Establishment of iPS cells derived from the patients with Kii ALS/PDC and proliferation from iPS cells to neuronal cells

• Project/Area Number: 23591242
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Mie University
• Principal Investigator: KOKUBO YASUMASA 三重大学, 地域イノベーション学研究科, 招へい教授 (60263000)
• Co-Investigator(Kenkyū-buntansha): KUZUHARA Sigeki 鈴鹿医療科学大学, 保健衛生学部, 教授 (70111383) ; HIROKAWA Yoshifumi 三重大学, 大学院医学系研究科, 講師 (30322738)
• Co-Investigator(Renkei-kenkyūsha): ERA Takumi 熊本大学, 発生医学研究所, 教授 (00273706)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 紀伊半島 / ALS/PDC / iPS細胞 / 神経変性疾患 / 筋萎縮性側索硬化症 / パーキンソン認知症複合 / グアム島 / タウオパチー / TDP-43 / αシヌクレイン / 難病 / α-シヌクレイン

Research Abstract

Disease-specific iPS cells have been established from T cells derived from the five patients with Kii ALS/PDC. The efficiency of establishment and speed of proliferation were different among cases. We are going to select iPSC clones for differentiation to neuronal cells and glia cells, and analyze them to reveal pathology and create a new treatment for Kii ALS/PDC.

Research Products

• [Journal Article] Cerebrospinal Fluid Biomarkers for Kii Amyotrophic Lateral Sclerosis /Parkinsonism-Dementia Complex (2013)
  • Author(s): Yui Nakayama, Satoru Morimoto, Misao Yoneda, Shigeki Kuzuhara, and Yasumasa Kokubo
  • Journal Title: Journal of Neurodegenerative Diseases Volume: Article ID 679089 Pages: 4-4
  • Peer Reviewed
• [Journal Article] Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS (2013)
  • Author(s): Kotaro Ogaki,Yuanzhe Li,Masashi Takanashi,Kei-Ichi Ishikawa,Tomonori Kobayashi,Takashi Nonaka,Masato Hasegawa, Masahiko Kishi,Hiroyo Yoshino,Manabu Funayama,Tetsuro Tsukamoto,Keiichi Shioya, Masayuki Yokochi,Hisamasa Imai,Ryogen Sasaki,Yasumasa Kokubo,Shigeki Kuzuhara,Hiroyuki Tomiyama,,Nobutaka Hattori
  • Journal Title: Parkinsonism Relat Disord Volume: 19(1) Pages: 15-20
  • Peer Reviewed
• [Journal Article] Environmental Characteristics and oidative stress of inhabitants and patinets with amyoyrophic lateral sclerosis in a high-incidence area on the Kii peninsula, Japan (2013)
  • Author(s): Tameko Kihira, Kazushi Okamoto, Sohei Yoshida, Tetuya Kondo, Keiko Iwai, Sachiko Wada, Yoshinori Kajimoto, Tomoyoshi Kondo, Yasumasa Kokubo, Shigeki Kuzuhara
  • Journal Title: Internal Medicine Volume: 52 Pages: 1479-1486
  • Peer Reviewed
• [Journal Article] Rare case of disseminated cysticercosis and taeniasis in a Japanese traveller after returning from India (2013)
  • Author(s): Ken-ichiro Kobayashi, Fukumi Nakamura-Uchiyama, Takeshi Nishiguchi, Kenichi Isoda, Yasumasa Kokubo, Katsuhiko Ando, Masaki Katurahara, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Sentaro Iwabuchi, and Kenji Ohnishi
  • Journal Title: Am J Trop Med Hyg Volume: 89(1) Pages: 58-62
  • Peer Reviewed
• [Journal Article] Cerebrospinal Fluid Biomarkers for Kii Amyotrophic Lateral Sclerosis /Parkinsonism-Dementia Complex. (2013)
  • Author(s): Yui Nakayama, Satoru Morimoto, Misao Yoneda, Shigeki Kuzuhara, and Yasumasa Kokubo.
  • Journal Title: Journal of Neurodegenerative Diseases. Volume: 2013 Pages: 1-4
  • DOI: 10.1155/2013/679089
  • Peer Reviewed
• [Journal Article] Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS. (2013)
  • Author(s): Kotaro Ogaki,Yuanzhe Li,Masashi Takanashi,Kei-Ichi Ishikawa,Tomonori Kobayashi,Takashi Nonaka,Masato Hasegawa, Masahiko Kishi,Hiroyo Yoshino,Manabu Funayama,Tetsuro Tsukamoto,Keiichi Shioya, Masayuki Yokochi,Hisamasa Imai,Ryogen Sasaki,Yasumasa Kokubo,Shigeki Kuzuhara,Hiroyuki Tomiyama,,Nobutaka Hattori.
  • Journal Title: Parkinsonism Relat Disord. Volume: 19 Pages: 15-20
  • Peer Reviewed
• [Journal Article] Environmental Characteristics and oidative stress of inhabitants and patinets with amyoyrophic lateral sclerosis in a high-incidence area on the Kii peninsula, Japan. (2013)
  • Author(s): Tameko Kihira, Kazushi Okamoto, Sohei Yoshida, Tetuya Kondo, Keiko Iwai, Sachiko Wada, Yoshinori Kajimoto, Tomoyoshi Kondo, Yasumasa Kokubo, Shigeki Kuzuhara.
  • Journal Title: Internal Medicine Volume: 52 Pages: 1479-1486
  • Peer Reviewed
• [Journal Article] Rare case of disseminated cysticercosis and taeniasis in a Japanese traveller after returning from India. (2013)
  • Author(s): Ken-ichiro Kobayashi, Fukumi Nakamura-Uchiyama, Takeshi Nishiguchi, Kenichi Isoda, Yasumasa Kokubo, Katsuhiko Ando, Masaki Katurahara, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Sentaro Iwabuchi, and Kenji Ohnishi.
  • Journal Title: Am J Trop Med Hyg. Volume: 89 Pages: 58-62
  • Peer Reviewed
• [Journal Article] α-Synuclein Pathology in Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex in the Kii Peninsula, Japan (2012)
  • Author(s): Kokubo Y, Taniguchi A, Hasegawa M, Hayakawa Y, Morimoto S, Yoneda M, Hirokawa Y, Shiraishi T, Saito Y, Murayama S, Kuzuhara S
  • Journal Title: J Neuropathol Exp Neurol Volume: 71 Pages: 625-630
  • Peer Reviewed
• [Journal Article] Cardiac (123)I-meta-iodobenzylguanidine scintigraphy in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula, Japan (2012)
  • Author(s): Kokubo Y, Nomura Y, Morimoto S, Kuzuhara S
  • Journal Title: Parkinsonism and Related Disorders Volume: 18 Pages: 306-308
  • Peer Reviewed
• [Journal Article] Mutational analysis of familial and sporadic amyotrophic lateral sclerosis with OPTN mutations in Japanese population (2012)
  • Author(s): Naruse H, Takahashi Y, Kihira T, Yoshid S, Kokubo Y, Kuzuhara S, Ishiura H, Amagasa M, Murayama S, Tsuji S, Goto J
  • Journal Title: Amyotroph Lateral Scler Volume: 13 Pages: 562-566
  • Peer Reviewed
• [Journal Article] An increase in ALS incidence on the Kii Peninsula, 1960-2009: A possible link to change in drinking water source (2012)
  • Author(s): Tameko Kihira, S Yoshida, T Kondo, K Iwai, S Wada, S Morinaga, Y Kazimoto, T Kondo, K Okamoto, Y Kokubo, S Kuzuhara
  • Journal Title: Amyotrophic Lateral Sclerosis Volume: 13 Pages: 347-350
  • Peer Reviewed
• [Journal Article] Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex in the Kii Peninsula of Japan (Muro disease): a review w on recent research and new concept (2012)
  • Author(s): Kuzuhara S, Kokubo Y
  • Journal Title: Amyotrophic Lateral Sclerosis and the frontotemporal dementias(Oxford University Press, Ed. By Michael J. Strong) Pages: 39-54
  • Peer Reviewed
• [Journal Article] α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula, Japan (2012)
  • Author(s): Kokubo Y, Hirokawa Y, Shiraishi T, Kuzuhara S.ほか
  • Journal Title: J Neuropathol Exp Neurol Volume: 71(7) Pages: 625-630
  • Peer Reviewed
• [Journal Article] Cardiac (123)I-meta-iodobenzylguanidine scintigraphy in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula, Japan. (2012)
  • Author(s): Kokubo Y, Nomura Y, Morimoto S, Kuzuhara S.
  • Journal Title: Parkinsonism and Related Disorders Volume: 18 Pages: 306-308
  • Peer Reviewed
• [Journal Article] α-Synuclein Pathology in the Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex in the Kii Peninsula, Japan. (2012)
  • Author(s): Kokubo Y, Taniguchi A, Hasegawa M, Hayakawa Y, Morimoto S, Yoneda M, Hirokawa Y, Shiraishi T, Saito Y, Murayama S, Kuzuhara S.
  • Journal Title: J Neuropathol Exp Neurol. Volume: 71 Pages: 625-630
  • Peer Reviewed
• [Journal Article] Cardiac 123I-Meta- Iodobenzylguanidine Scintigraphy and Lewy Body Pathology in a Patient with Amyotrophic Lateral Sclerosis and Parkinsonism–Dementia Complex of Kii, Japan (2011)
  • Author(s): Kokubo Y, Morimoto S, Shindo A, Hirokawa Y, Shiraishi T, Saito Y, Murayama S, Kuzuhara S
  • Journal Title: Mov Disord Volume: 26 Pages: 401-403
  • Peer Reviewed
• [Journal Article] PLA2G6 variant in Parkinson's disease (2011)
  • Author(s): Hiroyuki Tomiyama, Hiroyo Yoshino, Kotaro Ogaki, Lin Li, Chikara Yamashita, Yuanzhe Li, Manabu Funayama, Ryogen Sasaki, Yasumasa Kokubo, Shigeki Kuzuhara, and Nobutaka Hattori
  • Journal Title: J Hum Genet Volume: 56(5) Pages: 401-403
  • NAID: 10030659472
  • Peer Reviewed
• [Journal Article] Cardiac 123I-Meta- Iodobenzylguanidine Scintigraphy and Lewy Body Pathology in a Patient with Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex of Kii, Japan (2011)
  • Author(s): Yasumasa Kokubo, Satoru Morimoto, Akihiro Shindo, Yoshihumi Hirokawa, Taizo Shiraishi, Yuko Saito, Shigeo Murayama, Shigeki Kuzuhara
  • Journal Title: J Hum Genet. Volume: Oct;26(12) Pages: 2300-2301
  • Peer Reviewed
• [Journal Article] PLA2G6 variant in Parkinson’s disease (2011)
  • Author(s): Hiroyuki Tomiyama, Hiroyo Yoshino, Kotaro Ogaki, Lin Li, Chikara Yamashita, Yuanzhe Li, Manabu Funayama, Ryogen Sasaki, Yasumasa Kokubo, Shigeki Kuzuhara, and Nobutaka Hattori
  • Journal Title: Mov Disord. Volume: May;56(5) Pages: 401-403
  • NAID: 10030659472
  • Peer Reviewed
• [Presentation] Clinical trial of Edaravone in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula of Japan (2013)
  • Author(s): Y. Kokubo, S. Morimoto, T. Nakagawa, K. Miyazaki, S. Kuzuhara
  • Organizer: 24th International Symposium on ALS/MND
  • Place of Presentation: Milan,Italy
• [Presentation] Transitional metal contents in scalp hair and lifestyle of ALS patients and residents in the Kii Peninsula, Japan -the second report- (2013)
  • Author(s): Tameko Kihira, Iori Sakurai, Sohei Yoshida, Ikuro Wakayama, Koichi Takamiya, Yukihiro Nakano, Ryo Okumura, Iinuma Yuhto, Keiko Iwai, Junko Kohmoto, Yoshinori Kajimoto, Yasuhiro Hiwatani, Kazushi Okamoto, Yasumasa Kokubo, Shigeki Kuzuhara
  • Organizer: 24th International Symposium on ALS/MND
  • Place of Presentation: Milan,Italy
• [Presentation] Immunohistochemical study of the cerebellum in amyotrophic lateral screlosis (ALS)/ parkinson-dementia complex (PDC) in Kii peninsula (ALS/PDC- Kii, Muro disease) (2013)
  • Author(s): Satoru Morimoto, Yasumasa Kokubo , Hiroyuki Hatsuta, Shigeki Kuzuhara, Shigeo Murayama
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: Boston, USA
• [Presentation] Amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan (Muro disease). - Recent Advances of Reserch - (2013)
  • Author(s): Yasumasa Kokubo
  • Organizer: 9th international congress on mental disorders & other non-motor features in Parkinson's diseaseand related disorders. MDPD 2013. in Seoul
  • Place of Presentation: South Korea
• [Presentation] Clinical trial of Edaravone in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula of Japan. (2013)
  • Author(s): Y. Kokubo, S. Morimoto, T. Nakagawa, K. Miyazaki, S. Kuzuhara.
  • Organizer: 24th International Symposium on ALS/MND.
  • Place of Presentation: イタリア、ミラノ
• [Presentation] Transitional metal contents in scalp hair and lifestyle of ALS patients and residents in the Kii Peninsula, Japan -the second report-. (2013)
  • Author(s): Tameko Kihira, Iori Sakurai, Sohei Yoshida, Ikuro Wakayama, Koichi Takamiya, Yukihiro Nakano, Ryo Okumura, Iinuma Yuhto, Keiko Iwai, Junko Kohmoto, Yoshinori Kajimoto, Yasuhiro Hiwatani, Kazushi Okamoto, Yasumasa Kokubo, Shigeki Kuzuhara.
  • Organizer: 24th International Symposium on ALS/MND.
  • Place of Presentation: イタリア、ミラノ
• [Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合における脳脊髄液中酸化ストレスの解析 (2013)
  • Author(s): 小久保康昌、江口 聡、福持皓介、森本 悟、葛原茂樹
  • Organizer: 第32回日本認知症学会
  • Place of Presentation: 松本
• [Presentation] Immunohistochemical study of the cerebellum in amyotrophic lateral screlosis (ALS)/ parkinson-dementia complex (PDC) in Kii peninsula (ALS/PDC- Kii, Muro disease) (2013)
  • Author(s): Satoru Morimoto, Yasumasa Kokubo , Hiroyuki Hatsuta, Shigeki Kuzuhara, Shigeo Murayama
  • Organizer: Alzheimer's Association International Conference, 2013
  • Place of Presentation: 米国、ボストン
• [Presentation] 西ニューギニア地域における神経変性疾患の実態に関する縦断的研究 (2013)
  • Author(s): 奥宮清人、松林公蔵、和田泰三、藤澤道子、小久保康昌 、葛原茂樹、平田温 、大崎康史、坂本
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 日本人パーキンソン病におけるVPS35 D620N変異の同定 (2013)
  • Author(s): 舩山学、安藤真矢、李元哲、柏原健一、村上善勇、石津暢隆、豊田千純子、野口克彦、橋本貴司、中野直樹、佐々木良元、小久保康昌、葛原茂樹、大垣光太郎、山下力、吉野浩代、波田野琢、富山弘幸、服部信孝
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 紀伊半島南部ALS多発地域における生活習慣の変化に関する検討 (2013)
  • Author(s): 紀平 為子、岡本和士、吉田宗平、江上いすず、岩井恵子、和田幸子、小久保康昌、葛原茂樹
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] Kii ALS/PDC における小脳の免疫組織化学的検討 (2013)
  • Author(s): 森本 悟、初田 裕幸、小久保 康昌、葛原 茂樹、村山 繁雄
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 紀伊半島の牟婁病(Kii ALS/PDC) における脳内 BMAA の解析 (2013)
  • Author(s): 小久保康昌、 Sandra Banack、森本 悟、村山繁雄、富樫辰也、 Walter G. Bradley、 Paul Alan Cox、葛原茂樹
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合 (Kii ALS/PDC、牟婁病)における小脳の免疫組織化学的検討 (2013)
  • Author(s): 森本 悟、初田 裕幸、小久保 康昌、葛原 茂樹、村山 繁雄
  • Organizer: 第54回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京 西船堀
• [Presentation] パーキンソニズムで発症し、PDDとの鑑別を要した紀伊PDCの1例 (2013)
  • Author(s): 小久保 康昌、森本 悟、米田操、広川佳史、白石泰三、長谷川成人、村山 繁雄、葛原 茂樹
  • Organizer: 第54回日本神経病理学会総会学術研究会
  • Place of Presentation: 東京 西船堀
• [Presentation] Amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan (Muro disease). - Recent Advances of Reserch - (2013)
  • Author(s): Yasumasa Kokubo
  • Organizer: 9th international congress on mental disorders & other non-motor features in Parkinson's disease and related disorders. MDPD 2013
  • Place of Presentation: Seoul. South Korea.
• [Presentation] Alfa-Synuclein pathology of amyotrophic lateral sclerosis/parkinsonism-dementia complex in the Kii Peninsula, Japan (2012)
  • Author(s): Yasumasa Kokubo, Akira Taniguchi, Masato Hasegawa, Yuma Hayakawa, Satoru Morimoto, Misao Yoneda, Yoshihumi Hirokawa, Taizo Shiraishi, Yuko Saito, Shigeo Murayama, Shigeki Kuzuhara
  • Organizer: The 8^<th> International Conference on Frontotemporal dementias
  • Place of Presentation: Manchester, UK
• [Presentation] Immunochemical Study Western blotting of tauopathy in ALS/ Parkinson Dementia Complex (PDC), Kii ,Japan (2012)
  • Author(s): Satoru Morimoto,Yasumasa Kokubo, Masato Hasegawa, Shigeki Kuzuhara,Shigeo Murayama
  • Organizer: AANP
  • Place of Presentation: Chicago, USA
• [Presentation] Changing patterns of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) of the Kii peninsula in Japan (2012)
  • Author(s): Shigeki Kuzuhara、Yasumasa Kokubo
  • Organizer: 13th Asian Oceanian Congress of Neurology
  • Place of Presentation: Melbourne, Australia
• [Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合（牟婁病：KiiALS/PDC)ー現状と課題ー (2012)
  • Author(s): 小久保康昌
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 13th Asian Oceanian Congress of Neurology (2012)
  • Author(s): Shigeki Kuzuhara、 Yasumasa Kokubo
  • Organizer: Changing patterns of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) of the Kii peninsula in Japan
  • Place of Presentation: オーストラリア、メルボルン
• [Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合患者におけるedaravon投与の効果 (2012)
  • Author(s): 小久保康昌、森本悟、中川、宮崎光一、葛原茂樹
  • Organizer: 第30回 神経医治療学会総会
  • Place of Presentation: 北九州国際会議場
• [Presentation] Alfa-Synuclein pathology of amyotrophic lateral sclerosis/parkinsonism-dementia complex in the Kii Peninsula, Japan (2012)
  • Author(s): Yasumasa Kokubo , Akira Taniguchi, Masato Hasegawa, Yuma Hayakawa, Satoru Morimoto, Misao Yoneda , Yoshihumi Hirokawa , Taizo Shiraishi , Yuko Saito , Shigeo Murayama , Shigeki Kuzuhara
  • Organizer: 8th International Conference on Frontotemporal Dementias
  • Place of Presentation: Manchester, UK
• [Presentation] NEUROPSYCHOLOGICAL STUDY OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS/PARKINSONISM-DEMENTIA COMPLEX OF THE KII PENINSULA OF JAPAN (2011)
  • Author(s): SHINDO A,KUZUHARA S,KOKUBO Y
  • Organizer: 22th International Symposium on ALS/MND
  • Place of Presentation: Sydoney,Australia
• [Presentation] PREDICTORS OF INCREASE IN SEVERITY AMONG JAPANESE AMYOTROPHIC LATERAL SCLERROSIS PATIENTS BY DISCRIMINANT ANALYSIS (2011)
  • Author(s): OKAMOTO K,KIHIRA T,KUZUHARA S,KOKUBO Y
  • Organizer: 22th International Symposium on ALS/MND
  • Place of Presentation: Sydney,Australia
• [Presentation] NEUROPSYCHOLOGICAL STUDY OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS/PARKINSONISM-DEMENTIA COMPLEX OF THE KII PENINSULA OF JAPAN (2011)
  • Author(s): SHINDO A,KUZUHARA S,KOKUBO Y
  • Organizer: 22th International Symposium on ALS/MND
  • Place of Presentation: Sydney,Australia
• [Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合におけるバイオマーカーの検討ー脳脊髄液中タウ, リン酸タウ,Aβの解析ー (2011)
  • Author(s): 小久保康昌、中山由衣、森本悟、葛原茂樹
  • Organizer: 第30回日本認知症学会
  • Place of Presentation: タワーホール船堀
• [Presentation] パーキンソン病におけるPLA2G6変異の意義 (2011)
  • Author(s): 吉野浩代、富山弘幸、大垣光太郎、李林、李元哲、舩山学、佐々木良元、小久保康昌、葛原茂樹、服部信孝
  • Organizer: 第56回日本人類遺伝学会大会
  • Place of Presentation: 千葉幕張メッセ
• [Presentation] 紀伊半島のALS/PDCにおけるバイオマーカーの検討 - 脳脊髄液中タウ、リン酸化タウ、Aβの解析 - (2011)
  • Author(s): 小久保康昌、中山由衣、森本悟、葛原茂樹
  • Organizer: 第5回MDSJコングレス
  • Place of Presentation: 品川プリンスホテル
• [Presentation] パーキンソン病におけるPLA2G6変異の意義 (2011)
  • Author(s): 吉野浩代、富山弘幸、大垣光太郎、李林、李元哲、舩山学、佐々木良元、小久保康昌、葛原茂樹、服部信孝
  • Organizer: 第5回MDSJコングレス
  • Place of Presentation: 品川プリンスホテル
• [Presentation] FTDP-17が疑われた日本人患者75症例におけるPGRNとMAPT 遺伝子解析 (2011)
  • Author(s): 大垣光太郎、李元哲、高梨雅史、石川景一、小林智則、中西淳、野中隆、長谷川成人、岸 雅彦、吉野浩代、舩山学、塩屋敬一、横地正之、佐々木良元、小久保康昌、葛原茂樹、本井ゆみ子、富山弘幸、服部信孝
  • Organizer: 第5回MDSJコングレス
  • Place of Presentation: 品川プリンスホテル
• [Presentation] PLA2G6 in patients with Parkinson’s disease / frontotemporal type of dementia (2011)
  • Author(s): H. Tomiyama, H. Yoshino, K. Ogaki, L. Li, C. Yamashit1, Y. Li, M. Funayama, R. Sasaki, Y. Kokubo, S. Kuzuhara, and N. Hattori
  • Organizer: 国際人類遺伝学会議（ICHG2011）／米国人類遺伝学会（ASHG）大会
  • Place of Presentation: カナダ・モントリオール
• [Presentation] Research Consortium of Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of the Kii Peninsula of Japan (2011)
  • Author(s): . Kokubo,S.Murayama, H. Tomiyama,Y.Hirokawa,M.Hasegawa,K.Okamoto,T.Kihira,A.Takashima,S.Tsuji,S.Kuzuhara
  • Organizer: ICAD 2011
  • Place of Presentation: Paris,France
• [Presentation] 人工呼吸器装着するも、経口摂取で13年生存した紀伊ALSの1例 (2011)
  • Author(s): 小久保康昌、森本悟、村山繁雄、葛原茂樹
  • Organizer: 第52回日本神経病理学会
  • Place of Presentation: 京都
• [Presentation] パーキンソン病におけるPLA2G6変異の意義 (2011)
  • Author(s): 吉野浩代、富山弘幸、大垣光太郎、李林、李元哲、舩山学、佐々木良元、小久保康昌、葛原茂樹、服部信孝
  • Organizer: 第52回 日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] 筋萎縮性側索硬化症発症関連要因解明に関する症例対照研究 (2011)
  • Author(s): 岡本和士、 紀平為子、 小久保康昌、葛原茂樹、 江上いすず、永井正規
  • Organizer: 第52回 日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] FTDP-17が疑われた日本人75症例におけるPGRNとMAPT 遺伝子解析 (2011)
  • Author(s): 大垣光太郎、李元哲、高梨雅史、石川景一、小林智則、中西淳、野中隆、長谷川成人、岸 雅彦、吉野浩代、舩山学、塩屋敬一、横地正之、佐々木良元、小久保康昌、葛原茂樹、本井ゆみ子、富山弘幸、服部信孝
  • Organizer: 第52回 日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] 大島地区でのALS疫学的調査―第１報- (2011)
  • Author(s): 紀平為子、吉田宗平、岡本和士、梶本賀義、近藤智善、小久保康昌、葛原茂樹
  • Organizer: 第52回 日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Book] Amyotrophic lateral sclerosis-parkinsonism-dementia complex in the Kii peninsula of Japan(Muro disease):a review on recent research and new concept (2012)
  • Author(s): Shigeki Kuzuhara, Yasumasa Kokubo.et.
  • Publisher: Oxford University Press
• [Book] Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias (2012)
  • Author(s): Shigeki Kuzuhara, Yasumasa Kokubo
  • Total Pages: 407
  • Publisher: Oxford University Press
• [Remarks] 紀伊半島の筋萎縮性総索硬化症/パーキンソン認知症複合-Kii ALS/PDC-
  • URL: http://kii-als-pdc-project.com
• [Remarks] 紀伊半島の筋萎縮性総索硬化症/パーキンソン認知症複合 -Kii ALS/PDC-
  • URL: http://kii-als-pdc-project.com
• [Remarks]
  • URL: http://square.umin.ac.jp/ALS-PDC/access.html