Analysis of Th2/17 adjuvant activities and its application
| Project/Area Number |
23591466
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMOJO Naoki 千葉大学, 医学部, 教授 (40221303)
NAKAGOME Kazuyuki 埼玉医科大学, 医学部, 講師 (60401113)
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| Research Collaborator |
SASAKI Takumi 化学及血清療法研究所
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アレルギー学 / アトピー性皮膚炎 / CoA / ドパミン受容体 / 潰瘍性大腸炎 / 乾癬 / 好中球気道炎症 / wogonin |
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| Outline of Final Research Achievements |
We previously showed that dopamine-mediated cAMP elevation in human naïve CD4 T cells was completely inhibited by treatment with a D1-like receptor antagonist SCH-23390, which inhibited dopamine-mediated IL-6/17 secretion from T cells. We studied the effect of SCH-23390 with the SCID mice in which active RA synovial tissue and cartilage have been engrafted. Retraction of synovial tissue was observed in the SCH-23390-treated group. It was also effective in OVA-induced neutrophilic airway inflammation. Mothers, whose children developed atopic dermatitis (AD), often demonstrate a higher Th2 adjuvant activity in their milk. We showed that this is attributable to Coenzyme A (CoA), which exhibited Th2 adjuvant activity both in vitro and in vivo. Furthermore, the oral administration of CoA induced AD-like skin in mice. These data indicate that some of the patients with AD were exposed to Th2 adjuvant via mothers’ milk with high CoA content.
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Report
(5 results)
Research Products
(35 results)
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[Journal Article] Chimeric SV40 virus-like particles induce specific cytotoxicity and protective immunity against influenza A virus without the need of adjuvants.2014
Author(s)
Kawano, M., Morikawa, K., Suda, T., Ohno, N., Matsushita, S., Akatsuka, T.,Handa, H., and Matsui, M.
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Journal Title
Virology
Volume: 448
Pages: 159-167
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Wogonin attenuates ovalbumin antigen-induced neutrophilic airway inflammation by inhibiting Th17 differentiation.2014
Author(s)
Takagi, R., Kawano, M., Nakagome, K., Hashimoto, K., Higashi, T., Ohbuchi, K., Kaneko, A. and Matsushita, S.
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Journal Title
Int. J. Inflamm.
Volume: Article ID 571508
Pages: 1-8
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dopamine Induces IL-6_Dependent IL-17 Production via D1-Like Receptor on CD4 Naive T Cells and D1-Like Receptor Antagonist SCH-23390 Inhibits Cartilage Destruction in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model.2011
Author(s)
Nakano, K., Yamaoka, K., Hanami, K., Saito, K., Sasaguri, Y., Yanagihara, N., Tanaka, S., Katsuki, I., Matsushita, S and Tanaka Y.
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Journal Title
J. Immunol.
Volume: 186
Pages: 3745-3752
Related Report
Peer Reviewed
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[Journal Article] Therapeutic effect of D1-like dopamine receptor antagonist on collagen-induced arthritis of mice.2011
Author(s)
Nakashioya, H., Nakano, K., Watanabe, N., Miyasaka, N., Matsushita, S., Kohsaka, H.
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Journal Title
Modern Rheumatol.
Volume: 21
Pages: 260-266
NAID
Related Report
Peer Reviewed
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[Journal Article] Coenzyme A contained in mothers’ milk is associated with the potential to induce atopic dermatitis.2011
Author(s)
Higashi, T., Shimojo, N., Suzuki, S., Nakaya, M., Takagi, R., Hashimoto, K., Nakagome, K., Nakamura, K., Kohno, Y. and Matsushita, S.
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Journal Title
Int. Immunol.
Volume: 23
Pages: 741-749
Related Report
Peer Reviewed
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[Presentation] 免疫療法の基礎2014
Author(s)
松下 祥
Organizer
第１回総合アレルギー講習会
Place of Presentation
神奈川県「パシフィコ横浜」
Year and Date
2014-12-20
Related Report
Invited
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