Arthritis-inhibiting effects of sunitinib and sorafenib, inhibitors of vascular endothelial growth factor receptor tyrosine kinase.
| Project/Area Number |
23591448
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Research Collaborator |
FURUYA Kazuhiro 東京慈恵会医科大学, リウマチ膠原病内科, 助教
KAKU Ying 東京慈恵会医科大学, リウマチ膠原病内科, 研究技術職
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 関節炎 / 関節リウマチ / スニチニブ / 血管新生 / 血管内皮増殖因子 / チロシンキナーゼ阻害剤 / コラーゲン誘導性関節炎 / 滑膜炎 / 血小板由来成長因子 / チロシンキナーゼ阻害薬 / 骨密度 / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
We confirmed the inhibitory effects of sunitinib, a inhibitor of vascular endothelial growth factor receptor tyrosine kinase, on murine arthritis model.
Sunitinib at a concentration of 0, 30 or 60mg/kg/day was intraperitoneally administrated to mice with collagen-induced arthritis. We compared the changes in arthritis score over time, pathological score, microvascular density in synovial membrane between the vehicle and treatment groups.
In the sunitinib-treated groups, the arthritis score decreased in a dose-dependent manner in comparison with that in the vehicle group. Futhermore, improvement in the pathological score, and a decrease in the synovial microvascular density were also observed in the sunitinib-treated groups.
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Report
(5 results)
Research Products
(7 results)
