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neural basis of derangement of ego in schizophrenia

Research Project

Project/Area Number 23591712
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

ONITSUKA Toshiaki  九州大学, 大学病院, 講師 (00398059)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords統合失調症 / 脳磁図 / MRI / 自我障害 / 双極性障害 / MRI
Research Abstract

The current study investigated the visually evoked oscillations for subject's family name using magnetoencephalography (MEG). Twenty SZ patients and 20 normal controls (NC) participated in this study. The MEG signals were acquired using a whole-head, 306-channel sensor array. In this study, we presented visually four types of Japanese character string (kana): (1) subject's family name (30%), (2) another family name (30%), (3) meaningless string (30%), (4) a Japanese city name (target, 10%). In the mean power of evoked high gamma oscillations between 190msec and 210msec after stimulus onset, a repeated measures ANOVA demonstrated significant stimulus-by-group interactions. In post-hoc analyses, NC showed a significant difference (subject's family name>another family name>meaning less string), but there was no significant stimulus effect in SZ. The high gamma frequency neural oscillatory abnormalities of SZ may indicate a new evidence for neural basis of derangement of ego.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (61 results)

All 2014 2013 2012 2011 Other

All Journal Article (25 results) (of which Peer Reviewed: 7 results) Presentation (24 results) (of which Invited: 2 results) Book (11 results) Remarks (1 results)

  • [Journal Article] Preattentive dysfunction in patients with bipolar disorder as revealed by the pitch-mismatch negativity: an MEG study2014

    • Author(s)
      Shimano S, Onitsuka T, Oribe N, Maekawa T, Tsuchimoto R, Hirano S, Ueno T, Hirano Y, Miura T, Kanba S
    • Journal Title

      Bipolar Disord

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurophysiological findings in patients with bipolar disorder2013

    • Author(s)
      Onitsuka T, Oribe N, Kanba S
    • Journal Title

      Suppl Clin Neurophysiol

      Volume: 62 Pages: 197-206

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Altered visual predictive systems in bipolar disorder : evidence from visual MMN and P3002013

    • Author(s)
      Maekawa T, Katsuki S, Kishimoto J, Onitsuka T, Ogata K, Yamasaki T, Ueno T, Tobimatsu S, Kanba S
    • Journal Title

      Front Hum Neurosci

      Volume: 26 Pages: 403-403

    • DOI

      10.3389/fnhum.2013.00403

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A review of neurophysiological findings in patients with schizophrenia2013

    • Author(s)
      Onitsuka T, Oribe N, Nakamura I, Kanba S
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 67 Pages: 461-470

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] 統合失調症の脳生理学的研究の進歩2013

    • Author(s)
      鬼塚俊明
    • Journal Title

      精神神経学雑誌

      Volume: 115 Pages: 847-852

    • NAID

      10031195477

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Altered visual information processing systems in bipolar disorder: evidence from visual MMN and P32013

    • Author(s)
      Maekawa T, Katsuki S, Kishimoto J, Onitsuka T, Ogata K, Yamasaki T, Ueno T, Tobimatsu S, Kanba S
    • Journal Title

      Front Hum Neurosci

      Volume: 7 Pages: 403-403

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients2012

    • Author(s)
      Oda Y, Onitsuka T, Tsuchimoto R, Hirano S, Oribe N, Ueno T, Hirano Y, Nakamura I, Miura T, Kanba S
    • Journal Title

      PLoS ONE

      Volume: 7 (7)

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Auditory and visual mismatch negativity in psychiatric disorders : a review2012

    • Author(s)
      Maekawa T, Hirano S, Onitsuka T
    • Journal Title

      Current Psychiatry Reviews

      Volume: 8 Pages: 97-105

    • Related Report
      2013 Final Research Report
  • [Journal Article] Altered face inversion effect and association between face N170 reduction and social dysfunction in patients with schizophrenia2012

    • Author(s)
      Tsunoda T, Kanba S, Ueno T, Hirano Y, Hirano S, Maekawa T, Onitsuka T
    • Journal Title

      Clin Neurophysiol

      Volume: 123 Pages: 1762-1768

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Emotional face processing impairments and their association with personality traits in schizophrenia : an event-related potential study2012

    • Author(s)
      Kirihara K, Kasai K, Tada M, Nagai T, Kawakubo Y, Yamasaki S, Onitsuka T, Araki T
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 37 Pages: 270-275

    • Related Report
      2013 Final Research Report
  • [Journal Article] 脳波で何がわかるか-統合失調症2012

    • Author(s)
      角田智哉、鬼塚俊明
    • Journal Title

      精神科

      Volume: 20 Pages: 56-62

    • Related Report
      2013 Final Research Report
  • [Journal Article] 内因性精神疾患におけるneural oscillationとGABA2012

    • Author(s)
      土本利架子、鬼塚俊明、神庭重信
    • Journal Title

      Clinical Neuroscience

      Volume: 30 Pages: 1422-1424

    • Related Report
      2013 Final Research Report
  • [Journal Article] 精神疾患の脳画像研究2012

    • Author(s)
      鬼塚俊明
    • Journal Title

      臨床神経学

      Volume: 52 Pages: 1376-1378

    • NAID

      130004505168

    • Related Report
      2013 Final Research Report
  • [Journal Article] Auditory and visual mismatch negativity in psychiatric disorders: a review2012

    • Author(s)
      Maekawa T, Hirano S, Onitsuka T
    • Journal Title

      Current Psychiatry Reviews

      Volume: 8 Issue: 2 Pages: 97-105

    • DOI

      10.2174/1573400511208020097

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neurophysiological impairment in emotional face processing is associated with low extraversion in schizophrenia.2012

    • Author(s)
      Kirihara K, Kasai K, Tada M, Nagai T, Kawakubo Y, Yamasaki S, Onitsuka T, Araki T.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry.

      Volume: 37 Issue: 2 Pages: 270-275

    • DOI

      10.1016/j.pnpbp.2012.02.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 脳波で何がわかるか-統合失調症2012

    • Author(s)
      角田智哉、鬼塚俊明
    • Journal Title

      精神科

      Volume: 20 Pages: 56-62

    • Related Report
      2012 Research-status Report
  • [Journal Article] Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia2011

    • Author(s)
      Tsuchimoto R, Kanba S, Hirano S, Oribe N, Ueno T, Hirano Y, Nakamura I, Oda Y, Miura T, Onitsuka T
    • Journal Title

      Schizophr Res

      Volume: 133 Pages: 99-105

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] Neuroanatomical and neurophysiological abnormalities in the neural correlates of face processing in schizophrenia2011

    • Author(s)
      Onitsuka T
    • Journal Title

      Current Psychiatry Reviews

      Volume: 7 Pages: 322-328

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] 統合失調症の顔認知障害と社会機能障害の関連2011

    • Author(s)
      鬼塚俊明、大林長二、角田智哉、平野昭吾、平野羊嗣、前川敏彦、上野雄文
    • Journal Title

      認知神経科学

      Volume: 13 Pages: 64-70

    • NAID

      130006895660

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] 双極性障害の脳画像と神経生理学2011

    • Author(s)
      織部直弥、鬼塚俊明、神庭重信
    • Journal Title

      臨床精神医学

      Volume: 40 Pages: 299-305

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] 精神疾患と脳磁図2011

    • Author(s)
      織部直弥、鬼塚俊明
    • Journal Title

      最新精神医学

      Volume: 16 Pages: 287-291

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] Top-down and bottom-up visual information processing of non-social stimuli in high-functioning autism spectrum disorder2011

    • Author(s)
      Maekawa T, Tobimatsu S, Inada N, Oribe N, Onitsuka T, Kanba S, Kamio Y
    • Journal Title

      Res Autism Spectr Disord

      Volume: 5 Pages: 201-209

    • NAID

      120004951562

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stability of the Rayleigh distribution2011

    • Author(s)
      Ueno T, Hirano S, Hirano Y, Oribe N, Nakamura I, Oda Y, Kanba S, Onitsuka T
    • Journal Title

      Proc International Cong Imaging Signal Processing IEEE

      Volume: 10 Pages: 2402-2403

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preattentive dysfunction in patients with bipolar disorder as revealed by the pitch-mismatch negativity : an MEG study

    • Author(s)
      Shimano S, Onitsuka T, Oribe N, Maekawa T, Tsuchimoto R, Hirano S, Ueno T, Hirano Y, Miura T, Kanba S
    • Journal Title

      Bipolar Disord

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 精神科領域におけるNeural oscillation研究

    • Author(s)
      鬼塚俊明、Uhlhaas PJ、多田真理子、Spencer KM、平野羊嗣、McCarley RW
    • Journal Title

      日本生物学的精神医学会誌

      Volume: (印刷中)

    • NAID

      130005395545

    • Related Report
      2013 Final Research Report
  • [Presentation] Neural dynamics in patients with schizophrenia and bipolar disorder : differences and similarities2013

    • Author(s)
      Onitsuka T, Oda Y, Tsuchimoto R, Kanba S
    • Organizer
      International Society for Advancement of Clinical MEG 2013
    • Place of Presentation
      Sapporo (Symposium)
    • Year and Date
      2013-08-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Auditory steady-state responses in schizophrenia and bipolar disorder2013

    • Author(s)
      Onitsuka T (Co-Chair)
    • Organizer
      11^<th> World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto (Symposium)
    • Year and Date
      2013-06-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 統合失調症の脳生理学的研究の進歩2013

    • Author(s)
      鬼塚俊明
    • Organizer
      第109回日本精神神経学会学術総会
    • Place of Presentation
      福岡市 (シンポジウム)
    • Related Report
      2013 Final Research Report
  • [Presentation] Electrophysiological and anatomical evidence for two distinct but interacting neural circuit abnormalities in the auditory cortex in schizophrenia2013

    • Author(s)
      Hirano Y, Oribe N, Kanba S, Onitsuka T, Hosokawa T, Shenton ME, McCarley RW, Spencer KM
    • Organizer
      American College of Neuropsychopharmacology (ACNP) 52st Annual Meeting
    • Place of Presentation
      Hollywood, FL, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 統合失調症の視覚ミスマッチ誘発磁場反応2013

    • Author(s)
      前川敏彦, 中村一太, 小原尚利, 小田祐子, 鬼塚俊明, 浦川智和, 飛松省三, 神庭重信
    • Organizer
      第28回日本生体磁気学会
    • Place of Presentation
      新潟市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 双極性障害の視覚予期システム異常:視覚ミスマッチ陰性電位とP300研究2013

    • Author(s)
      勝木聡美, 前川敏彦, 鬼塚俊明, 飛松省三, 神庭重信
    • Organizer
      第10回日本うつ病学会
    • Place of Presentation
      北九州市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Abnormal face-voice integration in schizophrenia: A magnetoencephalography study2013

    • Author(s)
      Nakamura I, Hirano Y, Kanba S, Onitsuka T
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] 統合失調症における視覚認知障害 自己関連刺激に対する脳磁図研究2013

    • Author(s)
      小原尚利, 小田祐子, 平野昭吾, 中村一太, 織部直弥, 土本利架子, 上野雄文, 前川俊彦, 平野羊嗣, 勝木聡美, 神庭重信, 鬼塚俊明
    • Organizer
      第109回日本精神神経学会学術総会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Auditory steady-state responses in schizophrenia and bipolar disorder2013

    • Author(s)
      Onitsuka T
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neural dynamics in patients with schizophrenia and bipolar disorder: differences and similarities2013

    • Author(s)
      Onitsuka T, Oda Y, Tsuchimoto R, Kanba S
    • Organizer
      International Society for Advancement of Clinical MEG 2013
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 統合失調症の脳生理学的研究の進歩2013

    • Author(s)
      鬼塚俊明
    • Organizer
      第109回日本精神神経学会学術総会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] バイオロジカルマーカー研究からDSM-5-神経生理学的検査による精神疾患診断は可能か?2012

    • Author(s)
      鬼塚俊明、平野羊嗣、平野昭吾、上野雄文、神庭重信 (シンポジスト)
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸市
    • Year and Date
      2012-09-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 統合失調症におけるGABA機能障害-神経生理学的研究-2012

    • Author(s)
      鬼塚俊明 (シンポジスト)
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸市
    • Year and Date
      2012-09-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Neural dynamics in patients with bipolar disorder and schizophrenia : differences and similarities2012

    • Author(s)
      Onitsuka T, Oda Y, Tsuchimoto R, Kanba S
    • Organizer
      The 2nd Meeting of East Asian Bipolar Forum
    • Place of Presentation
      Fukuoka, Japan (Symposium)
    • Year and Date
      2012-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 統合失調症の脳画像研究(神経学と精神医学の境界を再度超える)2012

    • Author(s)
      鬼塚俊明
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京都 (シンポジウム)
    • Year and Date
      2012-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] :統合失調症の脳画像研究(シンポジウム、神経学と精神医学の境界を再度超える)2012

    • Author(s)
      鬼塚俊明
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] バイオロジカルマーカー研究からDSM-V-神経生理学的検査による精神疾患診断は可能か?2012

    • Author(s)
      鬼塚俊明、平野羊嗣、平野昭吾、上野雄文、神庭重信
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸市
    • Related Report
      2012 Research-status Report
  • [Presentation] 統合失調症におけるGABA機能障害-神経生理学的研究-2012

    • Author(s)
      鬼塚俊明
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸市
    • Related Report
      2012 Research-status Report
  • [Presentation] 精神疾患のneural oscillation研究2011

    • Author(s)
      鬼塚俊明 (シンポジスト)
    • Organizer
      第41回日本臨床神経生理学会
    • Place of Presentation
      静岡市
    • Year and Date
      2011-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Reduced high and low frequency gamma synchronisation and auditory hallucinations in schizophrenia2011

    • Author(s)
      Onitsuka T
    • Organizer
      2nd Asian Neuropsychopharmacology Meeting
    • Place of Presentation
      Seoul, Korea (Symposium)
    • Year and Date
      2011-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Association between face N170 abnormalities and social dysfunction in schizophrenia2011

    • Author(s)
      Onitsuka T
    • Organizer
      10^<th> World Congress of Biological Psychiatry
    • Place of Presentation
      Plague, Czech Republic
    • Year and Date
      2011-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Association between face N170 abnormalities and social dysfunction in schizophrenia2011

    • Author(s)
      Onitsuka T
    • Organizer
      10th World Congress of Biological Psychiatry
    • Place of Presentation
      Plague, Czech Republic
    • Related Report
      2011 Research-status Report
  • [Presentation] Reduced high and low frequency gamma synchronisation and auditory hallucinations in schizophrenia2011

    • Author(s)
      Onitsuka T
    • Organizer
      2nd Asian Neuropsychopharmacology Meeting(招待講演)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Research-status Report
  • [Presentation] 精神疾患のneural oscillation研究2011

    • Author(s)
      鬼塚俊明
    • Organizer
      第41回日本臨床神経生理学会(招待講演)
    • Place of Presentation
      静岡市
    • Related Report
      2011 Research-status Report
  • [Book] EEG.脳画像と精神神経疾患2013

    • Author(s)
      前川敏彦、鬼塚俊明 (松田博史、山内俊雄編)
    • Publisher
      新興医学出版社、東京
    • Related Report
      2013 Final Research Report
  • [Book] 神経生理学.統合失調症2013

    • Author(s)
      鬼塚俊明、角田智哉 (福田正人、糸川昌成、村井俊哉、笠井清登編)
    • Publisher
      医学書院、東京
    • Related Report
      2013 Final Research Report
  • [Book] EEG(誘発電位, 脳電図を含む).脳画像でみる精神疾患2013

    • Author(s)
      前川敏彦, 鬼塚俊明
    • Total Pages
      16
    • Publisher
      新興医学出版社
    • Related Report
      2013 Annual Research Report
  • [Book] 神経生理学. 統合失調症2013

    • Author(s)
      鬼塚俊明, 角田智哉
    • Total Pages
      7
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] ガンマ・オシレーションと精神疾患.精神疾患診断のための脳形態・機能検査法2012

    • Author(s)
      鬼塚俊明 (三國雅彦、福田正人、功刀浩編)
    • Publisher
      新興医学出版社、東京
    • Related Report
      2013 Final Research Report
  • [Book] 精神疾患診断のための脳形態・機能検査法. 三國雅彦、福田正人、功刀浩編2012

    • Author(s)
      鬼塚俊明
    • Publisher
      ガンマ・オシレーションと精神疾患
    • Related Report
      2012 Research-status Report
  • [Book] New findings for face processing deficits in the mental disorder of schizophrenia. Face Analysis, Modeling and Recognition Systems2011

    • Author(s)
      Onitsuka T, Tsunoda T, Ohara N (Tudor Barbu (Ed.))
    • Publisher
      InTech
    • Related Report
      2013 Final Research Report
  • [Book] Neural oscillationを指標とした双極性障害の脳機能研究.精神疾患と認知機能-最近の進歩2011

    • Author(s)
      織部直弥、鬼塚俊明、神庭重信
    • Publisher
      新興医学出版社、東京
    • Related Report
      2013 Final Research Report
  • [Book] New findings for face processing deficits in the mental disorder of schizophrenia. Face Analysis, Modeling and Recognition Systems.2011

    • Author(s)
      Onitsuka T, Tsunoda T, Ohara N
    • Publisher
      InTech
    • Related Report
      2011 Research-status Report
  • [Book] 脳磁図: 精神医学キーワード事典2011

    • Author(s)
      鬼塚俊明
    • Publisher
      中山書店
    • Related Report
      2011 Research-status Report
  • [Book] 現代精神医学辞典(分担、編集協力者)2011

    • Author(s)
      鬼塚俊明
    • Publisher
      弘文堂
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.med.kyushu-u.ac.jp/psychiatry/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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