoshima University
    • Related Report
      2013 Annual Research Report
  • [Presentation] Vidarabine, a selective cardiac adenylyl cyclase inhibitor, prevents ventricular arrhythmias in Calsequestrin 2 knockput mice2014

    • Author(s)
      Suita K, Okumura S et al.
    • Organizer
      The 78 th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Tokyo International Forum
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of beta2-adrenoceptor agonists on function and phenotype of rat masseter muscle2013

    • Author(s)
      Onuki Y, Okumura S
    • Organizer
      The 55th Annual Meeting of Japanese Association for Oral Biology
    • Place of Presentation
      Okayama University
    • Related Report
      2013 Annual Research Report
  • [Presentation] Relationship between natural bite size and body mass index (BMI)2013

    • Author(s)
      Shiozawa K, Okumura S
    • Organizer
      The 55th Annual Meeting of Japanese Association for Oral Biology
    • Place of Presentation
      Okayama Universuty
    • Related Report
      2013 Annual Research Report
  • [Presentation] George E Brown Memor ial Lecture and Molecular Mechanism of Hear t Failure2012

    • Author(s)
      Okumur a S, et al
    • Organizer
      Disruption of Epac1 decreases phosphorylation of phospholamban and protects the heart against stress Amer ican Hear t Association Scientifc Scission 2012
    • Place of Presentation
      Los Angeles in USA(Oral presentation)
    • Related Report
      2013 Final Research Report
  • [Presentation] Epac activation protects heart from interleukin-6-induced cardiac dysfunction by inhibiting STAT/iNOS signaling2011

    • Author(s)
      Okumur a S,, et al.
    • Organizer
      American Heart Association Scientific Sessions 2011
    • Place of Presentation
      Orlando in USA(Oral presentation)
    • Related Report
      2013 Final Research Report
  • [Presentation] Disruption of Epac1 protects heart from catecholamine-mediated cardiac fibrosis2011

    • Author(s)
      Okumura S, et al.
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Final Research Report
  • [Presentation] Epac activation protects heart from interleukin-6-induced cardiac dysfunction by inhibiting STAT/iNOS signaling2011

    • Author(s)
      Satoshi Okumura, Meihua Jin, Fumika Kawamata, Hui-Ling Jin, Wenqian Cai, Yunzhe Bai, Kenji Suita, Yuko Hidaka, Takashi Tsunematsu, Yoshihiro Ishikawa
    • Organizer
      American Heart Association Scientific Sessions 2011
    • Place of Presentation
      Orange County Convention Center, Orlando, Florida, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Disruption of Epac1 Protects Heart from Catecholamine-mediated Cardiac Fibrosis2011

    • Author(s)
      Okumura S, Cai W, Jin M, Bai Y, Tsunematsu T, HidakaY, Kurotani R, Ishikawa Y
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Related Report
      2011 Research-status Report
  • [Presentation] Effects of beta-2 adrenoceptor agonists on function and phenotype of rat masseter muscle

    • Author(s)
      Ohnuki Y, Okumura S, et al.
    • Organizer
      第51回歯科基礎医学会総会
    • Place of Presentation
      岡山大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Disruption of Epac1 decreases phosphorylation of phospholamban and protects the heart against stress

    • Author(s)
      Satoshi Okumura et al
    • Organizer
      American Heart Association Scientific Scission 2012
    • Place of Presentation
      Los Angeles Convention Center (Los Angeles, CA, USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Roles of Epac in muscle hypertrophy and fiber-type transition induced by beta2-adrenoceptor agonist in masseter muscle

    • Author(s)
      Yoshiki Ohnuki, Satoshi Okumura et al
    • Organizer
      The 90 th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      TOWER HALL FUNABORI (Tokyo.Japan)
    • Related Report
      2012 Research-status Report
  • [Presentation] Pharamacological inhibition of STAT3 protects heart from lipopolysaccharide-induced cardiac dysfunction through the inhibition of Jak2/STAT3/iNOS signaling

    • Author(s)
      Huiling Jin, Satoshi Okumura et al.
    • Organizer
      The 90 th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      TOWER HALL FUNABORI (Tokyo.Japan)
    • Related Report
      2012 Research-status Report
  • [Presentation] Vidarabine, an anti-herpesvirus agent, prevents atrial fibrillation in mice

    • Author(s)
      Kenji Suita, Satoshi Okumura et al.
    • Organizer
      The 90 th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      TOWER HALL FUNABORI (Tokyo.Japan)
    • Related Report
      2012 Research-status Report
  • [Presentation] Epac1 pathway plays an important role for thedevelopment of heart failure through the activation of PKA

    • Author(s)
      Cai Weniqian, Satoshi Okumura et al.
    • Organizer
      The 90 th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      TOWER HALL FUNABORI (Tokyo.Japan)
    • Related Report
      2012 Research-status Report
  • [Presentation] Relationship between masticatory perforformance and nasticatory behavior in humans

    • Author(s)
      Kouichi Shiozawa, Satoshi Okumura
    • Organizer
      The 90 th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      TOWER HALL FUNABORI (Tokyo.Japan)
    • Related Report
      2012 Research-status Report
  • [Presentation] 新規サイクリックAMP活性化因子Epacの咬筋肥大における役割

    • Author(s)
      大貫芳樹、奥村敏
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      奥羽大学(福島)
    • Related Report
      2012 Research-status Report
  • [Presentation] 咀嚼能率と一口量との関係

    • Author(s)
      塩澤光一、奥村敏
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      奥羽大学(福島)
    • Related Report
      2012 Research-status Report
  • [Book] 歯科基礎生理学第6版(共著)2014

    • Related Report
      2013 Final Research Report
  • [Book] 基礎歯科生理学2014

    • Author(s)
      奥村敏 共著
    • Total Pages
      436
    • Publisher
      医歯薬出版
    • Related Report
      2013 Annual Research Report
  • [Remarks] 鶴見大学 歯学部 生理学講座

    • URL

      http://dent.tsurumi-u.ac.jp/guide/course/basic/331

    • Related Report
      2013 Final Research Report
  • [Remarks] 横浜市立大学 医学部 循環制御医学

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/

    • Related Report
      2013 Final Research Report
  • [Remarks] 愛知医科大学 医学部 生理学

    • URL

      http://www.aichi-med-u.ac.jp/physio2/

    • Related Report
      2013 Final Research Report
  • [Remarks] 鶴見大学歯学部生理学講座

    • URL

      http://dent.tsurumi-u.ac.jp/guide/course/basic/331

    • Related Report
      2013 Annual Research Report
  • [Remarks] 鶴見大学歯学部生理学

    • URL

      http://dent.tsurumi-u.ac.jp/guide/course/basic/331

    • Related Report
      2012 Research-status Report
  • [Remarks] 横浜市立大学大学院医学研究科 循環制御医学

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/

    • Related Report
      2012 Research-status Report
  • [Remarks] 横浜市立大学 循環制御医学ホームページ

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/index.html

    • Related Report
      2011 Research-status Report
  • [Remarks] 鶴見大学 生理学ホームページ

    • URL

      http://dent.tsurumi-u.ac.jp/guide/course/basic/331

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] ビダラビンによる心房細動治療2012

    • Inventor(s)
      石川義弘、奥村 敏、吹田憲治
    • Industrial Property Rights Holder
      横浜市立大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-08-01
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] ビダラビンによる心房細動治療2012

    • Inventor(s)
      石川義弘、奥村敏、吹田憲治
    • Industrial Property Rights Holder
      石川義弘、奥村敏、吹田憲治
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-08-01
    • Related Report
      2012 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] アデニル酸シクラーゼの活性調節剤2011

    • Inventor(s)
      石川義弘、奥村 敏、星野雄二郎、井上 誠一
    • Industrial Property Rights Holder
      横浜市立大学、横浜国立大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-10-20
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] ビダラビンによる心房細動治療2011

    • Inventor(s)
      石川義弘、奥村 敏、吹田憲治
    • Industrial Property Rights Holder
      横浜市立大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2011-222421
    • Filing Date
      2011-10-07
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] ビダラビンによる心房細動治療2011

    • Inventor(s)
      石川義弘、奥村 敏、吹田憲冶
    • Industrial Property Rights Holder
      石川義弘、奥村 敏、吹田憲冶
    • Industrial Property Number
      2011-222421
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] アデニル酸シクラーゼの活性調節剤2011

    • Inventor(s)
      石川義弘、奥村 敏、星野雄二郎、井上誠一
    • Industrial Property Rights Holder
      石川義弘、奥村 敏、星野雄二郎、井上誠一
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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