| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study I have focused on the chiral-specific action of neutral amino acids especially D-serine, a coagonist of NMDA type glutamate receptor, in the central nervous system to further understand pathophysiology of schizophrenia and to develop novel therapeutics. During the genetic study I have found some of the D-serine-NMDA receptor signal-related genes are associated with schizophrenia. In this study focusing on the chiral-specific agonistic action of neutral amino acids as well as the NMDA receptor antagonism by PCP, I further obtained some evidence that indicated possible heterogeneity of the disease-vulnerability based on the gender- and age of onset-stratified genetic approach.
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