Analysis of pathogenesis of acute encephalopathy in children

• Project/Area Number: 23591518
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Juntendo University
• Principal Investigator: OKUMURA Akihisa 順天堂大学, 医学部, 准教授 (60303624)
• Co-Investigator(Kenkyū-buntansha): HAYAKAWA Masahiro 名古屋大学, 医学部附属病院, 教授 (40343206) ; HAYASHI Masaharu 財団法人東京都医学総合研究所, 脳発達神経再生研究分野, プロジェクトリーダー (00280777)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 自己免疫 / 抗神経抗体 / 急性脳症 / 免疫組織化学染色法 / 辺縁系脳炎 / 基底核脳炎 / 急性脳炎・脳症 / 自己抗体 / イムノブロット / 免疫組織染色 / 刺激試験 / ウエスタンブロット

Research Abstract

Autoimmune process is presumed to contribute in acute encephalopathy in children. However, the methods for detecting autoantibodies have not been established. We measured serum autoantibodies in children with acute encephalopathy using several different methods. The subject of this study is 16 children with acute encephalopathy suspected to have autoimmune encephalopathy. We measured autoantibodies using the following methods: 1) immunoblot using prepared membrane with human brain derived proteins (IB), 2) immunohistochemical studies using rat brain tissue (rat IHC), 3) immunohistochemical studies using control human brain tissue (human IHC). Autoantibodies were detected in 5 children by IB, 11 by rat IHC, and 10 by human IHC. The results of examinations were not always consistent among methods of measurement. Our study revealed that IHC will be more sensitive than IB. However, the detection of autoantibody should be made in combination of several detection methods.

Research Products

• [Journal Article] Unexpected cardiopulmonary arrest associated with influenza : our experience during the 2009 pandemic in Japan (2013)
  • Author(s): Okumura A, et al.
  • Journal Title: Influenza Other Respi Viruses Volume: 7 Pages: 759-760
  • Peer Reviewed
• [Journal Article] Severe form of encephalopathy associated with 2009 pandemic influenza A (H1N1) in Japan (2013)
  • Author(s): Okumura A, et al.
  • Journal Title: J Clin Virol Volume: 56 Pages: 25-30
  • Peer Reviewed
• [Journal Article] Whole-exome sequencing of a unique brain malformation with periventricular heterotopia, cingulate polymicrogyria and midbrain tectal hyperplasia (2013)
  • Author(s): Okumura A, Hayashi M, et al.
  • Journal Title: Neuropathology Volume: 33 Pages: 553-560
  • Peer Reviewed
• [Journal Article] Acute limbic encephalitis with focal hyperperfusion on single photon emission computed tomography (2013)
  • Author(s): Igarashi A, Okumura A, Hayashi M, et al. (5名省略)
  • Journal Title: Brain Dev Volume: 35 Pages: 181-184
  • Peer Reviewed
• [Journal Article] Neonatal seizure identification on reduced channel EEG (2013)
  • Author(s): Kidokoro H, Kubota T, Hayakawa M, Kato Y, Okumura A.
  • Journal Title: Arch Dis Child Fetal Neonatal Ed Volume: 98
  • Peer Reviewed
• [Journal Article] Safety evaluation of laninamivir octanoate hydrate through analysis of adverse events reported during early post-marketing phase vigilance (2013)
  • Author(s): Nakano T, Okumura A, et al. (6名省略)
  • Journal Title: Scand J Infect Dis Volume: 45 Pages: 469-477
  • Peer Reviewed
• [Journal Article] Severe form of encephalopathy associated with 2009 pandemic influenza A (H1N1) in Japan. (2013)
  • Author(s): Okumura A, Nakagawa S, Kawashima H, Morichi S, Muguruma T, Saito O, Fujimoto JI, Toida C, Kuga S, Imamura T, Shimizu T, Kondo N, Morishima T.
  • Journal Title: J Clin Virol Volume: 56 Issue: 1 Pages: 25-30
  • DOI: 10.1016/j.jcv.2012.10.007
  • Peer Reviewed
• [Journal Article] Unexpected cardiopulmonary arrest associated with influenza: our experience during the 2009 pandemic in Japan. (2013)
  • Author(s): Okumura A, Nakagawa S, Kawashima H, Muguruma T, Saito O, Fujimoto J, Toida C, Kuga S, Imamura T, Shimizu T, Kondo N, Morishima T
  • Journal Title: Influenza Other Respi Viruses Volume: 7 Issue: 5 Pages: 759-760
  • DOI: 10.1111/irv.12032
  • Peer Reviewed
• [Journal Article] Acute limbic encephalitis with focal hyperperfusion on single photon emission computed tomography. (2013)
  • Author(s): Igarashi A et al.
  • Journal Title: Brain Dev. Volume: 35 Issue: 2 Pages: 181-184
  • DOI: 10.1016/j.braindev.2012.03.014
  • Peer Reviewed
• [Journal Article] Human herpesvirus 6-associated encephalopathy in a child with dravet syndrome (2013)
  • Author(s): Hiraiwa-Sofue A, Ito Y, Ohta R, Kimura H, Okumura A
  • Journal Title: Neuropediatrics Volume: 44 Issue: 03 Pages: 155-158
  • DOI: 10.1055/s-0032-1327772
  • Peer Reviewed
• [Journal Article] Safety evaluation of laninamivir octanoate hydrate through analysis of adverse events reported during early post-marketing phase vigilance. (2013)
  • Author(s): Nakano T, Okumura A, Tanabe T, Niwa S, Fukushima M, Yonemochi R, Eda H, Tsutsumi H.
  • Journal Title: Scand J Infect Dis Volume: 45 Issue: 6 Pages: 469-477
  • DOI: 10.3109/00365548.2012.763104
  • Peer Reviewed
• [Journal Article] Acute encephalopathy in children with Dravet syndrome (2012)
  • Author(s): Okumura A, et al. (14名省略)
  • Journal Title: Epilepsia Volume: 53 Pages: 79-86
  • Peer Reviewed
• [Journal Article] Acute encephalopathy with 2009 pandemic flu : Comparison with seasonal flu (2012)
  • Author(s): Okumura A, et al. (8名省略)
  • Journal Title: Brain Dev Volume: 34 Pages: 13-19
  • NAID: 10031049369
  • Peer Reviewed
• [Journal Article] Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) (2012)
  • Author(s): Miyata R, Hayashi M, Okumura A, et al. (8名省略)
  • Journal Title: Brain Dev Volume: 34 Pages: 124-127
  • NAID: 10031049788
  • Peer Reviewed
• [Journal Article] National survey of pandemic influenza A (H1N1) 2009-associated encephalopathy in Japanese children (2012)
  • Author(s): Kawashima H, Okumura A, et al. (3名省略、)
  • Journal Title: J Med Virol Volume: 84 Pages: 1151-1156
  • Peer Reviewed
• [Journal Article] Prognostic factors in acute encephalopathy with reduced subcortical diffusion (2012)
  • Author(s): Hayashi N, Okumura A, et al. (7名省略)
  • Journal Title: Brain Dev Volume: 34 Pages: 632-639
  • Peer Reviewed
• [Journal Article] Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children (2012)
  • Author(s): Kawashima H, Okumura A, et al. (3名省略)
  • Journal Title: Scand J Infect Dis Volume: 44 Pages: 941-947
  • Peer Reviewed
• [Journal Article] Acute encephalopathy with 2009 pandemic flu: Comparison with seasonal flu. (2012)
  • Author(s): Okumura A, Tsuji T, Kubota T, Ando N, Kobayashi S, Kato T, Natsume J, Hayakawa F, Shimizu T.
  • Journal Title: Brain Dev Volume: 34 Issue: 1 Pages: 13-19
  • DOI: 10.1016/j.braindev.2011.01.004
  • NAID: 10031049369
  • Peer Reviewed
• [Journal Article] Acute encephalopathy in children with Dravet syndrome. (2012)
  • Author(s): Okumura A, Uematsu M, Imataka G, Tanaka M, Okanishi T, Kubota T, Sudo A, Tohyama J, Tsuji M, Ohmori I, Naiki M, Hiraiwa-Sofue A, Sato H, Saitoh S, Shimizu T.
  • Journal Title: Epilepsia Volume: 53 Issue: 1 Pages: 79-86
  • DOI: 10.1111/j.1528-1167.2011.03311.x
  • Peer Reviewed
• [Journal Article] A severe form of epidermal nevus syndrome associated with brainstem and cerebellar malformations and neonatal medulloblastoma. (2012)
  • Author(s): Okumura A, Lee T, Ikeno M, Shimojima K, Kajino K, Inoue Y, Yoshikawa N, Suganuma H, Suzuki M, Hisata K, Shoji H, Takanashi J, James Barkovich A, Shimizu T, Yamamoto T, Hayashi M.
  • Journal Title: Brain Dev Volume: 34 Issue: 10 Pages: 881-885
  • DOI: 10.1016/j.braindev.2012.03.003
  • Peer Reviewed
• [Journal Article] Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). (2012)
  • Author(s): Miyata R et al.
  • Journal Title: Brain Dev. Volume: 34 Issue: 2 Pages: 124-127
  • DOI: 10.1016/j.braindev.2011.04.004
  • Peer Reviewed
• [Journal Article] A 15-month-old boy with reduced consciousness and convulsion. (2012)
  • Author(s): Oikawa N, Okumura A, Oyama S, Baba H, Shimizu T, Kato A.
  • Journal Title: J Clin Virol Volume: 53 Issue: 4 Pages: 276-279
  • DOI: 10.1016/j.jcv.2012.01.021
  • Peer Reviewed
• [Journal Article] Pertussis-associated encephalitis/encephalopathy with marked demyelination in an unimmunized child. (2012)
  • Author(s): Hiraiwa-Sofue A, Ito Y, Mori H, Ichiyama T, Okumura A
  • Journal Title: J Neurol Sci Volume: 320 Issue: 1-2 Pages: 145-148
  • DOI: 10.1016/j.jns.2012.06.010
  • Peer Reviewed
• [Journal Article] EEG for predicting early neurodevelopment in preterm infants: an observational cohort study. (2012)
  • Author(s): Hayashi-Kurahashi N, Kidokoro H, Kubota T, Maruyama K, Kato Y, Kato T, Natsume J, Hayakawa F, Watanabe K, Okumura A
  • Journal Title: Pediatrics Volume: 130 Issue: 4 Pages: e891-e897
  • DOI: 10.1542/peds.2012-1115
  • Peer Reviewed
• [Journal Article] Prognostic factors in acute encephalopathy with reduced subcortical diffusion. (2012)
  • Author(s): Hayashi N, Okumura A, Kubota T, Tsuji T, Kidokoro H, Fukasawa T, Hayakawa F, Ando N, Natsume J.
  • Journal Title: Brain Dev Volume: 34 Issue: 8 Pages: 632-639
  • DOI: 10.1016/j.braindev.2011.11.007
  • Peer Reviewed
• [Journal Article] National survey of pandemic influenza A (H1N1) 2009-associated encephalopathy in Japanese children. (2012)
  • Author(s): Kawashima H, Morichi S, Okumura A, Nakagawa S, Morishima T; collaborating study group on influenza-associated encephalopathy in Japan.
  • Journal Title: J Med Virol Volume: 84 Issue: 8 Pages: 1151-1156
  • DOI: 10.1002/jmv.23317
  • Peer Reviewed
• [Journal Article] Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children. (2012)
  • Author(s): Kawashima H, Morichi S, Okumura A, Nakagawa S, Morishima T; The Collaborating Study Group On Influenza-Associated Encephalopathy In Japan.
  • Journal Title: Scand J Infect Dis Volume: 44 Issue: 12 Pages: 941-947
  • DOI: 10.3109/00365548.2012.700769
  • Peer Reviewed
• [Journal Article] Deaths associated with pandemic (H1N1) 2009 among children, Japan, 2009–2010 (2011)
  • Author(s): Okumura A, et al. (11名省略)
  • Journal Title: Emerg Infect Dis Volume: 17 Pages: 1993-2000
  • Peer Reviewed
• [Journal Article] Acute encephalopathy in a child with secondary carnitine deficiency due to pivalate-conjugated antibiotics (2011)
  • Author(s): Okumura A, et al. (4名省略)
  • Journal Title: Pediatr Infect Dis J Volume: 30 Pages: 92-92
  • Peer Reviewed
• [Journal Article] Amplitude-integrated electroencephalography in patients with acute encephalopathy with refractory, repetitive partial seizures (2011)
  • Author(s): Okumura A, et al. (6名省略)
  • Journal Title: Brain Dev Volume: 33
  • NAID: 10029560284
  • Peer Reviewed
• [Journal Article] Amplitude-integrated electroencephalography in preterm infants with cystic periventricular leukomalacia (2011)
  • Author(s): Kato T, Okumura A, Hayakawa M, et al. (3名省略)
  • Journal Title: Early Hum Dev Volume: 87 Pages: 217-221
  • Peer Reviewed
• [Journal Article] Chronological diffusion-weighted imaging changes and mutism in the course of rotavirus-associated acute cerebellitis/cerebellopathy concurrent with encephalitis/encephalopathy (2011)
  • Author(s): Kubota T, Okumura A, et al. (6名省略)
  • Journal Title: Brain Dev Volume: 33 Pages: 21-27
  • NAID: 10029560057
  • Peer Reviewed
• [Journal Article] Transient and mild reduction of consciousness during febrile illness in children (2011)
  • Author(s): Kato T, Okumura A, et al. (4名省略)
  • Journal Title: Neuropediatrics Volume: 42 Pages: 183-187
  • Peer Reviewed
• [Journal Article] Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes (2011)
  • Author(s): Hoshino A, Saitoh M, Oka A, Okumura A, Kubota M, Saito Y, Takanashi J, Hirose S, Yamagata T, Yamanouchi H, Mizuguchi M
  • Journal Title: Brain Dev Volume: 34 Issue: 5 Pages: 337-343
  • DOI: 10.1016/j.braindev.2011.07.012
  • Peer Reviewed
• [Journal Article] Amplitude-integrated electroencephalography in patients with acute encephalopathy with refractory, repetitive partial seizures. (2011)
  • Author(s): Okumura A, Komatsu M, Abe S, Kitamura T, Matsui K, Ikeno M, Shimizu T.
  • Journal Title: Brain Dev Volume: 33 Issue: 1 Pages: 77-82
  • DOI: 10.1016/j.braindev.2009.12.009
  • NAID: 10029560284
  • Peer Reviewed
• [Journal Article] Acute encephalopathy in a child with secondary carnitine deficiency due to pivalate-conjugated antibiotics. (2011)
  • Author(s): Okumura A, Morita M, Ikeno M, Abe S, et al.
  • Journal Title: Pediatr Infect Dis J Volume: 30 Issue: 1 Pages: 92-92
  • DOI: 10.1097/inf.0b013e3181fe3953
  • Peer Reviewed
• [Journal Article] Transiently restricted diffusion in the corpus callosum in bacterial meningitis. (2011)
  • Author(s): Okumura A, Kitamura Y, Abe S, Ikeno M, Shimizu T.
  • Journal Title: J Pediatr Infect Dis Volume: 6 Pages: 51-53
  • Peer Reviewed
• [Journal Article] Refractory neonatal epilepsy with a de novo duplication of chromosome 2q24.2q24.3 (2011)
  • Author(s): Okumura, A., et al
  • Journal Title: Epilepsia Volume: 52 Issue: 7 Pages: e66-e69
  • DOI: 10.1111/j.1528-1167.2011.03139.x
  • Peer Reviewed
• [Journal Article] Deaths associated with pandemic (H1N1) 2009 among children, Japan, 2009-2010. (2011)
  • Author(s): Okumura A, Nakagawa S, et al.
  • Journal Title: Emerg Infect Dis 2011; 17: Volume: 17 Issue: 11 Pages: 1993-2000
  • DOI: 10.3201/eid1711.110649
  • Peer Reviewed
• [Journal Article] Chronological diffusion-weighted imaging changes and mutism in the course of rotavirus-associated acute cerebellitis/cerebellopathy concurrent with encephalitis/encephalopathy. (2011)
  • Author(s): Kubota T, Suzuki T, et al..
  • Journal Title: Brain Dev Volume: 33 Issue: 1 Pages: 21-27
  • DOI: 10.1016/j.braindev.2010.04.007
  • Peer Reviewed
• [Journal Article] Early infantile manifestations of incontinentia pigmenti mimicking acute encephalopathy (2011)
  • Author(s): Abe S, Okumura A, et al.
  • Journal Title: Brain Dev Volume: 33 Issue: 1 Pages: 28-34
  • DOI: 10.1016/j.braindev.2010.04.002
  • NAID: 10029560087
  • Peer Reviewed
• [Journal Article] Clinical trial of minimal treatment for clustering seizures in cases of convulsions with mild gastroenteritis (2011)
  • Author(s): Tanabe T, et al.
  • Journal Title: Brain Dev Volume: 33 Issue: 2 Pages: 120-124
  • DOI: 10.1016/j.braindev.2010.02.007
  • Peer Reviewed
• [Journal Article] Epilepsies and epileptic syndromes starting in the neonatal period. (2011)
  • Author(s): Yamamoto H, Okumura A, Fukuda M.
  • Journal Title: Brain Dev Volume: 33 Issue: 3 Pages: 213-220
  • DOI: 10.1016/j.braindev.2010.10.009
  • NAID: 10029560830
  • Peer Reviewed
• [Journal Article] Amplitude-integrated electroencephalography in preterm infants with cystic periventricular leukomalacia. (2011)
  • Author(s): Kato T, et al.
  • Journal Title: Early Hum Dev Volume: 87 Issue: 3 Pages: 217-221
  • DOI: 10.1016/j.earlhumdev.2010.12.008
  • Peer Reviewed
• [Journal Article] Late-onset sensorineural hearing loss due to asymptomatic congenital cytomegalovirus infection retrospectively diagnosed by polymerase chain reaction using preserved umbilical cord. (2011)
  • Author(s): Ikeno M, et al.
  • Journal Title: Clin Pediatr Volume: 50 Issue: 7 Pages: 666-668
  • DOI: 10.1177/0009922810380903
  • Peer Reviewed
• [Journal Article] Acute encephalopathy in a patient with Dravet syndrome. (2011)
  • Author(s): Tsuji M, Mazaki E, Ogiwara I, Wada T, Iai M, Okumura A, Yamashita S, Yamakawa K, Osaka H
  • Journal Title: Neuropediatrics Volume: 42 Issue: 02 Pages: 78-81
  • DOI: 10.1055/s-0031-1279725
  • Peer Reviewed
• [Journal Article] Evaluation of brain maturation in pre-term infants using conventional and amplitude-integrated electroencephalograms. (2011)
  • Author(s): Kato T, et al.
  • Journal Title: Clin Neurophysiol Volume: 122 Issue: 10 Pages: 1967-1972
  • DOI: 10.1016/j.clinph.2010.12.063
  • Peer Reviewed
• [Journal Article] SCN1B is not related to benign partial epilepsy in infancy or convulsions with gastroenteritis (2011)
  • Author(s): Yamashita, S., et al
  • Journal Title: Neuropediatrics Volume: 42 Issue: 04 Pages: 135-137
  • DOI: 10.1055/s-0031-1285837
  • Peer Reviewed
• [Journal Article] CDKL5 alterations lead to early epileptic encephalopathy in both genders (2011)
  • Author(s): Jao-Shwann Liang, Keiko Shimojima, Rumiko Takayama, Jun Natsume, MinobuShichiji, Kyoko Hirasawa, Kaoru Imai, Tohru Okanishi, Seiji Mizuno, Akihisa Okumura, Midori Sugawara, Tomoshiro Ito, Hiroko Ikeda, Yukitoshi Takahashi, Hirokazu Oguni, Katsumi Imai, Makiko Osawa, Toshiyuki Yamamoto
  • Journal Title: Epilepsia Volume: 52-10 Issue: 10 Pages: 1835-1842
  • DOI: 10.1111/j.1528-1167.2011.03174.x
  • Peer Reviewed
• [Journal Article] Transient and Mild Reduction of Consciousness during Febrile Illness in Children. (2011)
  • Author(s): Kato T, et al.
  • Journal Title: Neuropediatrics Volume: 42 Issue: 05 Pages: 183-187
  • DOI: 10.1055/s-0031-1295411
  • Peer Reviewed
• [Presentation] Attitude toward Epilepsy after Media Coverage of Car Accidents Related to Persons with Epilepsy in Japan (2013)
  • Author(s): Akihisa Okumura, et al
  • Organizer: 第47回日本てんかん学会学術集会
  • Place of Presentation: 北九州
  • Year and Date: 2013-10-11
• [Presentation] 新生児発作に対するホスフェニトインの使用経験 (2013)
  • Author(s): 奥村彰久、他
  • Organizer: 第49回日本周産期・新生児医学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2013-07-15
• [Presentation] Attitude toward Epilepsy after Media Coverage of Car Accidents Related to Persons with Epilepsy in Japan (2013)
  • Author(s): Akihisa Okumura, et al
  • Organizer: 30th International Epilepsy Congress
  • Place of Presentation: Montreal
  • Year and Date: 2013-06-24
• [Presentation] Whole-exome sequencing identifies FLNB variant in a unique brain malformation (2013)
  • Author(s): Akihisa Okumura, et al
  • Organizer: 第55回小児神経学会総会
  • Place of Presentation: 大分
  • Year and Date: 2013-05-30
• [Presentation] インフルエンザに伴う予期せぬ心肺停止:パンデミック2009小児死亡例の実態調査から (2013)
  • Author(s): 奥村彰久、他
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島
  • Year and Date: 2013-04-20
• [Presentation] インフルエンザに伴う予期せぬ心肺停止：パンデミック2009 小児死亡例の実態調査から． (2013)
  • Author(s): 奥村彰久、中川聡、河島尚志、清水俊明、近藤直実、森島恒雄、新型インフルエンザ死亡例調査グループ．
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島
• [Presentation] Whole-exome sequencing identifies FLNB variant in a unique brain malformation. (2013)
  • Author(s): Akihisa Okumura, Masaharu Hayashi, Keiko Shimojima, Mitsuru Ikeno, Shinpei Abe, Jun-ichi Takanashi, Nobuhiko Okamoto, Toshiaki Shimizu, Toshiyuki Yamamoto.
  • Organizer: 第55回小児神経学会総会
  • Place of Presentation: 大分
• [Presentation] 急性脳症をいかに理解するか：今後の研究アプローチ (2013)
  • Author(s): 奥村彰久
  • Organizer: 第55回小児神経学会総会
  • Place of Presentation: 大分
  • Invited
• [Presentation] PRRT2 Mutation in Japanese Children with Benign Infantile Epilepsy (2012)
  • Author(s): Okumura, et al
  • Organizer: The 16th Anunal Meeting of American Epilepsy Society
  • Place of Presentation: San Diego
  • Year and Date: 2012-12-02
• [Presentation] 新生児および乳幼児の発作-aEEGによる評価- (2012)
  • Author(s): 奥村彰久
  • Organizer: 第46回日本てんかん学会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-10
• [Presentation] Neonatal EEG in determining risk to the preterm brain (2012)
  • Author(s): Akihisa Okumura
  • Organizer: Joint congress of the 12th International Child Neurology Congress and the 11th Asian and Oceanian Congress of Child Neurology
  • Place of Presentation: Brisbane
  • Year and Date: 2012-06-01
• [Presentation] Autoimmune encephalitis proven by immunohistochemical study (2012)
  • Author(s): Akihisa Okumura, et al
  • Organizer: 第54回日本小児神経学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-05-17
• [Presentation] アトキンス食に伴う成長障害 (2012)
  • Author(s): 奥村彰久、他
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-19
• [Presentation] Autoimmune Encephalitis Proven by Immunohistochemical Study (2012)
  • Author(s): Akihisa Okumura, Tetsuo Kubota, Motomasa Suzuki, Tatsuya Fukazawa, Shinpei Abe, Mitsuru Ikeno, Mariko Hosozawa, Toshiaki Shimizu, Masaharu Hayashi.
  • Organizer: 第54回日本小児神経学会総会
  • Place of Presentation: 札幌
• [Presentation] Neonatal EEG in determining risk to the preterm brain (2012)
  • Author(s): Akihisa Okumura
  • Organizer: Joint congress of the 12th International Child Neurology Congress and the 11th Asian and Oceanian Congress of Child Neurology
  • Place of Presentation: Brisbane, Austlaria
  • Invited
• [Presentation] TUBA1A変異による滑脳症・脳室拡大・小脳低形成の1剖検例 (2012)
  • Author(s): 奥村彰久、池野充、久田研、東海林宏道、清水俊明
  • Organizer: 第48回日本周産期・新生児医学会学術集会
  • Place of Presentation: さいたま
• [Presentation] PRRT2 Mutation in Japanese Children with Benign Infantile Epilepsy (2012)
  • Author(s): Akihisa Okumura, Keiko Shimojima, Tetsuo Kubota, et al.
  • Organizer: 第46回日本てんかん学会
  • Place of Presentation: 東京
• [Presentation] 小児急性脳症の脳波 (2012)
  • Author(s): 奥村彰久
  • Organizer: 第17回日本神経感染症学会総会
  • Place of Presentation: 京都
  • Invited
• [Presentation] 新生児および小児におけるamplitude-integrated EEGの臨床応用 (2012)
  • Author(s): 奥村彰久
  • Organizer: 第42回日本臨床神経生理学会・学術大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] PRRT2 Mutation in Japanese Children with Benign Infantile Epilepsy. (2012)
  • Author(s): Akihisa Okumura, Keiko Shimojima , Tetsuo Kubota , et al.
  • Organizer: he 16th Anunal Meeting of American Epilepsy Society
  • Place of Presentation: San Diego, CA, USA
• [Presentation] 新生児発作・新生児発作様イベントの症状型分類の実証的検討 (2011)
  • Author(s): 奥村彰久、他
  • Organizer: 第56回日本未熟児新生児学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-14
• [Presentation] 2番染色体長腕の微小重複を伴う難治性新生児てんかんの1例 (2011)
  • Author(s): 奥村彰久、他
  • Organizer: 第45回日本てんかん学会総会
  • Place of Presentation: 新潟
  • Year and Date: 2011-10-06
• [Presentation] Neonatal seizures and epilepsy (2011)
  • Author(s): Akihisa Okumura
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Rome
  • Year and Date: 2011-09-01
• [Presentation] 2009 Pandemic Flu A (H1N1)小児死亡例の実態調査 (2011)
  • Author(s): 奥村彰久、他
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-14
• [Presentation] 2009 Pandemic Flu A (H1N1)による急性脳症死亡例の臨床像 (2011)
  • Author(s): 奥村彰久、他
  • Organizer: 第53回日本小児神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-05-27
• [Presentation] Neonatal seizures (2011)
  • Author(s): Akihisa Okumura
  • Organizer: The 15th Annual Meetings of Taiwan Child Neurology Society(招待講演)
  • Place of Presentation: Taipei
• [Presentation] Acute encephalopathy in children (2011)
  • Author(s): Akihisa Okumura
  • Organizer: Invited lecture at National Taiwan University Hospita(招待講演)
  • Place of Presentation: Taipei
• [Presentation] Neonatal seizures and epilepsy (2011)
  • Author(s): Akihisa Okumura
  • Organizer: 29th International Epilepsy Congress(招待講演)
  • Place of Presentation: Rome
• [Book] 発作時脳波からみた小児てんかん (2011)
  • Author(s): 奥村彰久、根来民子、夏目淳、渡邊一功
  • Total Pages: 150
  • Publisher: 診断と治療社