A study of treatment strategies for obsessive-compulsive disorder by using cognitive performance and functional neuroimagings
| Project/Area Number |
23591709
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SUMITANI Satsuki 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (90346594)
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Masafumi 徳島大学, 大学院ヘルスバイオサイエンス, 教授 (20228654)
TOMOTAKE Masahito 徳島大学, 大学院ヘルスバイオサイエンス, 教授 (50294682)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 強迫性障害 / 認知機能 / 機能画像 / 前頭葉 / 基底核 / NIRS / MRS / 前頭葉機能 / GABA / 脳血流 / Stroop Test / グルタミン酸 |
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| Research Abstract |
We studied to find strategies for obsessive compulsive disorder(OCD) by using cognitive performance and functional neuroimagings. We found abnormalities of metabolites of right basal ganglia of OCD patients by using 3 tesla proton magnetic resonance spectroscopy (MRS). Moreover we found a significantly lower cognitive performance and a hypofrontality of OCD patients by using multichannel NIRS compared to control group. It is suggested that we might choose strategies for OCD patients who have different biological feature individually.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Meta-analyses of Blood Homocysteine Levels for Gender and Genetic Association Studies of the MTHFR C677T Polymorphism in Schizophrenia2014
Author(s)
Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, Tomotake M, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T
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Journal Title
Schizophr Bull
Volume: (Epub ahead of print)
Related Report
Peer Reviewed
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[Journal Article] Clinical correlates associated with cognitive dysfunction in people with schizophrenia2012
Author(s)
Tanaka T, Tomotake M, Ueoka Y, Kaneda Y, Taniguchi K, Nakataki M, Numata S, Tayoshi S, Yamauchi K, Sumitani S, Ohmori T, Ueno S, Ohmori T
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Journal Title
Psychiatry Clin Neurosci
Volume: 66
Pages: 491-498
Related Report
Peer Reviewed
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[Journal Article] Criterion and construct validity of the CogState Schizophrenia Battery in Japanese patients with schizophrenia2011
Author(s)
Yoshida T, Suga M, Arima K, Muranaka Y, Tanaka T, Eguchi S, Lin C, Yoshida S, Ishikawa M, Higuchi Y, Seo T, Ueoka Y, Tomotake M, Kaneda Y, Darby D, Maruff P, Iyo M, Kasai K, Higuchi T, Sumiyoshi T, Ohmori T, Takahashi K, Hashimoto K
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Journal Title
PLoS One
Volume: Vol.6
Issue: 5
Pages: e20469-e20469
DOI
Related Report
Peer Reviewed
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[Journal Article] Quality of life and cognitive dysfunction in people with schizophrenia2011
Author(s)
Ueoka Y, Tomotake M, Tanaka T, Kaneda Y, Taniguchi K, Nakataki M, Numata S, Tayoshi S, Yamauchi K, Sumitani S, Ohmori T, Ueno S, Ohmori T
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 15 ; 35(1)
Issue: 1
Pages: 53-9
DOI
Related Report
Peer Reviewed
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[Presentation] メンタルヘルスと栄養2012
Author(s)
住谷さつき
Organizer
第244回徳島医学会学術集会
Place of Presentation
長井記念ホール(徳島県) (シンポジウム)
Year and Date
2012-02-12
Related Report
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