| Project/Area Number |
23591480
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagoya City University |
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Principal Investigator |
NAKMAURA Atsushi 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (40285200)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Hideaki 名古屋市立大学, 大学院医学研究科, 講師 (30418868)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Clostridium difficile / 抗菌薬関連性腸炎 / 毒素遺伝子 / Binary toxin / NAAT / 抗菌薬関連腸炎 / タイピング / 地域ネットワーク |
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| Outline of Final Research Achievements |
In Japan, establishement of accurate methods of diagnosis, tratment ,or nosocomial infection prevention measures against Clostridium difficile infection (CDI) is required, but the clinical informations have not yet been fully revealed. For the purpose of presenting the important reference data for constracting CDI practical guidelines, we carried out analysis of CDI cases and those crinical isolates.
As a result, it had not been observed the correlation between possessing toxin gene type and clinical severity. Drug resistance to the current therapeutic agents was not observed, and the difference by administered drug, the dosage, or administration period had not seen. Nucleic acid amplification test of toxin gene showed high diagnostic accuracy compared with the current rapid diagnostic method, and in the future, it could be expected the usefulness of CDI diagnosis.
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