Immunological effects of Ureaplasma parvum on pregnancy outcome in mice.
| Project/Area Number |
23591609
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Research Institute, Osaka Medical Center for Maternal and Child Health |
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Principal Investigator |
ITARU Yanagihara 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, その他 (60314415)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAHIRA Kumiko 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), 免疫部門, 流動研究員 (20581317)
NISHIUMI Fumiko 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), 免疫部門, 流動研究員 (60599596)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 早産 / 周産期感染症 / ウレアプラズマ / 病原因子 / ゲノム解析 / 粘膜ワクチン / 早産ワクチン開発 / ワクチン |
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| Research Abstract |
Ureaplasma spp. are members of the family Mycoplasmataceae and have been considered to be associated with chorioamnionitis and preterm delivery. We purified multiple-banded antigen (MBA) from U. parvum, and synthesized N-terminal diacylated lipopeptide of MBA, UPM-1. Using luciferase assays, both purified MBA and UPM-1 activated the NF-kB pathway via TLR2 in vitro. The intrauterine MBA injection on day 15 of gestation on pregnant C3H/HeN mice group had a significantly higher incidence of intrauterine fetal death (IUFD; 38.5%). Intrauterine injection of UPM-1 caused preterm deliveries (80.0%). The placentas of the UPM-1 injection group showed neutrophil infiltration. We also reported the complete genome sequence of Ureaplasma parvum serovar 3, clinical strain SV3F4, isolated from a Japanese patient with a history of an infectious abortion.
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Report
(4 results)
Research Products
(78 results)
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[Journal Article] Complete Genome Sequence of Ureaplasma parvum Serovar 3 Strain SV3F4, Isolated in Japan2014
Author(s)
Wu HN, Nakura Y, Motooka D, Nakamura S, Nishiumi F, Ishino S, Kawai Y, Tanaka T, Takeuchi M, Nakayama M, Fujita T, Yanagihara I
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Journal Title
Genome Announc
Volume: 2(3)
Issue: 3
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effects of Ureaplasma parvum lipoprotein multiple-banded antigen on pregnancy outcome in mice.2013
Author(s)
Uchida K, Nakahira K, Mimura K, Shimizu T, De Seta F, Wakimoto T, Kawai Y, Nomiyama M, Kuwano K, Guaschino S, Yanagihara I.
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Journal Title
J Reprod Immunol.
Volume: 100(2)
Issue: 2
Pages: 118-127
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment and characterization of Roberts Syndrome and SC phocomelia model medaka, Oryzias latipes2012
Author(s)
Morita A, Nakahira K, Hasegawa T, Uchida K, Taniguchi Y, Takeda S, Toyoda A, Sakaki Y, Shimada A, Takeda H, Yanagihara I
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Journal Title
Dev Growth Differ
Volume: 54(5)
Issue: 5
Pages: 588-604
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin | locus.2012
Author(s)
Sakamoto, S., ffakae, K., Anzai, Y., Murai, K., Tamaki, N., Miyazaki, M., Miyazaki, K., Romanow, W. J., Ikawa, T., Kitamura, D., Yanagihira, I., Minato, N., Murre, C., Agata, Y
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Journal Title
J. Immunol
Volume: 188
Issue: 11
Pages: 5547-5560
DOI
Related Report
Peer Reviewed
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[Journal Article] Polymorphism in annexin A5 gene promoter in Japanese women with recurrent pregnancy loss2011
Author(s)
Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H
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Journal Title
Mol Hum Reprod
Volume: 17
Issue: 7
Pages: 447-452
DOI
Related Report
Peer Reviewed
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[Journal Article] Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss.2011
Author(s)
Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, Fujita T, Imayoshi Y, Markoff A, Yanagihara I, Udagawa Y, Kurahashi H
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Journal Title
Mol Hum Reprod
Volume: 17(7)
Pages: 447-452
Related Report
Peer Reviewed
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[Presentation] Obstetric complication-associated ANXA5 promoter polymorphisms affect gene expression via DNA secondary structures2012
Author(s)
Hideto Inagaki, Sayuri Ota, Haruki Nishizawa, Hironori Miyamura, Kumiko Nakahira, Machiko Suzuki, Sachie Nishiyama, Yasuhiro Udagawa, Itaru Yanagihara, Hiroki Kurahashi,
Organizer
American Society of Human Genetics
Place of Presentation
サンフランシスコ
Related Report
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[Presentation] Virulence factorsofUreaplasma parvum2011
Author(s)
Itaru Yanagihara, Kaoru Uchida, Kumiko Nakahira and Fumiko Nishiumi
Organizer
Joint Congress of The 5^<th> Meeting of Asian Organization for Mycoplasmology. The 38^<th> Meeting of the Japanese Society of Mycoplasmology
Place of Presentation
Nagasaki
Related Report
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[Presentation] Virulence factors of Ureaplasma parvum2011
Author(s)
Kumiko Nakahira, Kaoru Uchida, and Fumiko Nishiumi, ItaruYanagihara
Organizer
Joint Congress of The 5th Meeting of Asian Organization for Mycoplasmology. The 38th Meeting of the Japanese Society of Mycoplasmology(招待講演)
Place of Presentation
Nagasaki
Related Report
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