Activation of the prefrontal cortex is associated with exertional dyspnea in COPD

• Project/Area Number: 23591128
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kinki University
• Principal Investigator: HIGASHIMOTO Yuji 近畿大学, 医学部, 講師 (70316115)
• Co-Investigator(Renkei-kenkyūsha): TOHDA Yuji 近畿大学, 医学部, 教授 (50167524) ; FUKUDA Kanji 近畿大学, 医学部, 教授 (50201744)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 閉塞性肺疾患 / 脳皮質活動 / 運動負荷 / 近赤外線分光法 / 前頭葉 / 慢性閉塞性肺疾患 / 呼吸困難 / 低酸素血症 / 間質性肺炎 / 前頭葉皮質 / 気管支拡張薬 / COPD / 脳活動 / 前頭前野領域

Research Abstract

Background Exertional dyspnea is the primary symptom that limits exercise for patients with chronic obstructive pulmonary disease (COPD). It is unknown which activated brain area is associated with this symptom in COPD patients.
Objectives To investigate the activation of cortical areas in COPD patients associated with dyspnea during exercise. Methods COPD patients and age-matched controls performed mild intensity constant-work rate cycle exercises for 10 minutes while cerebral hemodynamics and oxygenation were measured by near-infrared spectroscopy (NIRS). Results Oxy-Hb concentration was significantly increased in the prefrontal region during exercise in both groups, but not in temporoparietal regions. Dyspnea scores were positively correlated with changes in oxy-Hb concentrations of the prefrontal regions in both groups. Conclusions Exertional dyspnea was related to activation (oxygenation) of the prefrontal cortex in COPD patients and control subjects.

Research Products

• [Journal Article] Effect of therapeutic touch on brain activation of preterm infants in response to sensory punctate stimulus : A near-infrared spectroscopy-based study (2013)
  • Author(s): Honda N., Higashimoto Y., Fukuda K, (他4名)
  • Journal Title: Archives of disease in childhood Fetal and neonatal Volume: edition 98
  • URL: http://adc.bmj.com/
  • Peer Reviewed
• [Journal Article] 【copd-その病態と最新治療】ステロイド薬の使い方(吸入・経口) (2013)
  • Author(s): 東本有司,東田有智
  • Journal Title: カレントテラピー Volume: 31 Pages: 513-517
  • URL: http://www.lifemedicom.co.jp/
• [Journal Article] Effect of therapeutic touch on brain activation of preterm infants in response to sensory punctate stimulus: A near-infrared spectroscopy-based study. (2013)
  • Author(s): Honda N, Ohgi S, Wada N, Loo KK, Higashimoto Y, Fukuda, K
  • Journal Title: Archives of disease in childhood Fetal and neonatal edition Volume: 98
  • Peer Reviewed
• [Journal Article] 【COPD-その病態と最新治療】 ステロイド薬の使い方(吸入・経口) (2013)
  • Author(s): 東本 有司, 東田 有智
  • Journal Title: カレントテラピー Volume: 31 Pages: 513-517
• [Journal Article] 【COPDの上手な診療】喘息を合併したcopdの治療 (2012)
  • Author(s): 東本有司,東田有智
  • Journal Title: 臨牀と研究 Volume: 89 Pages: 1061-1065
• [Journal Article] 呼吸リハビリテーションと非侵襲的陽圧換気療法が奏効し酸素療法から離脱できた脊椎後側彎症の1例 (2012)
  • Author(s): 本田憲胤, 東本有司, 東田有智, (他8名)
  • Journal Title: 総合リハビリテーション Volume: 40 Pages: 1447-1451
  • URL: http://www.igaku-shoin.co.jp/
  • Peer Reviewed
• [Journal Article] 低酸素血症によるせん妄の可能性 (2012)
  • Author(s): 東田 有智, 東本有司:
  • Journal Title: 日本医事新報 Volume: 4619 Pages: 53-55
  • Peer Reviewed
• [Journal Article] 【copdの上手な診療】 喘息を合併したcopdの治療 (2012)
  • Author(s): 東本有司, 東田 有智
  • Journal Title: 臨牀と研究 Volume: 89 Pages: 1061-1065
  • Peer Reviewed
• [Journal Article] Effect of therapeutic touch on brain activation of preterm infants in response to sensory punctate stimulus (2012)
  • Author(s): Honda N, Ohgi S, Wada N, Loo KK, Higashimoto Y, Fukuda K
  • Journal Title: Archives of disease in childhood Fetal and neonatal edition Volume: in press
  • Peer Reviewed
• [Journal Article] Clinical and inflammatory factors associated with body mass index in elderly patients with chronic obstructive pulmonary disease (2011)
  • Author(s): Higashimoto Y(他8名)., Honda N, Tohda Y
  • Journal Title: Geriatr Gerontol Int Volume: 11 Pages: 32-38
  • NAID: 10027913481
  • URL: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1447-0594
  • Peer Reviewed
• [Journal Article] Activation of the prefrontal cortex is associated with exertional dyspnea in chronic obstructive pulmonary disease (2011)
  • Author(s): Higashimoto Y.(他13名)
  • Journal Title: Respiration Volume: 82 Pages: 492-500
  • URL: http://www.karger.com/Journal/Home/224278
  • Peer Reviewed
• [Journal Article] 【copdの治療・管理update】増悪期の管理増悪時の薬物療法 (2011)
  • Author(s): 東本有司,東田有智
  • Journal Title: 日本胸部臨床 Volume: 70
  • URL: http://www.kokuseido.co.jp/
• [Journal Article] 三宅式記銘力検査における得点と脳血流の変化 (2011)
  • Author(s): 杉谷竜司,東本有司
  • Journal Title: 理学療法科学 Volume: 26 Pages: 537-540
  • NAID: 10029619193
  • URL: http://spts.jpn.com/
• [Journal Article] 健常若年者および高齢者における労作時呼吸困難と大脳皮質ヘモグロビン濃度の関係 (2011)
  • Author(s): 本田憲胤,東本有司,東田有智, (他7名)
  • Journal Title: 日本呼吸ケア・リハ学会誌 Volume: 21 Pages: 142-147
  • NAID: 130005164141
  • URL: http://www.jsrcr.jp/
• [Journal Article] 慢性閉塞性肺疾患患者における前頭葉機能の検討frontal assessment batteryを用いて (2011)
  • Author(s): 岡島聡, 東本有司, 本田憲胤, 東田有智, 他4名
  • Journal Title: 日本呼吸ケア・リハ学会誌 Volume: 21 Pages: 138-141
  • NAID: 130005164140
  • URL: http://www.jsrcr.jp/
• [Journal Article] Activation of the prefrontal cortex is associated with exertional dyspnea in chronic obstructive pulmonary disease. (2011)
  • Author(s): Higashimoto Y
  • Journal Title: Respiration Volume: 82 Pages: 492-500
  • URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21474913
  • Peer Reviewed
• [Journal Article] Clinical and inflammatory factors associated with body mass index in elderly patients with chronic obstructive pulmonary disease. (2011)
  • Author(s): Higashimoto Y
  • Journal Title: Geriatr Gerontol Int Volume: 11 Pages: 32-38
  • NAID: 10027913481
  • URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20609004
  • Peer Reviewed
• [Presentation] Localization Of Brain Activation Associated With Dyspnea During Exercise With Respiratory Resistance : A Study Using BOLD fMRI, [Publication Page : A4907] (2013)
  • Author(s): N. Honda, Y. Higashimoto, R. Okada, M. Onoda, K. Maeda, M. Shiraishi, R. Sugiya, S. Okajima, T. Yamagata, K. Terada, Y. Tohda, K. Fukuda
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia, Pennsylvania, USA
  • Year and Date: 2013-05-21
• [Presentation] Changes In Physical Activity After Lung Resection For Lung Cancer And Postoperative Pulmonary Rehabilitation, [Publication Page : A1806] (2013)
  • Author(s): K. Maeda, , Y. Higashimoto, , N. Honda,, M. Shiraishi, T. Hirohata, K. Minami, T. Iwasaki, T. Yamagata, K. Terada, Y. Matsuo, Y. Tohda, K. Fukuda
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia, Pennsylvania, USA
  • Year and Date: 2013-05-19
• [Presentation] Involvement Of G Proteins In The Synergistic Effects Between Anticholinergic Agents And Beta2-Adrenoceptor Agonists In Airway Smooth Muscle, [Publication Page : A1996] (2013)
  • Author(s): H. Kume, S. Imbe, O. Nishiyama, T. Iwanaga, Y. Higashimoto, H. Nakajima, Y. Tohda
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia, Pennsylvania, USA
  • Year and Date: 2013-05-19
• [Presentation] Changes In Physical Activity After Lung Resection For Lung Cancer And Postoperative Pulmonary Rehabilitation, (2013)
  • Author(s): K Maeda, Y Higashimoto, N Honda, M Shiraishi, T Hirohata, K Minami, T Iwasaki, T Yamagata, K Terada, Y Matsuo, Y Tohda, K Fukuda
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Philadelphia, USA
• [Presentation] Prefrontal Cortex Activation Is Associated With Dyspnea During Methacholine Bronchial Provocation Tests, (2013)
  • Author(s): Y Higashimoto, N Okimoto, N Honda, T Yamagata, R Yamazaki, Y Fukai, S Innbe, H Miyajima, H Santoh, A Sano, Y Makino, R Satoh, O Nishiyama, H Sano, T Iwanaga, H Nakajima, H Kume, Y Tohda
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Philadelphia, USA
• [Presentation] Localization Of Brain Activation Associated With Dyspnea During Exercise With Respiratory Resistance: A Study Using BOLD fMRI, (2013)
  • Author(s): N Honda, Y Higashimoto, R Okada, M Onoda, K Maeda, M Shiraishi, R Sugiya, S Okajima, T Yamagata, K Terada, Y Tohda, K Fukuda
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Philadelphia, USA
• [Presentation] Involvement Of G Proteins In The Synergistic Effects Between Anticholinergic Agents And Beta2-Adrenoceptor Agonists In Airway Smooth Muscle, (2013)
  • Author(s): H Kume, S Imbe, O Nishiyama, T Iwanaga, Y Higashimoto, H Nakajima, Y Tohda
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: iladelphia, USA
• [Presentation] Effect Of Protcaterol "Assist Use" On Quality Of Life And Exercise Capacity In Patients With Chronic Obstructive Pulmonary Disease, [Publication Page : A5792] (2012)
  • Author(s): Y. Higashimoto, H. Miyajima, H. Ichihashi, A. Sano, R. Satoh, O. Nishiyama, H. Sano, T. Yamagata, T. Iwanaga, H. Nakajima, K. Tomita, , H. Kume
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco, California, USA
  • Year and Date: 2012-05-23
• [Presentation] Cerebral Oxygenation During Exercise In COPD Patients With And Without Exertional Desaturation, [Publication Page : A6399] (2012)
  • Author(s): Y. Higashimoto, N. Honda, T. Yamagata, O. Nishiyama, H. Miyajima, A. Sano, H. Ichihashi, R. Satoh, H. Sano, T. Iwanaga, H. Nakajima, K. Tomita, H. Kume, Y. Tohda
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco, California, USA
  • Year and Date: 2012-05-23
• [Presentation] Decreased Cortical Activation In COPD Patients During Exercise, [Publication Page : A3991] (2012)
  • Author(s): N. Honda, Y. Higashimoto, K. Maeda, K. Fukuda, Y. Tohda
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco, California, USA
  • Year and Date: 2012-05-22
• [Presentation] Prefrontal Cortex Activation Is Associated With Dyspnea During Methacholine Bronchial Provocation Tests, [Publication Page : A4105] (2012)
  • Author(s): Y. Higashimoto, N. Okimoto, N. Honda, T. Yamagata, R. Yamazaki, Y. Fukai, S. Innbe, H. Miyajima, H. Santoh, A. Sano, Y. Makino, R. Satoh, O. Nishiyama, H. Sano, T. Iwanaga, H. Nakajima, H. Kume, Y
  • Organizer: Tohda American Thoracic Society International Conference
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia, Pennsylvania, USA
  • Year and Date: 2012-05-21
• [Presentation] アレルギー疾患におけるバイオマーカーの最新情報－成人領域 (2012)
  • Author(s): 東本有司、東田有智
  • Organizer: 第62回 日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Cerebral Oxygenation During Exercise In COPD Patients With And Without Exertional Desaturation. (2012)
  • Author(s): Higashimoto Y, Honda N, Yamagata T,Nishiyama O, Miyajima H, Sano A, Ichihashi H, Satoh R, Sano H, Iwanaga T, Nakajima H, Tomita K, Kume H, Tohda Y
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: アメリカ合衆国 サンフランシスコ
• [Presentation] Effect Of Protcaterol "Assist Use" On Quality Of Life And Exercise Capacity In Patients With Chronic Obstructive Pulmonary Disease. (2012)
  • Author(s): 49. Higashimoto Y, Miyajima H, Ichihashi H, Sano A, Satoh R,Nishiyama O, Sano H, Yamagata T, Iwanaga T, Nakajima H, Tomita K, Kume H, Tohda
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: アメリカ合衆国 サンフランシスコ
• [Presentation] 高齢COPD患者の労作時脳皮質酸素化 (2012)
  • Author(s): 東本有司
  • Organizer: 日本老年医学会年次学術講演会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 運動時低酸素をきたすcopd患者の運動時脳皮質酸素化ヘモグロビン濃度の観察 (2012)
  • Author(s): 東本 有司, 山縣 俊之, 西山 理, 宮嶋 宏之, 市橋 秀夫, 佐野 安希子, 佐藤 隆司, 佐野 博幸, 岩永 賢司, 中島 宏和, 冨田 桂公, 久米 裕昭, 東田 有智
  • Organizer: 日本呼吸器学会学術講演会
  • Place of Presentation: 神戸国際会議場
• [Presentation] 特発性間質性肺炎患者の労作時呼吸困難と関連する脳皮質領域の検索 (2012)
  • Author(s): 東本 有司, 本田 憲胤, 沖本 奈美, 前田 和成, 西山 理, 山縣 俊之, 中島 宏和, 久米 裕昭, 福田 寛二, 東田 有智
  • Organizer: 日本呼吸ケア・リハビリテーション学会学術集会
  • Place of Presentation: 福井県 福井フェニックス・プラザ
• [Presentation] 運動時低酸素をきたすCOPD患者の脳皮質酸素化ヘモグロビン濃度 (2012)
  • Author(s): 東本有司
  • Organizer: 第4回 呼吸機能イメージング研究会学術集会
  • Place of Presentation: 滋賀県大津市ピアザ淡海 滋賀県立県民交流センター
• [Presentation] 慢性閉塞性肺疾患の労作時呼吸困難と前頭葉皮質脳活動との関係 (2011)
  • Author(s): 東本有司
  • Organizer: 日本光脳機能イメージング研究会
  • Place of Presentation: 東京都千代田区星陵会館
• [Presentation] 高齢慢性閉塞性肺疾患患者の呼吸リハビリテーションとその問題点 (2011)
  • Author(s): 東本有司
  • Organizer: 第79回和歌山医学会総会(招待講演)
  • Place of Presentation: 和歌山市和歌山県立医科大学
• [Presentation] 運動時低酸素をきたすＣＯＰＤ患者脳皮質酸素化ヘモグロビン濃度の観察 (2011)
  • Author(s): 東本有司
  • Organizer: 第21回日本呼吸ケア・リハビリテーション学会学術集会
  • Place of Presentation: 長野県松本文化会館
• [Book] 包括的呼吸リハビリテーションポケットマニュアル (2013)
  • Author(s): 東本有司他31名、上月正博、海老原覚編
  • Total Pages: 264
  • Publisher: 診断と治療社
• [Book] 包括的呼吸リハビリテーションポケットマニュアル (2013)
  • Author(s): 上月正博、海老原覚、東本有司、渡邉裕志、髙橋純子，矢内 勝、三塚由佳、矢満田慎介、平井豊博、戸田正夫、石川悠加、須藤英一、飯島弘晃、浅田成紀、岡崎達馬、中村 豊、柏崎尚大、山縣俊之、後藤葉子、國枝顕二郎、他21名
  • Total Pages: 264
  • Publisher: 診断と治療社
• [Book] プライマリケアのための喘息治療―外来マネジメント (2011)
  • Author(s): 東本有司、東田有智、久米裕昭、佐野博幸、村木正人、岩永賢司、冨田桂公、市橋秀夫、佐藤隆司、牧野靖、佐野安希子、山片重良、中島宏和、西山理、宮良高維編
  • Publisher: 医療ジャーナル社