Associations of TF and F7 with pathogenesis of asthma and COPD

• Project/Area Number: 23591110
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: KONNO Satoshi 北海道大学, 大学病院, 講師 (20399835)
• Co-Investigator(Kenkyū-buntansha): ISADA Akira 北海道大学, 北海道大学病院, 特任助教 (80374289) ; NASUHARA Yasuyuki 北海道大学, 北海道大学病院, 准教授 (30322811)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 閉塞性肺疾患 / 気管支喘息 / COPD / 凝固系

Research Abstract

Levels of tissue factor(TF) and factor7 in BALF were signnificantly increased after OVA challenge in two murine models of asthma (acute and chronic models). Intraperitoneal administration of TF-factor7 inhibitor significantly decreased the number of eosinophils in BALF, OVA-IgE levels in serum and bronchial hyperresponsiveness in these moedels, suggesting the potential of TF-factor7 as a novel therapeutic target for asthma treatment. In genetic studies, we conducted case (asthma)-control studies for several genes related with coagulation cascade, including TF,F2R,CC16 and CAT and significant associations of several SNPs in these genes and asthma were identified.

Research Products

• [Journal Article] CAT -262 C>T polymorphism is associated with asthma in smokers and with a nonemphysematous phenotype of chronic obstructive pulmonary disease (2014)
  • Author(s): Taniguchi N, Konno S, Isada A, Hattori T, Shimizu,K, Kimura H, Maeda Y, Makita H, Huang SK, Hizawa N, Nishimura M
  • Journal Title: Ann Allergy Asthma Immunol Volume: (in press)
  • Peer Reviewed
• [Journal Article] CAT -262 C>T polymorphism is associated with asthma in smokers and with a nonemphysematous phenotype of chronic obstructive pulmonary disease (2014)
  • Author(s): Tanigichi N
  • Journal Title: Annals of Allergy, Asthma & Immunology. Volume: in press
  • Peer Reviewed
• [Journal Article] The CC16 A38G polymorphism is associated with asymptomatic airway hyper-responsiveness and development of late-onset asthma (2013)
  • Author(s): Taniguchi N, Konno S, Hattori T, Isada A, Shimizu K, Shimizu K, Shijubo N, Huang SK, Hizawa N, Nishimura M
  • Journal Title: Ann Allergy Asthma Immunol Volume: 111 Pages: 376-381
  • Peer Reviewed
• [Journal Article] The CC16 A38G polymorphism is associated with asymptomatic airway hyper-responsiveness and development of late-onset asthma (2013)
  • Author(s): Taniguchi N
  • Journal Title: Annals of Allergy, Asthma & Immunology Volume: 111 Issue: 5 Pages: 376-381
  • DOI: 10.1016/j.anai.2013.08.005
  • Peer Reviewed
• [Presentation] カタラーゼ遺伝子(CAT)多型が気管支喘息発症に及ぼす影響 (2012)
  • Author(s): 谷口菜津子
  • Organizer: 日本アレルギー学会秋季学術集会
  • Place of Presentation: グランキューブ大阪(大阪市)
  • Year and Date: 2012-11-30
• [Presentation] Clara cell 10kDa protein(CC10)遺伝子多型が気道過敏性、喘息発症に及ぼす影響 (2011)
  • Author(s): 谷口菜津子、今野哲、高橋大輔、服部健史、檜澤伸之、西村正治
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 日京王プラザホテル(東京)
  • Year and Date: 2011-11-10
• [Presentation] Clara cell 10kDa protein(CC10)遺伝子多型が気道過敏性、喘息発症に及ぼす影響 (2011)
  • Author(s): 谷口菜津子
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] カタラーゼ遺伝子(CAT)多型が気管支喘息発症に及ぼす影響
  • Author(s): 谷口菜津子
  • Organizer: 日本アレルギー学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪）