Studies on the mechanisms for the prevention of diabetes in NOD mice by AIRE expression
| Project/Area Number |
23591437
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Mitsuru 徳島大学, 疾患酵素学研究センター, 教授 (60221595)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖尿病 / 自己免疫 / NOD / AIRE / AIRE遺伝子 / 遺伝子改変マウス |
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| Research Abstract |
Because AIRE deficiency results in the development of organ-specific autoimmune disease, we attempted to prevent the development of autoimmune diseases by the overexpression of AIRE gene. For this purpose, we introduced human AIRE gene into the oocytes obtained from NOD mice, a strain that spontaneously develops type I diabetes. One line, which showed highest expression of human AIRE, out of four, showed resistance to the development of diabetes. It might be possible to unravel the roles of AIRE in the establishment of self tolerance by studying the mechanisms how overexpressed AIRE could prevent the autoimmunity in this experimental system.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program2014
Author(s)
Nishikawa, Y., Nishijima, H., Matsumoto, M., Morimoto, J., Hirota, F., Takahashi, S., Luche, H., Fehling, H.J., Mouri, Y., Matsumoto, M.
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Journal Title
J. Immunol
Volume: 192
Issue: 6
Pages: 2585-2592
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Which model better fits the role of Aire in the establishment of self-tolerance: the transcription model or the maturation model?2013
Author(s)
Matsumoto, M., Nishikawa, Y., Nishijima, H., Morimoto, J., Matsumoto, M., Mouri, Y.
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Journal Title
Front. Immunol.
Volume: 4
Pages: 1-4
DOI
Related Report
Peer Reviewed
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[Presentation] Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance2013
Author(s)
Nishijima, H, Morimoto, J, Mouri, Y, Nishikawa, Y, Ikuta, K, Matsumoto, M
Organizer
第42回日本免疫学会総会
Place of Presentation
幕張メッセ(千葉県千葉市)
Year and Date
2013-12-11
Related Report
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[Presentation] Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program2013
Author(s)
Matsumoto, M., Nishikawa, Y., Nishijima, H., Matsumoto, M., Hirota, F., Takahashi, S., Luche, H., Fehling, H.S., Mouri, Y
Organizer
The 6^<th> International Workshop of Kyoto T Cell Conference
Place of Presentation
Shiran-Kaikan (Kyoto)
Year and Date
2013-06-03
Related Report
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[Presentation] Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program2013
Author(s)
Matsumoto, M., Nishikawa, Y., Nishijima, H., Matsumoto, M., Morimoto, J., Hirota, F., Takahashi, S., Luche, H., Fehling, H.J., Mouri, Y.
Organizer
The 6th International Workshop of Kyoto T Cell Conference
Place of Presentation
芝蘭会館（京都府）
Related Report
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[Presentation] Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance
Author(s)
Nishijima, H., Morimoto, J., Mouri, Y., Nishikawa, Y., Ikuta, K., Matsumoto, M.
Organizer
第42回日本免疫学会総会
Place of Presentation
幕張メッセ（千葉県）
Related Report
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