Assessment of functional and anatomical imaging assessed by PET and cardiac MRI in diabetic cardiomyopathy

• Project/Area Number: 23591798
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: MOMOSE Mitsuru 東京女子医科大学, 医学部, 講師 (40312029)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: diabetic cardiomyopathy / N-13 ammonia PET / myocardial flow reserve / cardiac MRI / myocardial blood flow / PET / 心筋血流量 / ＰＥＴ / 糖尿病 / 心筋血流 / アンモニア

Research Abstract

To assess whether diabetic cardiomyopathy (DMCM) is related to myocardial blood flow or flow reserve, 5 patients with low LVEF<45% (DMCM) and 12 patients with DM control (DMc) with normal LVEF underwent N-13 ammonia PET and cardiac MRI(CMR). Stress, rest myocardial blood flow (sMBF, rMBF) and myocardial flow reserve (MFR) by PET and EDV, ESV and EF by CMR were evaluated. There was no significant difference in routine clinical blood data, but significant difference in HbA1c (DMCM<DMc). There was no significant difference in sMBF, rMBF and MFR between the 2 groups. MFR was not correlated with LVEF, but showed negative correlation with age among the all patients. In conclusion, MBF or MFR is not likely to be a factor of pathogenesis for DMCM.