Dynamics of brain functional connectivity associated with alternation of consciousness
Project/Area Number |
23591273
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Kyoto University |
Principal Investigator |
MATSUMOTO Riki 京都大学, 医学(系)研究科(研究院), 准教授 (00378754)
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Co-Investigator(Kenkyū-buntansha) |
池田 昭夫 京都大学, 医学研究科, 教授 (90212761)
國枝 武治 京都大学, 医学研究科, 講師 (60609931)
澤本 伸克 京都大学, 医学研究科, 講師 (90397547)
松橋 眞生 京都大学, 脳機能総合センター (40456885)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 機能的結合 / 皮質間ネットワーク / 意識変容 / てんかん / 睡眠 / 皮質皮質間誘発電位 / 脳波機能的MRI同時計測 / デフォルト・モード・ネットワーク / 高周波律動 / 脳波機能的MRI同時計測 / 安静時機能的MRI |
Research Abstract |
Despite its significance in clinical neuroscience, the dynamic alternation of brain networks associated with alternation of consciousness still remains elusive. By means of invasive (cortico-cortical evoked potential: CCEP) and non-invasive (simultaneous recording of EEG and fMRI: EEGfMRI) methods that probe the brain connectivity or network, we investigated sleep, namely, physiological alternation of consciousness, and epileptic encephalopathy, a model of pathological chronic alternation of consciousness, respectively. The CCEP study revealed that cortico-cortical connectivity/excitability dynamically modulated as the sleep stage changed and its degree differed among lobes. EEGfMRI in patients with hypothalamic hamartoma (a model disease of epileptic encephalopathy) revealed that epileptic spikes decreased neural activities in the default mode network (DMN). Chronic exposure to spikes resulted in impairment of DMN and likely led to epileptic encephalopathy.
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Report
(4 results)
Research Products
(121 results)
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[Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation.2014
Author(s)
Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S.
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Journal Title
Hum Brain Mapp
Volume: 印刷中
Issue: 9
Pages: 74-85
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Evaluation of Focus Laterality in Temporal Lobe Epilepsy: A Quantitative Study Comparing Double Inversion-Recovery MR Imaging at 3T with FDG-PET.2013
Author(s)
Morimoto E, Okada T, Kanagaki M, Yamamoto A, Fushimi Y, Matsumoto R, Takaya S, Ikeda A, Kunieda T, Kikuchi T, Paul D, Miyamoto S, Takahashi R, Togashi K.
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Journal Title
Epilepsia
Volume: 54
Issue: 12
Pages: 2174-83
DOI
Related Report
Peer Reviewed
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[Journal Article] Pre-SMA actively engages in conflict processing in human: a combined study of epicortical ERPs and direct cortical stimulation.2013
Author(s)
Usami, K., Matsumoto, R., Kunieda, T., Shimotake, A., Matsuhashi, M., Miyamoto, S., Fukuyama, H., Takahashi, R., & Ikeda, A.
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Journal Title
Neuropsychologia
Volume: 51
Issue: 5
Pages: 1011-1017
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Bereitschaftspotential augmentation by neuro-feedback training in Parkinson's disease.2013
Author(s)
Fumuro T, Matsuhashi M, Mitsueda T, Inouchi M, Hitomi T, Nakagawa T, Matsumoto R, Kawamata J, Inoue H, Mima T, Takahashi R, Ikeda A.
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Journal Title
Clin Neurophysiol
Volume: 124
Issue: 7
Pages: 1388-405
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Internal structural changes in the hippocampus observed on 3-Tesla MRI in patients with mesial temporal lobe epilepsy2013
Author(s)
Mitsueda-Ono T, Ikeda A, Sawamoto N, Aso T, Hanakawa T, Kinoshita M, Matsumoto R, Mikuni N, Amano S, Fukuyama H, Takahashi R
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Journal Title
Int ernal Medicine
Volume: 52(Epub 2013 Apr 15)
Pages: 877-885
NAID
Related Report
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[Journal Article] Internal structural changes in the hippocampus observed on 3-Tesla MRI in patients with mesial temporal lobe epilepsy.2013
Author(s)
Mitsueda-Ono T, Ikeda A, Sawamoto N, Aso T, Hanakawa T, Kinoshita M, Matsumoto R, Mikuni N, Amano S, Fukuyama H, Takahashi R.
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Journal Title
Internal Medicine
Volume: 52
Pages: 877-85
NAID
Related Report
Peer Reviewed
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[Journal Article] Temporal Lobe Epilepsy with Amygdala Enlargement: A Morphologic and Functional Study.2012
Author(s)
Takaya S, Ikeda A, Mitsueda-Ono T, Matsumoto R, Inouchi M, Namiki C, Oishi N, Mikuni N, Ishizu K, Takahashi R, Fukuyama H
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Journal Title
Journal of Neuroimaging
Volume: 24
Issue: 1
Pages: 54-62
DOI
Related Report
Peer Reviewed
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[Journal Article] Anterior temporal lobe white matter abnormal signal (ATLAS) as an indicator of seizure focus laterality in temporal lobe epilepsy: comparison of double inversion-recovery, FLAIR and T2W MR imaging2012
Author(s)
Morimoto E, Kanagaki M, Okada T, Yamamoto A, Mori N, Matsumoto R, Ikeda A, Mikuni N, Kunieda T, Paul D, Miyamoto S, Takahashi R, Togashi K
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Journal Title
Eur Radiol
Volume: 23
Issue: 1
Pages: 3-11
DOI
Related Report
Peer Reviewed
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[Journal Article] Asymmetric bilateral effect of the supplementary motor area proper in the human motor system.2012
Author(s)
Kikuchi, T., Matsumoto, R., Mikuni, N., Yokoyama, Y., Matsumoto, A., Ikeda, A., Fukuyama, H., Miyamoto, S., & Hashimoto, N.
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Journal Title
Clinical Neurophysiology
Volume: 123
Issue: 2
Pages: 324-334
DOI
Related Report
Peer Reviewed
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[Journal Article] Temporal spread image to delineate MEG spike foci in epilepsy patients2012
Author(s)
Matsuhashi M, Mima T, Fukuyama H, Matsumoto R, Kobayashi K, Ikeda A, Yamao Y, Shibata S, Yokoyama Y, Kunieda T, Mikuni N
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Journal Title
ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings
Volume: art. no. 6275668
Pages: 221-24
Related Report
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[Journal Article] Parieto-frontal network in humans studied by cortico-cortical evoked potential2011
Author(s)
Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S, Fukuyama H, Takahashi R, Najm I, Shibasaki H, Luders HO
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Journal Title
Hum Brain Mapp.
Volume: 33
Issue: 12
Pages: 19-19
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Left anterior temporal cortex actively engages in speech perception : A direct cortical stimulation study2011
Author(s)
Matsumoto R, Imamura H, Inouchi M, Nakagawa T, Yokoyama Y, Matsuhashi M, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
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Journal Title
Neuropsychologia
Volume: 49
Issue: 5
Pages: 1350-1354
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy2011
Author(s)
Hitomi T, Ikeda A, Kondo T, Imamura H, Inouchi M, Matsumoto R, Terada K, Kanda M, Matsuhashi M, Nagamine T, Shibasaki H, Takahashi R
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Journal Title
Mov Disord
Volume: 26
Issue: 8
Pages: 1509-1514
DOI
Related Report
Peer Reviewed
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[Journal Article] Disseminated Nocardia farcinica infection in a patient with myasthenia gravis successfully treated by linezolid: a case report and literature review.2011
Author(s)
Tanioka K, Nagao M, Yamamoto M, Matsumura Y, Tabu H, Matsushima A, Uemura K, Matsumoto R, Ito Y, Takakura S, Takahashi R, Ichiyama S.
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Journal Title
J Infect Chemother
Volume: in press
Issue: 3
Pages: 390-394
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Intraoperative language network monitoring by means of cortico-cortical evoked potentials2014
Author(s)
Yukihiro Yamao, Riki Matsumoto, Takeharu Kunieda, Yoshiki Arakawa, Sumiya Shibata, Rika Inano, Takayuki Kikuchi, Nobukatsu Sawamoto, Nobuhiro Mikuni, Akio Ikeda, Hidenao Fukuyama, Susumu Miyamoto
Organizer
International Congre ss of Clinical Neurophysiology (ICCN2014)
Place of Presentation
Berlin, Germany
Year and Date
2014-03-21
Related Report
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[Presentation] Intraoperative language network monitoring by means of cortico-cortical evoked potentials.2014
Author(s)
Yukihiro Yamao, Riki Matsumoto, Takeharu Kunieda, Yoshiki Arakawa, Sumiya Shibata, Rika Inano, Takayuki Kikuchi, Nobukatsu Sawamoto, Nobuhiro Mikuni, Akio Ikeda, Hidenao Fukuyama, Susumu Miyamoto
Organizer
International Congress of Clinical Neurophysiology (ICCN2014)
Place of Presentation
Berlin, Germany
Related Report
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[Presentation] Epileptic network associated with hypothalamic hamartoma : an EEG-fMRI study2013
Author(s)
Kiyohide Usami, Riki Matsumoto, Nobukatsu Sawamoto, Hiroatsu Murakami, Morito Inouchi, Tomoyuki Fumuro, Akihiro Shimotake, Takeo Kato, Tatsuya Mima, Hiroshi Masuda, Hidenao Fukuyama, Shigeki Kameyama, Akio Ikeda
Organizer
Annual meeting of American Epilepsy Society 2013
Place of Presentation
Washington D.C., USA
Year and Date
2013-12-08
Related Report
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[Presentation] Basal temporal language area revisited in Japanese-its anatomy, function and connectivity2013
Author(s)
Riki Matsumoto, Takeharu Kunieda, Akihiro Shimotake, Hisaji Imamura, Katsuya Kobayashi, Kiyohide Usami, Takayuki Kikuchi, Hidenao Fukuyama, Ryosuke Takahashi, Nobuhiro Mikuni, Susumu Miyamoto, Akio Ikeda
Organizer
Annual meeting of American Epilepsy Society 2013
Place of Presentation
Washington D.C., USA
Year and Date
2013-12-08
Related Report
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[Presentation] Epileptic network associated with hypothalamic hamartoma: an EEG-fMRI study.2013
Author(s)
Kiyohide Usami, Riki Matsumoto, Nobukatsu Sawamoto, Hiroatsu Murakami, Morito Inouchi, Tomoyuki Fumuro, Akihiro Shimotake, Takeo Kato, Tatsuya Mima, Hiroshi Masuda, Hidenao Fukuyama, Shigeki Kameyama, Akio Ikeda.
Organizer
Annual meeting of American Epilepsy Society
Place of Presentation
Washington D.C.,USA
Related Report
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[Presentation] Basal temporal language area revisited in Japanese-its anatomy, function and connectivity.2013
Author(s)
Riki Matsumoto, Takeharu Kunieda, Akihiro Shimotake, Hisaji Imamura, Katsuya Kobayashi, Kiyohide Usami, Takayuki Kikuchi, Hidenao Fukuyama, Ryosuke Takahashi, Nobuhiro Mikuni, Susumu Miyamoto, Akio Ikeda
Organizer
Annual meeting of American Epilepsy Society
Place of Presentation
Washington D.C.,USA
Related Report
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[Presentation] Intraoperative Supplementary Motor Area (SMA) Monitoring for Medial Frontal Lesions.2013
Author(s)
Sumiya Shibata , Takeharu Kunieda , Riki Matsumoto , Yukihiro Yamao , Rika Inano , Takayuki Kikuchi , Yoshiki Arakawa , Toshiya Sugino , Takeshi Funaki , Takafumi Mitsuhara , Masaomi Koyanagi , Kazumichi Yoshida , Yasushi Takagi , Jun Takahashi , Akio Ikeda, Susumu Miyamoto
Organizer
第72回日本脳神経外科学会総会
Place of Presentation
横浜
Related Report
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[Presentation] HFO correlates of cortico-cortical evoked potentials reveal altered excitability in the human epileptic focus2012
Author(s)
Katsuya Kobayashi, Riki Matsumoto, Masao Matsuhashi, Kiyohide Usami, Akihiro Shimotake, Takeharu Kunieda, Nobuhiro Mikuni, Susumu Miyamoto, Hidenao Fukuyama, Ryosuke Takahashi, Akio Ikeda
Organizer
Annual meeting of American Epilepsy Society 2012
Place of Presentation
San Diego, USA
Year and Date
2012-12-03
Related Report
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[Presentation] Sleep stage changes connectivity in human cortices : A cortico-cortical evoked potential study2012
Author(s)
Kiyohide Usami, Riki Matsumoto, Takefumi Hitomi, Katsuya Kobayashi, Akihiro Shimotake, Takeharu Kunieda, Nobuhiro Mikuni, Susumu Miyamoto, Hidenao Fukuyama, Ryosuke Takahashi, Akio Ikeda
Organizer
Society for Neuroscience 2012
Place of Presentation
New Orleans, USA
Year and Date
2012-10-17
Related Report
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[Presentation] Hypothalamic hamartoma and its epileptic network : an EEG-fMRI study2012
Author(s)
Kiyohide Usami, Riki Matsumoto, Nobukatsu Sawamoto, Hiroatsu Murakami, Morito Inouchi, Tomoyuki Fumuro, Akihiro Shimotake, Minoru Shibata, Takeo Kato, Hiroshi Masuda, Tatsuya Mima, Hidenao Fukuyama, Ryosuke Takahashi, Shigeki Kameyama, Akio Ikeda
Organizer
第46回日本てんかん学会
Place of Presentation
東京
Year and Date
2012-10-11
Related Report
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[Presentation] Sleep Changes the Degree of Connectivity in Human Cortices2012
Author(s)
Kiyohide Usami, Riki Matsumoto, Takefumi Hitomi, Katsuya Kobayashi, Akihiro Shimotake, Takeharu Kunieda, Nobuhiro Mikuni, Susumu Miyamoto, Hidenao Fukuyama, Ryosuke Takahashi, AkioIkeda
Organizer
第35回日本神経科学会
Place of Presentation
名古屋
Year and Date
2012-09-21
Related Report
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[Presentation] Comparison between fMRI and direct cortical stimulation for Clinical retinotopic mapping2011
Author(s)
Akihiro Shimotake, Riki Matsumoto, Masanori Kanazu, Hiroki Yamamoto, Masao Matsuhashi, Nobukatsu Sawamoto, Yukihiro Yamao, Nobuhiro Mikuni, Susumu Miyamoto, Hidenao Fukuyama,Ryosuke Takahashi, Akio Ikeda
Organizer
第34回日本神経科学大会
Place of Presentation
横浜
Year and Date
2011-09-16
Related Report
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[Presentation] Comparison between fMRI and direct cortical stimulation for Clinical retinotopic mapping2011
Author(s)
A ShimotakeA, R Matsumoto, M Kanazu, H Yamamoto, M Matsuhashi, N Sawamoto, Y Yamao, N Mikuni, S Miyamoto, H Fukuyama, R Takahashi, A Ikeda
Organizer
第34回日本神経科学大会
Place of Presentation
横浜, パシフィコ横浜
Related Report
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[Presentation] Sleep Changes the Degree of Connectivity in Human Cortices
Author(s)
Kiyohide Usami, Riki Matsumoto, Takefumi Hitomi, Katsuya Kobayashi, Akihiro Shimotake,Takeharu Kunieda, Nobuhiro Mikuni, Susumu Miyamoto, Hidenao Fukuyama, Ryosuke Takahashi, Akio Ikeda
Organizer
第35回日本神経科学会
Place of Presentation
名古屋
Related Report
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[Presentation] Sleep stage changes connectivity in human cortices: A cortico-cortical evoked potential study
Author(s)
Kiyohide Usami, Riki Matsumoto, Takefumi Hitomi, Katsuya Kobayashi, Akihiro Shimotake,Takeharu Kunieda, Nobuhiro Mikuni, Susumu Miyamoto, Hidenao Fukuyama, Ryosuke Takahashi, Akio Ikeda
Organizer
SfN(米国神経学会)2012
Place of Presentation
New Orleans ,USA
Related Report
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[Presentation] Hypothalamic hamartoma and its epileptic network: an EEG-fMRI study
Author(s)
K Usami, R Matsumoto, N Sawamoto, H Murakami, M Inouchi, T Fumuro, A Shimotake, M Shibata, T Kato, H Masuda, T Mima, H Fukuyama, R Takahashi, S Kameyama, A Ikeda
Organizer
第46回日本てんかん学会
Place of Presentation
東京
Related Report
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[Presentation] HFO correlates of cortico-cortical evoked potentials reveal altered excitability in the human epileptic focus
Author(s)
Katsuya Kobayashi, Riki Matsumoto, Masao Matsuhashi, Kiyohide Usami, Akihiro Shimotake, Takeharu Kunieda, Nobuhiro Mikuni, Susumu Miyamoto, Hidenao Fukuyama, Ryosuke Takahashi, Akio Ikeda
Organizer
第66回アメリカてんかん学会
Place of Presentation
サンディエゴ, 米国
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