| Project/Area Number |
23591789
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
SASAKI Makoto 岩手医科大学, 医学部, 教授 (80205864)
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| Co-Investigator(Kenkyū-buntansha) |
TERAYAMA Yasuo 岩手医科大学, 医学部, 教授 (70146596)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | MRI / 血管壁 / 頭蓋内動脈 / 動脈硬化 / 動脈解離 |
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| Research Abstract |
We attempted to evaluate intracranial arterial wall lesions by using a T1-weighted three-dimensional vessel wall imaging (3D-VWI) technique. In patients with acute non-cardioembolic stroke in middle cerebral artery (MCA) territory, wall thickening of the MCA, which is suggestive of atherosclerotic plaques, was observed in all the patients. In addition, signal intensity of the plaque was significantly increased in the ipsilateral MCA and in the patients with atherothrombolic infarction. In patients with acute vertebrobasilar artery dissection, characteristic findings such as luminal stenosis, aneurysmal dilatation, and intramural hematoma were readily depicted on 3D-VWI when compared with conventional imaging techniques. The 3D-VWI technique can directly visualize intracranial arterial wall lesions in patients with ischemic stroke and dissection, and can be helpful to diagnose these disorders particularly in the acute period.
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