The role of angiopoietin-like protein 4 (ANGPTL4) in the glomerular endothelial cell injury and progressive glomerular injury
| Project/Area Number |
23591570
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KAGAMI Shoji 徳島大学, ヘルスバイオサイエンス研究部, 教授 (00224337)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Shuji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 講師 (00380080)
ROKUTAN Kazuhito 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (10230898)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | アンジオテンシンII / 糸球体内皮細胞 / アンジオテンシノーゲン / ANGPTL4 / p63 / アンジオテンシン変換酵素 / 国際情報交換 イギリス / 国際情報交流 イギリス |
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| Research Abstract |
This study is performed to find the molecular targets in treatment for preventing the progression of kidney diseases. We identified the angiopoietin-like protein 4 (ANGPTL4) involved in glomerular endothelial cell (GEC) injury among many induced genes during the course of progressive kidney injury. In the rat models of chronic glomerulonephritis, we found the good correlation among the expression of glomerular renin-angiotensin (ang) system (RAS) components, the expression of GEC- ANGPTL4 and the level of glomerular injury. Inhibition of RAS with inhibitors decrease the levels of those molecules as well as glomerular injury, suggesting that GEC- ANGPTL4 may be regulated under control of glomerular RAS expression. Additionally, we also found that p63 is involved in ang II-induced GEC- ANGPTL4 expression. Therefore, weconclude that ANGPTL4 as well as p63 protein in GEC may be novel molecular targets for regulating the progression of kidney diseases.
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Report
(4 results)
Research Products
(102 results)
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[Journal Article] Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010.2013
Author(s)
Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Kawamura T, Takeda T, Hataya H, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Shimizu A, Kitamura H, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Nagata M, Taguchi T, Makino H
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Journal Title
Clin Exp Nephrol.
Volume: 17(2)
Issue: 2
Pages: 155-73
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] A case of infantile systemic lupus erythematosus with severe lupus nephritis and EBV infection2013
Author(s)
Kishi N, Suga K, Matsuura S, Kinoshita Y, Urushihara M, Kondo S, Kitano E, Hatanaka M, Kitamura H, Sato T, Maeda A, Kagami S.
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Journal Title
CEN Case Rep
Volume: 2
Pages: 190-193
Related Report
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[Journal Article] A case of infantile systemic lupus erythematosus with severe lupus nephritis and EBV infection.2013
Author(s)
Kishi N, Suga K, Matsuura S, Kinoshita Y, Urushihara M, Kondo S, Kitano E, Hatanaka M, Kitamura H, Sato T, Maeda A, Kagami S
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Journal Title
CEN Case Rep
Volume: 2
Pages: 190-193
Related Report
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[Journal Article] Angiotensin II type I receptor blockade suppresses glomerular renin-angiotensin system activation, oxidative stress, and progressive glomerular injury in rat anti-glomerular basement membrane glomerulonephritis2012
Author(s)
Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, Shimizu M, Nishiyama A, Kawachi H, Kagami S
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Journal Title
Transl Res
Volume: 158
Issue: 4
Pages: 235-48
DOI
Related Report
Peer Reviewed
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[Journal Article] A case of a 6-year-old girl with ANCA-negative pauci-immune crescentic glomerulonephritis2011
Author(s)
Shimizu M, Sekiguchi T, Kishi N, Goji A, Takahashi T, Kozan H, Sakaguchi Z, Kinoshita Y, Matsuura S, Suga K, Urushihara M, Kondo S, Kagami S, Ohara K
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Journal Title
Clin Exp Nephrol
Volume: 21
Issue: 4
Pages: 2380-2390
DOI
Related Report
Peer Reviewed
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[Presentation] Reacitve oxygen species generated by NADPH oxidase contribute to ureteric bud branching and nephrogenesis2012
Author(s)
Matsuura S, Kondo S, Kinoshita Y, Suga K, Urushihara M, Kishi N, Nagai T, Jamba A, Kagami S
Organizer
Pediatric Academic societies annual meeting 2012
Place of Presentation
The Hynes Convention Center,Boston, USA
Related Report
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[Presentation] Urinary angiotensinogen as a biomarker of the intrarenal status of the renin-angiotensin system in patients with chronic glomerulonephritis2011
Author(s)
Urushihara M, Kinoshita Y, Matsuura S, Suga K, Takamatsu M, Shimizu M, Kondo S, Kobori H, Kagami S.
Organizer
11th Asian Congress of Pediatric Nephrology 2011
Place of Presentation
Fukuoka International Congress Center,Fukuoka,Japan
Related Report
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[Presentation] The role of NADPH oxidase (Nox) in ureteric bud branching and nephrogenesis2011
Author(s)
Matsuura S, Kondo S, Kinoshita Y, Suga K, Urushihara M, Takamatsu M, Shimizu M, Kishi N, Kagami S.
Organizer
11th Asian Congress of Pediatric Nephrology 2011
Place of Presentation
Fukuoka International Congress Center,Fukuoka,Japan
Related Report
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[Presentation] A case of membranous nephropathy and open angle glaucoma complicated with asymptomatic Siogren's syndrome2011
Author(s)
Matsuura S, Kondo S, Suga K, Kinoshita Y, Urushihara M, Takamatsu M, Shimizu M, Kishi N, Kagami S.
Organizer
11th Asian Congress of Pediatric Nephrology 2011
Place of Presentation
Fukuoka International Congress Center,Fukuoka,Japan
Related Report
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