Investigation for the role of UBE2E2 in insulin secretory machinery and its molecular mechanisms
Project/Area Number |
23591361
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
MINAKO Imamura 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (00596124)
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Co-Investigator(Kenkyū-buntansha) |
MAEDA Shiro 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー (50314159)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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Keywords | 2型糖尿病 / 遺伝要因 / 遺伝子 |
Research Abstract |
We have evaluated the insulin secretion from pancreatic beta-cell line and phenotype of the genetically- modified mice for Ube2e2 to explore the role of UBE2E2 in pancreatic beta-cells. Our results indicate that it is important to consider the influence of environmental factor(s), such as age and obesity, to reveal the mechanism(s) how UBE2E2 contribute to conferring susceptibility to type 2 diabetes. We have also identified several candidates for causal variants by a fine- mapping within the UBE2E2 locus.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Genome-wide association study identifies three novel loci for type 2 diabetes2014
Author(s)
Hara K, Fujita H, Johnson TA, Yamauchi T, Yasuda K, Horikoshi M, Peng C, Hu C, Ma RC, Imamura M, et al
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Journal Title
Hum Mol Genet
Volume: 23
Issue: 1
Pages: 239-246
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Assessing the clinical utility of a genetic risk score constructed using 49 susceptibility alleles for type 2 diabetes in a Japanese population2013
Author(s)
Imamura M, Shigemizu D, Tsunoda T, Iwata M, Maegawa H, Watada H, Hirose H, Tanaka Y, Tobe K, Kaku K, Kashiwagi A, Kawamori R, Maeda S
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Journal Title
J Clin Endocrinol Metab
Volume: 98(10)
Issue: 10
Pages: E1667-E1673
DOI
Related Report
Peer Reviewed
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[Journal Article] Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population2013
Author(s)
Imamura M, Iwata M, Maegawa H, Watada H, Hirose H, Tanaka Y, Tobe K, Kaku K, Kashiwagi A, Kadowaki T, Kawamori R and Maeda S
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Journal Title
J Diabetes Invest
Volume: Volume 4 Issue 2
Issue: 2
Pages: 168-173
DOI
Related Report
Peer Reviewed
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[Journal Article] Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population2013
Author(s)
Sakai K, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S
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Journal Title
PLoS One
Volume: 8
Issue: 9
Pages: e76317-e76317
DOI
Related Report
Peer Reviewed
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[Journal Article] Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population2013
Author(s)
Fukuda H, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S.
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Journal Title
J Hum Genet
Volume: 58
Issue: 7
Pages: 490-493
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population2013
Author(s)
Imamura M, Iwata M, Maegawa H, Watada H, Hirose H, Tanaka Y, Tobe K, Kaku K, Kashiwagi A, Kadowaki T, Kawamori R and Maeda S
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Journal Title
J Diabetes Invest
Volume: 4
Pages: 168-173
Related Report
Peer Reviewed
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[Journal Article] The influence of a single nucleotide polymorphism within CNDP1 on susceptibility to diabetic nephropathy in Japanese women in type 2 diabetes2013
Author(s)
Kurashige M, Imamura M, Araki S, Suzuki D, Babazono T, Suzuki T, Umezono T, Toyoda M, Kawai K, Imanishi M, Hanaoka K, Maegawa H, Uchigata Y, Hosoya T, Maeda S
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Journal Title
PLoS One
Volume: 8
Issue: 1
Pages: e54064-e54064
DOI
Related Report
Peer Reviewed
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[Journal Article] A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.2012
Author(s)
Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K,..., Okada-Iwabu M, Iwabu M, Shojima N,..., Nakamura Y, Kadowaki T
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Journal Title
Human Molecular Genetics
Volume: 21
Issue: 13
Pages: 3042-3049
DOI
Related Report
Peer Reviewed
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[Presentation] Usefulness of genetic risk score constructed from 47 loci for type 2 diabetes in non-obese, older Japanese individuals2013
Author(s)
Minako Imamura, Minoru Iwata, Hiroshi Maegawa, Hirotaka Watada, Hiroshi Hirose, Yasushi Tanaka, Kazuyuki Tobe, Kohei Kaku, Atsunori Kashiwagi, Ryuso Kawamori, Shiro Maeda
Organizer
American Diabetes Association’s 73rd Scientific Sessions
Place of Presentation
McCormick Place、Chicago, Illinois, USA
Related Report
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[Presentation] Usefulness of genetic risk score constructed from 49 loci for type 2 diabetes in Japanese individuals2013
Author(s)
Minako Imamura, Minoru Iwata, Hiroshi Maegawa, Hirotaka Watada, Hiroshi Hirose, Yasushi Tanaka, Kazuyuki Tobe, Kohei Kaku, Atsunori Kashiwagi, Ryuso Kawamori, Shiro Maeda
Organizer
49th EASD Annual Meeting
Place of Presentation
Fira Gran Via (Balcerona) Spain
Related Report
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[Presentation] Imputationに基づくゲノムワイド関連解析による2型糖尿病疾患感受性遺伝子領域の同定2012
Author(s)
今村美菜子, 前田士郎, 山内敏正, 原一雄, 安田一基, 綿田裕孝, 前川聡, 岩田実, 広瀬寛, 加来浩平, 伊藤千賀子, 田中逸, 戸辺一之, 柏木厚典, 河盛隆造, 春日雅人, 中村祐輔, 門脇孝
Organizer
第55回日本糖尿病学会年次学術集会
Place of Presentation
パシフィコ横浜 (横浜市)
Related Report
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[Presentation] Genetic variations in DUSP9 locus and CMIP locus are associated with type 2 diabetes in a Japanese population2012
Author(s)
M. Imamura, H. Fukuda, M. Iwata, H. Maegawa, H. Watada, H. Hirose, Y. Tanaka, K. Tobe, K. Kaku, A. Kashiwagi, R. Kawamori, S. Maeda
Organizer
48th EASD annual meetings
Place of Presentation
Messe Berlin, Berlin, Germany
Related Report
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[Presentation] Rs10906115 in CDC123/CAMK1D locus and rs1359790 near SPRY2 are associated with susceptibility to type 2 diabetes in a Japanese population2011
Author(s)
Minako Imamura, Minoru Iwata, Hiroshi Maegawa, Hirotaka Watada, Hiroshi Hirose, Yasushi Tanaka, Kazuyuki Tobe, Kohei Kaku, Atsunori Kashiwagi, Ryuzo Kawamori, Yusuke Nakamura, Shiro Maeda,
Organizer
47th EASD annual meetings
Place of Presentation
Lisbon Portugal
Related Report
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