The study of the neurological effects of GH therapy for SGA rats

• Project/Area Number: 23591594
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Nagoya University
• Principal Investigator: HAYAKAWA Masahiro 名古屋大学, 医学部附属病院, 病院教授 (40343206)
• Co-Investigator(Kenkyū-buntansha): OKUMURA Akihisa 順天堂大学, 医学部, 准教授 (60303624) ; SATO Yoshiaki 名古屋大学, 医学部附属病院, 講師 (30435862)
• Co-Investigator(Renkei-kenkyūsha): HATTORI Tetsuo 名古屋大学, 医学部附属病院, 医員 (00571324)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 胎児発育不全 / 中枢神経障害 / 行動評価 / 成長ホルモン

Research Abstract

Fetal growth restriction is one of the causes of small-for-gestational age (SGA). SGA is high risk of neurological sequelae in later life. Neonatologists have treated to SGA infants in order to prevent from neurological sequelae. However, those treatments were not always effective. In this study, SGA rats had poorer outcome for neurobehavioral tests during early and late infantile period. These findings iindicated that neurological development might be related with somatic growth. It is suggested that optimal postnatal care might be important in SGA infants in order to decrease morbidity.

Research Products

• [Journal Article] Pneumothoraces as a fatal complication of congenital diaphragmatic hernia in the era of gentle ventilation (2014)
  • Author(s): Usui N, Nagata K, Hayakawa M, Okuyama H, et al
  • Journal Title: Eur J Pediatr Surg Volume: 24(1) Issue: 01 Pages: 31-8
  • DOI: 10.1055/s-0033-1357753
  • Peer Reviewed
• [Journal Article] Effect of placenta previa on neonatal respiratory disorders and amniotic lamellar body counts at 36-38weeks of gestation (2014)
  • Author(s): Tsuda H, Kotani T, Sumigama S, Mano Y, Hua L, Hayakawa H, Hayakawa M, et al.
  • Journal Title: Early Hum Dev Volume: 90(1) Issue: 1 Pages: 51-4
  • DOI: 10.1016/j.earlhumdev.2013.10.005
  • Peer Reviewed
• [Journal Article] Neonatal M. Incidence and prediction of outcome in hypoxic-ischemic encephalopathy in Japan (2014)
  • Author(s): Hayakawa M, Ito Y, Saito S, Mitsuda N, et al.
  • Journal Title: Pediatr Int Volume: 56(2) Issue: 2 Pages: 215-21
  • DOI: 10.1111/ped.12233
  • Peer Reviewed
• [Journal Article] 新生児における再生医療/幹細胞療法 (2014)
  • Author(s): 早川昌弘
  • Journal Title: 日本未熟児新生児学会雑誌 Volume: 26巻1号 Pages: 44-46
• [Journal Article] Amniotic lamellar body count and congenital diaphragmatic hernia in humans and in a rat model. (2013)
  • Author(s): Watanabe Y, Tsuda H, Kotani T, Sumigama S, Mano Y, Hayakawa M, et al.
  • Journal Title: Pediatr Res Volume: 73 Issue: 3 Pages: 344-348
  • DOI: 10.1038/pr.2012.187
  • Peer Reviewed
• [Journal Article] Clinicoepidemiologic Status of Mother-to-Child Infections: A Nationwide Survey in Japan. (2013)
  • Author(s): Torii, Y, Kimura, H, Ito, Y, Hayakawa, M, Tanaka, T, Tajiri, H, Yoto, Y, Tanaka-Taya, K, Kanegane, H, Nariai, A, Sakata, H, Tsutsumi, H, Oda, M, Yokota, S, Morishima, T, Moriuchi, H
  • Journal Title: Pediatr Infect Dis J Volume: 32 Issue: 6 Pages: 699-701
  • DOI: 10.1097/inf.0b013e3182897c36
  • Peer Reviewed
• [Journal Article] Prognostic Factors of Congenital Diaphragmatic Hernia Accompanied by Cardiovascular Malformation (2013)
  • Author(s): Takahashi, S, Sago, H, Kanamori, Y, Hayakawa, M, Okuyama, H, Inamura, N, Fujino, Y, Usui, N, Taguchi, T
  • Journal Title: Pediatr Int Volume: 55 Issue: 4 Pages: 492-7
  • DOI: 10.1111/ped.12104
  • Peer Reviewed
• [Journal Article] The diameter of the inferior vena cava provides a noninvasive way of calculating central venous pressure in neonates (2013)
  • Author(s): Sato Y, Kawataki M, Hirakawa A, Toyoshima K, Kato T, Itani Y, Hayakawa M.
  • Journal Title: Acta Paediatr Volume: 102(6) Issue: 6
  • DOI: 10.1111/apa.12247
  • Peer Reviewed
• [Journal Article] The current profile and outcome of congenital diaphragmatic hernia: a nationwide survey in Japan. (2013)
  • Author(s): Nagata, K, Usui, N, Kanamori, Y, Takahashi, S, Hayakawa, M, Okuyama, H, Inamura, N, Fujino, Y, Taguchi, T
  • Journal Title: J Pediatr Surg Volume: 48 Issue: 4 Pages: 738-744
  • DOI: 10.1016/j.jpedsurg.2012.12.017
  • Peer Reviewed
• [Journal Article] Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan (2013)
  • Author(s): Ito Y, Kimura H, Torii Y, Hayakawa M, Tanaka T, Tajiri H, Yoto Y, Tanaka-Taya K, Kanegane H, Nariai A, Sakata H, Tsutsumi H, Oda M, Yokota S, Morishima T, Moriuchi H
  • Journal Title: Pediatr Int Volume: 55 Issue: 5 Pages: 566-571
  • DOI: 10.1111/ped.12122
  • Peer Reviewed
• [Journal Article] Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice (2013)
  • Author(s): D Ibi, I Nagai, A Nakajima, H Mizoguchi, T Kawase, D Tsuboi, S Kano, Y Sato, M Hayakawa, U. C. Lange, D. J. Adams, M. Azim Surani, T Satoh, A Sawa, K Kaibuchi, T Nabeshima and K Yamada
  • Journal Title: Glia Volume: 61 Issue: 5 Pages: 679-693
  • DOI: 10.1002/glia.22461
  • Peer Reviewed
• [Journal Article] The Effect of Hospital Volume on the Mortality of Congenital Diaphragmatic Hernia in Japan (2013)
  • Author(s): Hayakawa M, Ito M, Hattori T, Kanamori Y, Okuyama H, Inamura N, et al
  • Journal Title: Pediatr Int Volume: 印刷中 Issue: 2 Pages: 190-196
  • DOI: 10.1111/ped.12059
  • Peer Reviewed
• [Journal Article] 成熟児のasphyxiaとcerebral palsyその疫学と治療/予後低酸素性虚血性脳症の神経学的予後予測における慢性期MRIと経時的脳波所見の有用性について (2013)
  • Author(s): 林誠司、松沢要、山本ひかる、藤巻英彦、伊東真隆、加藤英子、安田彩子、加藤徹、早川昌弘
  • Journal Title: 周産期学シンポジウム Volume: 31号 Pages: 87-91
• [Journal Article] 成熟児のasphyxiaとcerebral palsyその疫学と治療/予後出生前・出生時は軽微な異常だが、遅発性・進行性の症状を呈する周産期脳障害 (2013)
  • Author(s): 佐藤義朗、岩田欧介、加藤徹、早川文雄、久保田哲夫、丸山幸一、長谷川正幸、大城誠、鬼頭修、奥村彰久、早川昌弘
  • Journal Title: 周産期学シンポジウム Volume: 31号 Pages: 83-86
• [Journal Article] 周産期学シンポジウムアンケート調査報告本邦における新生児低酸素性虚血性脳症の現状と病態に関する研究 (2013)
  • Author(s): 早川昌弘
  • Journal Title: 周産期学シンポジウム Volume: 31号 Pages: 23-27
• [Journal Article] Dexamethasone administration to the neonatal rat results in neurological dysfunction at the juvenile stage even at low doses. (2012)
  • Author(s): Ichinohashi Y, Sato Y, Saito A, Ito M, Watanabe K, Hayakawa M, Nakanishi K, Wakatsuki A, Oohira A.
  • Journal Title: Early Hum Dev. Volume: (Epub ahead of print) Issue: 5 Pages: 283-8
  • DOI: 10.1016/j.earlhumdev.2012.10.007
  • Peer Reviewed
• [Journal Article] Congenital pancreatoblastoma associated with beta-catenin mutation. (2012)
  • Author(s): Ismael O, Shimada A, Hama A, Takahashi Y, Sato Y, Hayakawa M, et al.
  • Journal Title: Pediatr Blood Cancer Volume: 58 Issue: 5 Pages: 827-827
  • DOI: 10.1002/pbc.23337
  • Peer Reviewed
• [Journal Article] 周産期脳障害の発症機序 (2012)
  • Author(s): 早川昌弘
  • Journal Title: 東海産婦人科学会誌 Volume: 48 Pages: 7-12
• [Journal Article] 【新生児医療-最近の進歩】 新生児医療におけるaEEGの有用性 (2012)
  • Author(s): 早川昌弘
  • Journal Title: 医学のあゆみ Volume: 240 Pages: 221-224
• [Journal Article] Carbohydrate and energy metabolism in the brain of rats with thromboxane A2-induced fetal growth restriction (2011)
  • Author(s): Hayakawa M, Sato Y, Hattori T, Ichinohashi Y, Nakayama A, Yamamoto H, et al.
  • Journal Title: Pediatr Res Volume: 70 Pages: 21-24
  • Peer Reviewed
• [Journal Article] Transmission of cytomegalovirus via breast milk in extremely premature infants (2011)
  • Author(s): Hayashi S, Kimura H, Oshiro M, Kato Y, Yasuda A, Suzuki C, Watanabe, Y. Morishima, T. Hayakawa, M
  • Journal Title: J Perinatol Volume: 31 Pages: 440-445
  • Peer Reviewed
• [Journal Article] Amplitude-integrated electroencephalography in preterm infants with cystic periventricular leukomalacia (2011)
  • Author(s): Kato T, Okumura A, Hayakawa F, Tsuji T, Natsume J, Hayakawa M
  • Journal Title: Early Hum Dev Volume: 87 Pages: 217-212
  • Peer Reviewed
• [Journal Article] Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN) (2011)
  • Author(s): Tsuda H, Takahashi Y, Iwagaki S, Uchida Y, Kawabata I, Hayakawa M, et al
  • Journal Title: J Perinat Med Volume: 39 Pages: 245-50
  • Peer Reviewed
• [Journal Article] Congenital pancreatoblastoma associated with beta-catenin mutation (2011)
  • Author(s): Ismael O, Shimada A, Hama A, Takahashi Y, Sato Y, Hayakawa M, et al
  • Journal Title: Pediatr Blood Cance Volume: 58 Pages: 827-827
  • Peer Reviewed
• [Journal Article] 【最新 胎児・新生児のNeurology-評価・治療・予防法の進歩と気になる病態】 周産期の評価 新生児頭部エコー (2011)
  • Author(s): 兵藤玲奈, 佐藤義朗, 早川昌弘
  • Journal Title: 周産期医学 Volume: 41 Pages: 1435-1440
• [Journal Article] 【How to Follow-up Q&A-フォローアップのコツすべて教えます】 神経学的評価 画像・脳波・聴力検査等いつ頃何を検査したらよいでしょうか? (2011)
  • Author(s): 杉山裕一朗, 早川昌弘
  • Journal Title: 周産期医学 Volume: 41 Pages: 1034-1036
• [Journal Article] 【どこまでもやさしく!臨床に役立つ新生児の解剖・生理・生化学】 神経系 神経の解剖・生理・生化学 (2011)
  • Author(s): 早川昌弘
  • Journal Title: 小児看護 Volume: 34 Pages: 1420-1427
• [Journal Article] 佐藤義朗, 中西圭子, 服部哲夫, 一ノ橋祐子, Blomgren Klas, 大平敦彦, 早川昌弘 (2011)
  • Author(s): 周産期脳障害と向き合うために 分野を超えた専門知識の相互リンクがもたらすもの 中枢神経疾患に対する幹細胞療法 周産期脳障害の救世主となりうるか
  • Journal Title: 脳と発達 Volume: 43 Pages: 201-205
• [Journal Article] 一ノ橋祐子, 早川昌弘 (2011)
  • Author(s): 【どんな異常も見逃さない! 産科急変のシグナルとベスト対応】 新生児 仮死出生 羊水の胎便混濁あり・なし
  • Journal Title: ペリネイタルケア Volume: 新春増刊 Pages: 81-92
• [Journal Article] 早川昌弘 (2011)
  • Author(s): 【新生児医療の最前線 産婦人科医が知っておきたい新生児の新知識】 新生児脳波 その基本と最新の知見
  • Journal Title: 産婦人科治療 Volume: 105 Pages: 335-339
• [Journal Article] 河村江里子, 村松智美, 豊留有香, 早川昌弘 (2011)
  • Author(s): 【新生児看護に重要となる症状・疾患のケア「発見→診断→治療」と看護のポイント】 「発見→診断→治療」と看護ケア 新生児発作の看護ポイント
  • Journal Title: 小児看護 Volume: 33 Pages: 1663-1668
• [Journal Article] 服部哲夫, 早川昌弘 (2011)
  • Author(s): 【新生児看護に重要となる症状・疾患のケア「発見→診断→治療」と看護のポイント】 「発見→診断→治療」と看護ケア 新生児発作
  • Journal Title: 小児看護 Volume: 33 Pages: 1656-1662
• [Presentation] Preterm児のCP～Late preterm児(34～36週)の低酸素性虚血性脳症～ (2014)
  • Author(s): 早川昌弘
  • Organizer: 第32回周産期学シンポジウム
  • Place of Presentation: 九州大学百年講堂(福岡市)
  • Invited
• [Presentation] Preterm児のCP Late preterm児(34～36週)の低酸素性虚血性脳症 (2014)
  • Author(s): 早川昌弘
  • Organizer: 第32回周産期学シンポジウム
  • Place of Presentation: 九州大学百年講堂（福岡市）
  • Invited
• [Presentation] Incidence and prediction of outcome in hypoxic-ischemic encephalopathy in Japan (2013)
  • Author(s): Hayakawa M, Ito Y, Saito S, Mitsuda N, Hosono S, Yoda H, et al
  • Organizer: Hottpoics in Neonatology 2013
  • Place of Presentation: Washington DC, USA
• [Presentation] 新生児における再生医療/幹細胞療法 (2013)
  • Author(s): 早川昌弘
  • Organizer: 第58回日本未熟児新生児学会
  • Place of Presentation: 石川県立音楽堂(金沢市)
  • Invited
• [Presentation] 本邦における新生児低酸素性虚血性脳症の現状と病態に関する研究 (2013)
  • Author(s): 早川昌弘
  • Organizer: 第31回周産期学シンポジウム
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Invited
• [Presentation] Incidence and prediction of outcome in hypoxic-ischemic encephalopathy in Japan (2013)
  • Author(s): Hayakawa, M, Ito, Y, Saito, S, Mitsuda, N, Hosono, S, Yoda, H, Cho, K, Otsuki, K, Ibara, S, Terui, K, Masumoto, K, Murakoshi, T, Nakai, A, Tanaka, M, Nakamura, T.
  • Organizer: Hottpoics in Neonatology 2014
  • Place of Presentation: Washington DC, USA
• [Presentation] 新生児における再生医療/幹細胞療法 (2013)
  • Author(s): 早川昌弘
  • Organizer: 第58回日本未熟児新生児学会
  • Place of Presentation: 石川県立音楽堂（金沢市）
  • Invited
• [Presentation] 本邦における新生児低酸素性虚血性脳症の現状と病態に関する研究 (2013)
  • Author(s): 早川昌弘
  • Organizer: 第31回周産期学シンポジウム
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Invited
• [Presentation] 新生児の診断・治療up to date新生児医療における脳機能モニタリングの活用 (2012)
  • Author(s): 早川昌弘
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡市)
  • Invited
• [Presentation] 先天性横隔膜ヘルニアにおける心エコー検査の再評価 わが国における全国調査より (2012)
  • Author(s): 早川 昌弘, 臼井 規朗, 稲村 昇, 奥山 宏臣, 金森 豊, 高橋 重裕, 田口 智章, 藤野 裕士
  • Organizer: 第48回日本周産期・新生児医学会学術集会
  • Place of Presentation: 大宮ソニックシティ（大宮市）
• [Presentation] 新生児の診断・治療up to date 新生児医療における脳機能モニタリングの活用 (2012)
  • Author(s): 早川昌弘
  • Organizer: 第116回日本小児科学会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Invited
• [Presentation] 長期予後からみた出生前診断症例における周産期管理の再評価：当院における先天性横隔膜ヘルニアの合併症と予後 (2012)
  • Author(s): 伊藤美春、早川昌弘
  • Organizer: 第30回周産期学シンポジウム
  • Place of Presentation: 東京
• [Presentation] Nationwide Survey on the Current State of Congenital Diaphragmatic Hernias in Japan (2011)
  • Author(s): Hayakawa M, Usui N, Kanamori Y, Okuyama H, Inamura N, TakahashiS, Fujino Y, Taguchi T
  • Organizer: Hot topic in Neonatology 2011
  • Place of Presentation: Washington DC, USA
• [Presentation] Nationwide Survey on the Current State of Congenital Diaphragmatic Hernias in Japan (2011)
  • Author(s): Masahiro Hayakawa, Noriaki Usui, Yutaka Kanamori, Hiroomi Okuyam, Noboru Inamura, Shigehiro Takahashｉ, Yuji Fujino, Tomoaki Taguchi
  • Organizer: Hot topic in Neonatology 2011
  • Place of Presentation: Washington,DC
• [Book] 今日の小児治療指針第15版 新生児頭蓋内出血 (2012)
  • Author(s): 早川昌弘
  • Total Pages: 1
  • Publisher: 医学書院
• [Remarks] ホームページ
  • URL: http://www.med.nagoya-u.ac.jp/medical/6391/6444/shuusanboshiigaku.html