Evaluation of Plasma Concentration of the Antiarrhythmic Agent for Treatment of Fetus Tachycardia
| Project/Area Number |
23591607
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kinki University |
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Principal Investigator |
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| Research Collaborator |
KATSURAGI Shinji
IKEDA Tomoaki
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 胎児不整脈 / 抗不整脈薬 / 薬物血中濃度 / 経胎盤的胎児治療 |
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| Outline of Final Research Achievements |
This study was conducted in 32 hospitalized patients (average age 31.2, average weight 59.0) to investigate pharmacokinetics and pharmacodynamic. The mean cord blood/maternal plasma concentration of DX (16 examples) and ST (7 examples) was 67.6% and 73.9%, respectively.As for the dosage, a correlation was found in both DX plasma concentrations (26 examples) (P<0.001) and ST plasma concentration (12 examples) (P=0.04). There was a correlation tendency between DX plasma concentration and serum creatinine (Scr) (P=0.06), was not a significant correlation between ST plasma concentration and Scr (P=0.18). Furthermore, maternal heart rate related to DX plasma concentration weakly (P=0.09), but did not relate to ST plasma concentration (P=0.51). Treatment of fetus tachycardia made fetal atrial heart rate decreased like log approximation.
It is expected to apply for approval of health insurance treatment by analyzing more additional target cases.
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Report
(6 results)
Research Products
(1 results)
